Copper Deficiency in Infants with Active Celiac Disease

Abstract

SummaryCeliac disease was diagnosed in two unrelated infants aged 7 and 7.5 months with severe malnutrition. They showed typical clinical, biological, and histological signs of the disease. Moreover, accompanying copper deficiency was suggested by severe hypocupremia and persistent neutropenia; bone radiographs were also compatible with this diagnosis. Rapid and complete correction of these anomalies could only be obtained after addition of oral copper sulfate to the gluten free diet. Mechanisms possibly involved in the development of copper deficiency in young infants with celiac disease are: (a) chronic malabsorption; (b) high copper needs in rapidly growing infants; and (c) possibly increased biliary and digestive losses. It is therefore suggested that young children with severe celiac disease should be monitored for their copper status.