Copper Catalyzed Heteroannelation Reaction between 4‐Thiazolidinones and O‐Acetyl Oximes to Synthesize 2,5‐Diphenyl‐3‐(Pyrimidin‐2‐yl)‐3,4‐Dihydro‐2H‐Pyrrolo‐[2,3‐d]‐Thiazole

Abstract

An intermolecular copper catalyzed heteroannelation reaction using Csp3‐Csp3 radical coupling approach has been accomplished to synthesize 2,5‐diphenyl‐3‐(pyrimidin‐2‐yl)‐3,4‐dihydro‐2H‐pyrrolo[2,3‐d]thiazole. C−C coupling between 4‐thiazolidinones and O‐acetyl oximes under Cu catalyst further cyclizes to get the target molecule thiazolidine‐fused nucleus. This unified method offers access to novel fused heterocycles with pyrimidines bearing 4‐thiazolidinone in moderate to higher yields. The optimization study includes various copper catalysts, oxidants, bases and solvents at different temperatures.