Copper deficiency

Chhetri, Suresh Kumar; Mills, R. J.; Shaunak, S.; Emsley, Hedley

doi:10.1136/bmj.g3691

Cited by 23 publications

(20 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hematological manifestations almost universally respond to copper supplementation, whereas neurological improvement is often reported as slow, incomplete, or even absent [23], making prompt diagnosis and treatment essential for successful outcomes.…”

Section: Conclusion/learning Pointsmentioning

confidence: 99%

Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathy

Wazir

Ghobrial

2017

Journal of Community Hospital Internal Medicine Perspectives

108

View full text Add to dashboard Cite

Clinical copper deficiency is now more frequently recognized. Hematologically, it can present as anemia (microcytic, normocytic, or macrocytic) and neutropenia. Thrombocytopenia is relatively rare. Neurologically, it can manifest as myelopathy and peripheral neuropathy simulating subacute combined degeneration. Bone marrow findings can mimic myelodysplasia resulting in occasional inappropriate referral for bone marrow transplantation. Other conditions with similar presentations include infections, drug toxicity, autoimmunity, B12 deficiency, folate deficiency, myelodysplastic syndrome, aplastic anemia, and lymphoma with bone marrow involvement. Hematological, but not neurological, manifestations respond promptly to copper replacement, making early diagnosis essential for good outcome. Common risk factors for copper deficiency are foregut surgery, dietary deficiency, enteropathies with malabsorption, and prolonged intravenous nutrition (total parenteral nutrition). We present a unique case of copper deficiency, with no apparent known risk factors.

show abstract

Section: Conclusion/learning Pointsmentioning

confidence: 99%

Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathy

Wazir

Ghobrial

2017

Journal of Community Hospital Internal Medicine Perspectives

108

View full text Add to dashboard Cite

show abstract

“…Indeed, in 1 review, the time for neuorolgic onset following gastric surgery was 5–26 years and 10–46 years for bariatric and nonbariatric patients, respectively . In 2 case reports, men in their 70s with neurologic symptoms secondary to copper deficiency, akin to the patient in this case, had had gastric bypass surgery in their 20s and 30s . Copper deficiency leading to neurologic sequaelae is being recognized more and more in the literature.…”

Section: Discussion and Literature Reviewmentioning

confidence: 90%

Copper Deficiency Myelopathy After Upper Gastrointestinal Surgery

et al. 2017

View full text Add to dashboard Cite

A well-functioning alimentary canal is required for adequate nutrient absorption. Disruption to the upper gastrointestinal tract through surgery can lead to micronutrient malnourishment. Copper deficiency has been noted in up to 10% of those undergoing Roux-en-Y gastric bypass surgery, but sequalae are not frequently reported. The resultant deficiency states can have profound and long-term consequences if not realized early and managed appropriately. Here we present a case of copper deficiency myelopathy, a condition indistinguishable from subacute combined degeneration of the spinal cord, following upper gastrointestinal bypass surgery for gastric ulceration, further complicated by inadequate nutrition.

show abstract

“…Similar to vitamin B12 deficiency, copper deficiency can lead to neurologic symptoms, particularly upper and lower extremity parathesias and ataxia due to dorsal column dysfunction. These symptoms typically are only partially reversible with copper supplementation and the majority of adults who develop copper deficiency related cytopenias already have neurologic symptoms at the time of diagnosis . Many pediatric patients who receive jejunal nutrition have chronic medical conditions that put them at risk for anemia and neurologic symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…Copper deficiency is a known cause of anemia and neutropenia, and when unrecognized can be mistaken for myelodysplastic syndrome. Copper deficiency can also lead to a progressive myeloneuropathy that may be irreversible by the time cytopenias develop …”

Section: Introductionmentioning

confidence: 99%

Refractory cytopenias secondary to copper deficiency in children receiving exclusive jejunal nutrition

Jacobson

Kahwash

Chawla

2017

Pediatric Blood & Cancer

View full text Add to dashboard Cite

Copper deficiency is a known cause of anemia and neutropenia that is easily remedied with copper supplementation. Copper is primarily absorbed in the stomach and proximal duodenum, so patients receiving enteral nutrition via methods that bypass this critical region may be at increased risk for copper deficiency. In pediatrics, postpyloric enteral feeding is increasingly utilized to overcome problems related to aspiration, severe reflux, poor gastric motility, and gastric outlet obstruction. However, little is known about the prevalence of copper deficiency in this population. We describe three pediatric patients receiving exclusive jejunal feeds who developed cytopenias secondary to copper deficiency.

show abstract

Copper deficiency

Cited by 23 publications

References 8 publications

Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathy

Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathy

Copper Deficiency Myelopathy After Upper Gastrointestinal Surgery

Refractory cytopenias secondary to copper deficiency in children receiving exclusive jejunal nutrition

Contact Info

Product

Resources

About