Copper complexes with bioactive ligands

Dudová, Barbora; Hudecová, Daniela; Pokorný, Richard; Mikulášová, Mária; Palicová, Martina; Segľa, Peter; Melnı́k, Milan

doi:10.1007/bf02814425

Cited by 23 publications

(6 citation statements)

References 9 publications

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“…bacteria Staphylococcus aureus CCM 3953, G -bacteria Escherichia coli CCM 3988 and by macrodilution method in L-shape tubes using the yeasts Candida albicans under vigorous shaking [26]. The effect of the tested compounds on the growth of filamentous fungi Rhizopus oryzae CCM F-8284, Alternaria alternate CCM F-128 and Microsporum gypseum CCM F-8342 was observed by macrodilution technique on solidified broth medium during static culturing, and the diameters of growing fungal colonies were measured at selected time intervals [27,28]. The studied compounds were dissolved in dimethylsulphoxide (DMSO).…”

Section: Antimicrobial Assaymentioning

confidence: 99%

Thermal behaviour and antimicrobial assay of some new zinc(II) 2-aminobenzoate complex compounds with bioactive ligands

Krajníková

Rotaru

Györyová

et al. 2014

J Therm Anal Calorim

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New zinc(II) 2-aminobenzoate complexes with general formula Zn(2-NH 2 benz) 2 (L) 2 (where 2-NH 2 benz is 2-aminobenzoate, and L is phenazone, N-methylnicotinamide, nicotinamide and isonicotinamide) were prepared and characterized by elemental analysis and by FTIR spectroscopy. The stability and thermal behaviour of the compounds were studied by thermal analysis techniques (TG/DTG, DTA), and the decomposition reactions were proposed. The decomposition of the studied compounds is always a multistep process, when after the release of the bioactive ligand, 2-aminobenzenecarbaldehyde, 2-aminobenzene and carbon dioxide were evolved. The solid intermediate compounds were confirmed by FTIR spectroscopy, and the volatile products were identified by mass spectrometry. The final solid product of thermal decompositions was zinc oxide, which was confirmed by XRD and FTIR analysis. The nonisothermal kinetic investigation of Zn(2-NH2benz) 2 (mnad) 2 decomposition in air was performed by means of isoconversional methods, for a better understanding of the undergoing processes. The antimicrobial assay was carried out comparatively for the investigated compounds; they have higher biological activity towards Staphylococcus aureus, Escherichia coli and Candida albicans in comparison with zinc(II) 4-bromobenzoates.

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Section: Antimicrobial Assaymentioning

confidence: 99%

Thermal behaviour and antimicrobial assay of some new zinc(II) 2-aminobenzoate complex compounds with bioactive ligands

Krajníková

Rotaru

Györyová

et al. 2014

J Therm Anal Calorim

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“…Antibacterial and anti-yeast activities of the tested compounds were evaluated by a micro-dilution method [11] [12]. The antimicrobial activity was characterized by the IC 50 values (concentration of a derivative which in comparison to the control inhibits the growth of microorganisms to 50%) and MIC values (minimal inhibitory concentration of a derivative which inhibits microbial growth by 100%).…”

Section: Antimicrobial Assaymentioning

confidence: 99%

“…Nicotinic acid is also applied in the skin following topical applications as vasodilator of the peripheral blood capillaries [4] or in the treatment of pellagra [5,6]. Synthesis, spectral and magnetic properties, antimicrobial effects and crystal structures of various CuX 2 Á nH 2 O complexes (where X is nicotinate -nic, isonicotinate -isonic, 2-methylthionicotinate -2-MeSnic; 2,6-dimethoxynicotinate and trans-3-(3-pyridyl)-acrylate, n ¼ 0-4) as well as of their molecular adducts with chelating or N-heterocyclic ligands have been reported [7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectral properties, crystal structures and biological activity of copper(II) pyridinecarboxylates with N -heterocyclic ligands

