Copper complexes bearing 2-aminobenzothiazole derivatives as potential antioxidant: Synthesis, characterization

Joseph, J.; Janaki, G. Boomadevi

doi:10.1016/j.jphotobiol.2016.06.030

Cited by 21 publications

(9 citation statements)

References 30 publications

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“…Regarding antifungal activity, the compound showed a better anti- Candida effect than fluconazole, used as the reference drug. Previous studies showed that SBs have the ability to modulate oxidative stress [17, 39]. This ability can be exploited in order to use them as antibacterial drugs and/or as potential oxidative stress modulators in medicine.…”

Section: Discussionmentioning

confidence: 99%

A Novel Thiazolyl Schiff Base: Antibacterial and Antifungal Effects and In Vitro Oxidative Stress Modulation on Human Endothelial Cells

Bâldea

Tiperciuc

et al. 2019

Oxidative Medicine and Cellular Longevity

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Schiff bases (SBs) are chemical compounds displaying a significant pharmacological potential. They are able to modulate the activity of many enzymes involved in metabolism and are found among antibacterial, antifungal, anti-inflammatory, antioxidant, and antiproliferative drugs. A new thiazolyl-triazole SB was obtained and characterized by elemental and spectral analysis. The antibacterial and antifungal ability of the SB was evaluated against Gram-positive and Gram-negative bacteria and against three Candida strains. SB showed good antibacterial activity against L. monocytogenes and P. aeruginosa; it was two times more active than ciprofloxacin. Anti-Candida activity was twofold higher compared with that of fluconazole. The effect of the SB on cell viability was evaluated by colorimetric measurement on cell cultures exposed to various SB concentrations. The ability of the SB to modulate oxidative stress was assessed by measuring MDA, TNF-α, SOD1, COX2, and NOS2 levels in vitro, using human endothelial cell cultures exposed to a glucose-enriched medium. SB did not change the morphology of the cells. Experimental findings indicate that the newly synthetized Schiff base has antibacterial activity, especially on the Gram-negative P. aeruginosa, and antifungal activity. SB also showed antioxidant and anti-inflammatory activities.

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Section: Discussionmentioning

confidence: 99%

A Novel Thiazolyl Schiff Base: Antibacterial and Antifungal Effects and In Vitro Oxidative Stress Modulation on Human Endothelial Cells

Bâldea

Tiperciuc

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…Critically, it has been established that insulin resistance and diabetes lead to increases in oxidative stress directly [62–65] or indirectly through increasing inflammation [66, 67]. Incidentally, PRAM administration in T2DM patients reduces the levels of serum markers of oxidative stress [43, 44] and can also form a complex with Cu (II) [68] that can mimics antioxidant enzymes to reduce ROS [69, 70]. Importantly, previous work has shown the ability of PRAM to reduce lipid peroxidation damage and inflammatory markers and stress related responses HO-1 in a mouse model of accelerated aging [29].…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effects of the Amylin Analog, Pramlintide, on Alzheimer’s Disease Are Associated with Oxidative Stress Regulation Mechanisms

Patrick

Corrigan

Grizzanti

et al. 2019

JAD

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Administration of the recombinant analog of the pancreatic amyloid amylin, Pramlintide, has shown therapeutic benefits in aging and Alzheimer’s disease (AD) models, both on cognition and amyloid-beta (Aβ) pathology. However, the neuroprotective mechanisms underlying Pramlintide benefits remain unclear. Given the early and critical role of oxidative stress in AD pathogenesis and the known ROS modulating function of amyloids we sought to determine whether Pramlintide’s neuroprotective effects involve regulation of oxidative stress mechanisms. To address this we treated APP/PS1 transgenic mice with Pramlintide for 3 months, starting at 5.5 months prior to widespread AD pathology onset, and measured cognition (Morris Water Maze), AD pathology, and oxidative stress-related markers and enzymes in vivo. In vitro, we determined the ability of Pramlintide to modulate H2O2-induced oxidative stress levels. Our data show that Pramlintide improved cognitive function, altered amyloid-processing enzymes, reduced plaque burden in the hippocampus, and regulated endogenous antioxidant enzymes (MnSOD and GPx1) and the stress marker HO-1 in a location specific manner. In vitro, Pramlintide treatment in neuronal models reduced H2O2-induced endogenous ROS production and lipid peroxidation in a dose-dependent manner. Together, these results indicate that Pramlintide’s benefits on cognitive function and pathology may involve antioxidant-like properties of this compound.

