2023
DOI: 10.1101/2023.12.16.23300061
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Copper-deficiency is associated with impairments in social behavior and oligodendrocyte development via mTOR signaling pathway

Noriyoshi Usui,
Miyuki Doi,
Stefano Berto
et al.

Abstract: Autism spectrum disorder (ASD) is a heterogeneous disorder characterized by impaired social communication and restricted repetitive behaviors, however the biological mechanisms remain unclear. Although trace elements play essential roles in the living body, it is unclear how alterations of trace elements in ASD are involved in pathogenesis. Here we analyzed the plasma metallome and identified the alterations of 11 elements in individuals with ASD. The copper decrease was negatively correlated with ASD symptom … Show more

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