Copper-catalyzed oxidative dehydrogenative dearomatization of indole derivatives: A new strategy to construct spirocyclic indolenines

Aerobic CuBr2-Catalyzed Oxidative Coupling Reaction of Amidines with Exocyclic α,β-Unsaturated Cycloketones for the Synthesis of Spiroimidazolines

“…Furthermore, copper salts and oxygen are naturally abundant, inexpensive, and less toxic in comparison with precious metals and other oxidants. These features confer the strategy of aerobic copper catalysis, one of the most practical methods in a remarkably broad range of organic transformations. , …”

Enantioselective Aminative Dearomatization of Indoles via Electrophilic 1,6-Addition of p-Quinone Diimides (p-QDIs)

“…Catalytic asymmetric dearomatization (CADA) has emerged as a successful strategy to access complex chiral building blocks from simple aromatic substrates . In this context, electrophilic CADA of 2,3-disubstituted indole derivatives provides a promising route for the synthesis of highly substituted chiral quaternary indolenine in a single step . Recent advancements in CADA of 2,3-disubstituted indoles have been achieved through the utilization of appropriate transition metals , and organocatalysts, − which facilitates the C3 electrophilic attack, allowing the generation of chiral indolenines.…”