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“…Side-effect problems of cis-Pt(II) have stimulated chemists to develop alternative anticancer drugs based on different metals. Several studies indicated that copper complexes had showed some promising results [21]. In this study we report the synthesis, spectra characterization of azo -schiff base ligand and its metal complexes with Ni(II), Pd(II), and Pt(IV) ions derived from (E)-5-((E)-(1H-benzo[d]imidazol-2-yl)diazenyl)-N-(4-(dimethylamino)benzylidene) -2-amine -4,6-dimethylpyridin (L2).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral and Biological Studies of Ni(II), Pd(II), and Pt(IV) Complexes with New Heterocyclic ligand Derived from Azo-Schiff Bases Dye

Al-Adilee¹,

Dakheel²

2018

Eurasian J Anal Chem

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New heterocyclic azo-schiff base dye (L2) have been synthesized from a reaction of 4-(dimethylamino)benzaldehyde with (E)-5-((1H-benzo[d]imidazol-2-yl) diazenyl) -2amine-4,6-dimethylpyridin (L1) . A new class of Ni(II), Pd(II), and Pt(IV) complexes of azo-schiff base of the type [Ni(L2)2Cl2], [Pd(L2) Cl2] , and [Pt-2amine-4,6-dimethylpyridin. Both ligand and its metal complexes were characterized by the spectroscopic and analytical methods such as mass spectral, 1 H-NMR, FT-IR, UV-Visb.,X-ray, TGA and SEM, elemental analysis, molar conductance measurements and magnetic susceptibility., spectral studies suggest the mole ratio [M:L] was [1:2] for Ni(II) and Pt(IV) metal ions, but [1:1] for Pd(II) metal ion. The structures of theses complexes were elucidated on the basis of different techniques suggest the structures of the prepared metal complexes octahedral geometry for the Ni(II) and Pt(IV) complexes and square planar geometry for the Pd(II) complex. The antibacterial activity of the ligand and prepared metal complexes was also studied against gram positive Staphylococcus aureus and gram negative bacteria Escherichia coli, the antifungal activity of the azo-schiff base and metal complexes against the fungi Alternaria. It is found that some of the complexes are quite effective against fungi Alternaria. In this study the cytotoxicity of Pd(II)-complex on human (PC3) cancer and normal cells were studied using MTT assay. Pd(II)-complex showed selective cytotoxicity against cancer cell line with IC50 = 450 μg/ml, while it was very safe on normal cells line with IC50 = 14554885 μg /ml, respectively for human cells .The results indicate undoubtedly the possibility of using them as antitumor drugs in the field of medicine and Pharmacy against prostate cancer.

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Copper complexes bearing 2-aminobenzothiazole derivatives as potential antioxidant: Synthesis, characterization

Cited by 21 publications

References 30 publications

A Novel Thiazolyl Schiff Base: Antibacterial and Antifungal Effects and In Vitro Oxidative Stress Modulation on Human Endothelial Cells

A Novel Thiazolyl Schiff Base: Antibacterial and Antifungal Effects and In Vitro Oxidative Stress Modulation on Human Endothelial Cells

Neuroprotective Effects of the Amylin Analog, Pramlintide, on Alzheimer’s Disease Are Associated with Oxidative Stress Regulation Mechanisms

Synthesis, Spectral and Biological Studies of Ni(II), Pd(II), and Pt(IV) Complexes with New Heterocyclic ligand Derived from Azo-Schiff Bases Dye

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