Copper deficiency caused by excessive alcohol consumption

Shibazaki, Shunichi; Uchiyama, Shuhei; Tsuda, Katsuji; Taniuchi, Norihide

doi:10.1136/bcr-2017-220921

Cited by 26 publications

(19 citation statements)

References 20 publications

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“…Copper toxicity seldom occurs but may occur and its consequences may be severe. Intakes of supplements exceeding 3mg copper/day for a protracted period of time may be a cause for concern [36]. Results obtained in this study was observed to be far below and so contradicted that reported by Nyanza et al [34] of range 3.9-169 mg/Kg for geophagic soils in Tanzania.…”

Section: Discussioncontrasting

confidence: 86%

Potential health risk assessment of toxic metals contamination in clay eaten as pica (geophagia) among pregnant women of Ho in the Volta Region of Ghana.

Kortei

Koryo-Dabrah

Akonor

et al. 2020

Preprint

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Introduction: Geophagia although pleasurable and somewhat a necessity among pregnant women, also comes along with its own attendant problems such as exposure to potentially hazardous substances like bacteria, fungi, helminthes and ova, radioactive materials, and toxic elemental minerals in the soil depending on the geographical location.Methodology: This study evaluated the potential health risk involved during the exposure of pregnant women to toxic elemental minerals via the consumption of clay as pica (geophagia). Elemental mineral analysis was carried out using Buck Scientific 210VGP Flame Atomic Absorption Spectrophotometer (Buck Scientific, Inc. East Norwalk, USA). Risk assessment methods were also used to ascertain the various risks factors and the overall risk level.Results: Concentrations of the macro elements investigated were 1.38 ± 1.5, 2.40± 1.5, 7.74± 1.5, 4.01± 1.0, 13.24± 2.2 and 13.76± 2.1 mg/Kg for Fe, Cu, Zn, K, Mg and Na respectively. While that for the micro elements were 1.63± 0.03 µg/Kg, 4.72±0.8, 0.53±0.02 and 1.85±0.3 mg/kg respectively for Arsenic, Manganese, Lead and Nickel. Estimated Daily Intake (EDI), Hazard Quotient (HQ), Target Hazard Quotient (THQ) and Total Target Hazard Quotient (TTHQ) values ranged 0.611- 5.44 (mg/kg Bw/day), 6.26x10-4 – 106.5, 0.067-10.34 and 15 respectively.Conclusion: There is the likelihood of posing adverse health problems when clay samples obtained from Anfoega which is sited in the Volta region of Ghana is consumed due to the fact that the HQ’s of these elemental minerals were >1 which points to high content of Manganese (Mn) and Nickel (Ni). It is also likely to cause adverse health problems in an individual’s life time since THQ for Arsenic, Lead and Nickel were above 1. Ultimately, the cumulative effect of these toxicants were exceedingly great (≤ 15) which implied a high level of unsafety associated with this clay. Per the results from this study, it is not safe for pregnant women to consume clay as pica since these toxic elements may cause detrimental effects on the foetus of the unborn child.

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Section: Discussioncontrasting

confidence: 86%

Potential health risk assessment of toxic metals contamination in clay eaten as pica (geophagia) among pregnant women of Ho in the Volta Region of Ghana.

Kortei

Koryo-Dabrah

Akonor

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Findings derived from these studies were also far from conclusive and sometimes even inconsistent. For example, results from the study by Shibazaki et al[ 48 ] showed that people with excessive alcohol consumption tended to exhibit a significant copper deficiency, which concurs with prior evidence showing copper metabolism perturbations in patients with ALD[ 48 ]. In contrast, another study found that copper levels in patients with ALD were elevated or unchanged as compared with healthy controls[ 49 ].…”

Section: Mineral Malnutrition In Aldsupporting

confidence: 70%

Current understanding of the metabolism of micronutrients in chronic alcoholic liver disease

Meng

2020

WJG

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Alcoholic liver disease (ALD) remains an important health problem worldwide. Perturbation of micronutrients has been broadly reported to be a common characteristic in patients with ALD, given the fact that micronutrients often act as composition or coenzymes of many biochemical enzymes responsible for the inflammatory response, oxidative stress, and cell proliferation. Mapping the metabolic pattern and the function of these micronutrients is a prerequisite before targeted intervention can be delivered in clinical practice. Recent years have registered a significant improvement in our understanding of the role of micronutrients on the pathogenesis and progression of ALD. However, how and to what extent these micronutrients are involved in the pathophysiology of ALD remains largely unknown. In the current study, we provide a review of recent studies that investigated the imbalance of micronutrients in patients with ALD with a focus on zinc, iron, copper, magnesium, selenium, vitamin D and vitamin E, and determine how disturbances in micronutrients relates to the pathophysiology of ALD. Overall, zinc, selenium, vitamin D, and vitamin E uniformly exhibited a deficiency, and iron demonstrated an elevated trend. While for copper, both an elevation and deficiency were observed from existing literature. More importantly, we also highlight several challenges in terms of low sample size, study design discrepancies, sample heterogeneity across studies, and the use of machine learning approaches.

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“…While there are a number of consistent reports on selenium and zinc deficiency and excessive alcohol consumption, reports on copper are scarcer and often inconclusive, or indeed lead to contradictory results [45]. On the one hand, copper deficiency has been reported in a number of studies on alcoholic liver disease (ALD), as well as malnutrition linked to alcoholism [46,47]. However, some studies (Rahelic et al, 2006) have also reported an increase in copper levels of patients suffering from alcoholism, as linked to zinc deficiency [48].…”

Section: Copper Levels In Alcoholismmentioning

confidence: 99%

Serum iron, Magnesium, Copper, and Manganese Levels in Alcoholism: A Systematic Review

et al. 2019

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The aim of this paper was to review recent literature (from 2000 onwards) and summarize the newest findings on fluctuations in the concentration of some essential macro- and microelements in those patients with a history of chronic alcohol abuse. The focus was mainly on four elements which the authors found of particular interest: Iron, magnesium, copper, and manganese. After independently reviewing over 50 articles, the results were consistent with regard to iron and magnesium. On the other hand, data were limited, and in some cases contradictory, as far as copper and manganese were concerned. Iron overload and magnesium deficiency are two common results of an excessive and prolonged consumption of alcohol. An increase in the levels of iron can be seen both in the serum and within the cells, hepatocytes in particular. This is due to a number of factors: Increased ferritin levels, lower hepcidin levels, as well as some fluctuations in the concentration of the TfR receptor for transferrin, among others. Hypomagnesemia is universally observed among those suffering from alcoholism. Again, the causes for this are numerous and include malnutrition, drug abuse, respiratory alkalosis, and gastrointestinal problems, apart from the direct influence of excessive alcohol intake. Unfortunately, studies regarding the levels of both copper and manganese in the case of (alcoholic) liver disease are scarce and often contradictory. Still, the authors have attempted to summarize and give a thorough insight into the literature available, bearing in mind the difficulties involved in the studies. Frequent comorbidities and mutual relationships between the elements in question are just some of the complications in the study of this topic.

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Copper deficiency caused by excessive alcohol consumption

Cited by 26 publications

References 20 publications

Potential health risk assessment of toxic metals contamination in clay eaten as pica (geophagia) among pregnant women of Ho in the Volta Region of Ghana.

Potential health risk assessment of toxic metals contamination in clay eaten as pica (geophagia) among pregnant women of Ho in the Volta Region of Ghana.

Current understanding of the metabolism of micronutrients in chronic alcoholic liver disease

Serum iron, Magnesium, Copper, and Manganese Levels in Alcoholism: A Systematic Review

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