Segľa¹,

Mikloš²,

Jašková³

et al. 2008

Journal of Coordination Chemistry

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Synthesis and characterization of four new 2,6-dimethoxynicotinate (2,6-(MeO) 2 nic) copper(II) monomeric complexes [Cu(2,6-(MeO) 2 nic) 2 (py) 2 ] (py is pyridine), [Cu{2,6-(MeO) 2 nic} 2 (Etnic) 2 (H 2 O)] (Etnic is ethylnicotinate), [Cu{2,6-(MeO) 2 nic} 2 (Et 2 nia) 2 (H 2 O) 2 ] (Et 2 nia is N,N-diethylnicotinamide) as well as of the polymeric complex [Cu{2,6-(MeO) 2 nic} 2 (ron) 2 ] n (ron is ronicol) are reported. The characterizations were based on elemental analysis, infrared, electronic and EPR spectra. Crystal structures of two of the complexes have been determined. The copper(II) of [Cu{2,6-(MeO) 2 nic} 2 (py) 2 ] has a distorted tetragonal-bipyramidal (4 þ 2) coordination environment. Both 2,6-(MeO) 2 nic anions are asymmetrically chelating. The Cu(II) of [Cu{2,6-(MeO) 2 nic} 2 (Etnic) 2 (H 2 O)] is pentacoordinate in a slightly distorted tetragonal-pyramidal arrangement by two trans nitrogens, each of one Etnic, by two oxygens, each of the carboxyl group of one unidentate 2,6-(MeO) 2 nic and the axial position occupied by water at a longer distance. Antimicrobial effects of the complexes have been tested on various strains of bacteria, yeasts and filamentous fungi. While the 2,6-(MeO) 2 nicH alone did not influence the model bacteria growth, dimeric [Cu{2,6-(MeO) 2 nic} 2 (H 2 O)] 2 and polymeric [Cu{2,6-(MeO) 2 nic} 2 (ron) 2 ] n have pronounced influence on the growth of Staphylococcus aureus, Escherichia coli and Candida parapsilosis.

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“…Different coordination modes of the pyridinecarboxylate (coordinated not only through the carboxylate group, but also through the nitrogen atom of the pyridine ring) lead to formation of mononuclear, dimeric or polynuclear structures. Moreover, biological properties of 2-methylthionicotinatecopper(II) adducts with nicotinamide, isonicotinamide, N-methylnicotinamide or ethylnicotinate have been reported [27,28].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic properties, crystal structure and biological activities of copper(II) 2-methylthionicotinate complexes with furopyridines

Segľa

Miklovič

Mikloš

et al. 2008

Transition Met Chem

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The synthesis and characterization of six new 2-methylthionicotinate (2-MeSnic) copper(II) monomeric complexes [Cu(2-MeSnic) 2 L 2 ] (L is furo[3,2-c]pyridinefpy, 2-methylfuro[3,2-c]pyridine-Mefpy, 2,3-dimethylfuro-[3,2-c]pyridine-Me 2 fpy or benzo[4,5]furo[3,2-c]pyridineBfp), [Cu(2-MeSnic) 2 (fpy) 2 (H 2 O)], as well as [Cu(2-MeSnic) 2 (CF 3 Phfpy) 2 (H 2 O) 2 ] (CF 3 Phfpy is 2-(3-trifluoromethylphenyl)furo[3,2-c]pyridine) are reported. The characterizations were based on elemental analysis, infrared, electronic and EPR spectra. The crystal structure of one of the complexes has been determined. The Cu II atoms of [Cu(2-MeSnic) 2 (fpy) 2 (H 2 O)] are six-coordinated in a highly distorted tetragonal-bipyramidal arrangement by two nitrogen atoms, one from each fpy, in trans-positions, by three oxygen atoms of the carboxyl groups of 2-MeSnic ligands (one monodentate, one asymmetrically bidentate), one axial position being occupied by the oxygen of a water molecule. The antimicrobial effects have been tested on various strains of bacteria, yeasts and filamentous fungi. A comparison of the IC 50 and MIC values has shown a decrease of inhibition activities of tested compounds in the order: [Cu(2-MeSnic) 2 (Bfp) 2 ] [ Bfp [ [Cu(2-MeSnic) 2 (CF 3 Phfpy) 2 (H 2 O) 2 ] [ [Cu-(2-MeSnic) 2 (Me 2 fpy) 2 ] [ CF 3 Phfpy [ [Cu(2-MeSnic) 2 (Mefpy) 2 ] [ Me 2 fpy [ [Cu(2-MeSnic) 2 (fpy) 2 (H 2 O)] [ [Cu(2-MeSnic) 2 (H 2 O)] 2 [ Mefpy [ fpy = 2-MeSnicH = CuSO 4 .

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Copper complexes with bioactive ligands

Cited by 23 publications

References 9 publications

Thermal behaviour and antimicrobial assay of some new zinc(II) 2-aminobenzoate complex compounds with bioactive ligands

Thermal behaviour and antimicrobial assay of some new zinc(II) 2-aminobenzoate complex compounds with bioactive ligands

Synthesis, spectral properties, crystal structures and biological activity of copper(II) pyridinecarboxylates with N -heterocyclic ligands

Synthesis, spectroscopic properties, crystal structure and biological activities of copper(II) 2-methylthionicotinate complexes with furopyridines

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