Copper depletion combined with photothermal therapy suppresses breast cancer

Li, Chaonan; Hao, Dengyuan; Wang, Xue; Sun, Tingting; Xie, Zhigang

doi:10.1039/d2qm00445c

Cited by 5 publications

(2 citation statements)

References 40 publications

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“…To achieve enhanced therapeutic efficacy, Li et al combined metal chelation and photothermal therapy (PTT) based on a dye molecule (PY-TBDP) containing copper chelation (the derivative of dipicolylamine, PY) and photothermal agent (the derivative of boron dipyrromethene, TBDP). [69] When copper was bound with PY, the fluorescence intensity of TBDP gradually decreased, thus realizing the real-time tracking of copper binding. Under the irradiation of 685 nm laser, there was no significant change in the photothermal activity of TBDP nanoparticles (NPs), PY-TBDP NPs, and PY-TBDP NPs bound with copper.…”

Section: Copper Depletion Therapy Based On Nanomaterialsmentioning

confidence: 99%

Multifaceted Roles of Copper Ions in Anticancer Nanomedicine

Yang

Song

et al. 2023

Adv Healthcare Materials

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The significantly increased copper level in tumor tissues and serum indicates the close association of copper ions with tumor development, making copper ions attractive targets in the development of novel tumor treatment methods. The advanced nanotechnology developed in the past decades provides great potential for tumor therapy, among which Cu‐based nanotherapeutic systems have received greater attention. Here, the multifaceted roles of copper ions in cancer progression are summarized and the recent advances in the copper‐based nanostructures or nanomedicines for different kinds of tumor therapies including copper depletion therapy, copper‐based cytotoxins, copper‐ion‐based chemodynamic therapy and its combination with other treatments, and copper‐ion‐induced ferroptosis and cuproptosis activation are discussed. Furthermore, the perspectives for the further development of copper‐ion‐based nanomedicines for tumor therapy and clinic translation are presented by the authors.

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Section: Copper Depletion Therapy Based On Nanomaterialsmentioning

confidence: 99%

Multifaceted Roles of Copper Ions in Anticancer Nanomedicine

Yang

Song

et al. 2023

Adv Healthcare Materials

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“…Copper is a cofactor of most metalloenzymes or proteins and wildly participates in multiple metabolic processes. − An imbalance of copper homeostasis can lead to the malignant progression of tumors. − Malignant cells, especially TNBC, have a higher demand for copper because their proliferation, angiogenesis, metastasis, and immune evasion are highly dependent on the signaling pathways related to copper metabolism. ,,− Copper-dependent targets have inspired great interest in leveraging copper accumulation or depletion to disrupt these processes. ,− A previous study has reported a small-molecule inhibitor to block the copper chaperone for attenuating cancer cell proliferation . Intriguingly, removal of intracellular copper ions can intervene in the downstream signaling pathway of the copper chaperone and cause cascaded dysfunction of copper-dependent enzymes, ,− which is a prospective treatment regimen for TNBC.…”

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confidence: 99%

A Paclitaxel Prodrug with Copper Depletion for Combined Therapy toward Triple-Negative Breast Cancer

Hao

Qian

et al. 2023

ACS Nano

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Tuning the content of copper is of great significance for the treatment of cancer and neurodegenerative diseases. Herein, we synthesized a redox-responsive paclitaxel (PTX) prodrug by conjugating PTX with a copper chelator through a disulfide bond. The as-fabricated prodrug (PSPA) showed specific chelation toward copper ions and could assemble with distearoyl phosphoethanolamine-PEG 2000 to form stable nanoparticles (PSPA NPs) in aqueous media. Upon being internalized by tumor cells, PSPA NPs could respond to high levels of redox-active species inside cells and efficiently release PTX. The copper chelator could increase oxidative stress-and abnormal metabolism-induced cell death through intracellular copper depletion. The combination of chemotherapy and copper depletion therapy generated an enhanced therapeutic outcome toward triple-negative breast cancer with an ignorable systemic toxicity. Our work may provide insight into the combination of metabolic regulation and chemotherapy for combating malignant tumors.

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