Abstract:The α‐arylation between cyanoacetate and 2‐(2‐bromophenyl)‐1H‐perimidine took place first catalyzed by CuI/L‐proline in the presence of NaHCO3, and then the amino on perimidine chemoselectively attacked the cyano group to undergo a nucleophilic addition, giving a series of 13‐aminoisoquinolino[2,1‐a]perimidine‐12‐carboxylate derivatives in good yields.
“…Huang and coworkers [ 150 ] developed an innovative and chemoselective synthesis from perimidines to produce 13-aminoisoquinolino[2,1- a ]perimidine-12-carboxylate derivatives 33 by α-arylation of cynoacetate catalyzed by combination of CuI, L -proline, and NaHCO 3 in the presence of DMF at 60 °C (Scheme 22 ). Scheme 22 Copper-catalyzed chemoselective synthesis of 13-aminoisoauinolino [2,1-a]perimidine-12-carboxylate …”
Perimidines are versatile scaffolds and a fascinating class of N-heterocycles that have evolved significantly in recent years due to their immense applications in life sciences, medical sciences, and industrial chemistry. Their ability of molecular interaction with different proteins, complex formation with metals, and distinct behavior in various ranges of light makes them more appealing and challenging for future scientists. Various novel technologies have been developed for the selective synthesis of perimidines and their conjugated derivatives. These methods extend to the preparation of different bioactive and industrially applicable molecules. This review aims to present the most recent advancements in perimidine synthesis under varied conditions like MW radiation, ultrasound, and grinding using different catalysts such as ionic liquids, acid, metal, and nanocatalyst and also under green environments like catalyst and solvent-free synthesis. The applications of perimidine derivatives in drug discovery, polymer chemistry, photo sensors, dye industries, and catalytic activity in organic synthesis are discussed in this survey. This article is expected to be a systematic, authoritative, and critical review on the chemistry of perimidines that compiles most of the state-of-art innovation in this area.
“…Huang and coworkers [ 150 ] developed an innovative and chemoselective synthesis from perimidines to produce 13-aminoisoquinolino[2,1- a ]perimidine-12-carboxylate derivatives 33 by α-arylation of cynoacetate catalyzed by combination of CuI, L -proline, and NaHCO 3 in the presence of DMF at 60 °C (Scheme 22 ). Scheme 22 Copper-catalyzed chemoselective synthesis of 13-aminoisoauinolino [2,1-a]perimidine-12-carboxylate …”
Perimidines are versatile scaffolds and a fascinating class of N-heterocycles that have evolved significantly in recent years due to their immense applications in life sciences, medical sciences, and industrial chemistry. Their ability of molecular interaction with different proteins, complex formation with metals, and distinct behavior in various ranges of light makes them more appealing and challenging for future scientists. Various novel technologies have been developed for the selective synthesis of perimidines and their conjugated derivatives. These methods extend to the preparation of different bioactive and industrially applicable molecules. This review aims to present the most recent advancements in perimidine synthesis under varied conditions like MW radiation, ultrasound, and grinding using different catalysts such as ionic liquids, acid, metal, and nanocatalyst and also under green environments like catalyst and solvent-free synthesis. The applications of perimidine derivatives in drug discovery, polymer chemistry, photo sensors, dye industries, and catalytic activity in organic synthesis are discussed in this survey. This article is expected to be a systematic, authoritative, and critical review on the chemistry of perimidines that compiles most of the state-of-art innovation in this area.
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Perimidines are nitrogen-containing heterocyclic scaffolds with a wide range of biological and material proper-ties. Several synthetic transformations on perimidines afford fused heterocycles. This review focuses on every aspect of perimidines including different synthetic procedures, its reactions and applications, and covers literature up to 2020 using more than 170 references.
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