Copper-catalyzed oxidative direct C3-cyanoarylation of quinoxalin-2(1H)-onesviadenitrogenative ring-opening of 3-aminoindazoles

Abstract

A convenient and efficient copper-catalyzed oxidative arylation of quinoxalin-2(1H)-ones with 3-aminoindazoles is developed for the synthesis of cyanoarylated quinoxalin-2(1H)-ones. Notably, 3-aminoindazoles are employed as efficient arylating agents via the cleavage...