Copper-doped 3D porous coating developed on Ti-6Al-4V alloys and its in vitro long-term antibacterial ability

Liang, Tao; Wang, Yaping; Zeng, Lilan; Liu, Yuzhi; Qiao, Liping; Zhang, Shufang; Zhao, Rongfang; Li, Guoqiang; Zhang, Rongfa; Xiang, Junhuai; Xiong, Fucheng; Shanaghi, Ali; Pan, Haobo; Zhao, Ying

doi:10.1016/j.apsusc.2019.144717

Cited by 40 publications

(21 citation statements)

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“…As such, no harmful content of Cu was assessed as of 2 wt.pct in a coating [ 46 ]. Moreover, there are several reports of introducing antibacterial properties together with increasing bioactivity and biocompatibility for Cu-incorporated HAp [ 51 ], Cu-doped polymer–ceramic coating [ 52 ], and Cu-implemented anodic coatings [ 53 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanical Behavior of Bi-Layer and Dispersion Coatings Composed of Several Nanostructures on Ti13Nb13Zr Alloy

et al. 2021

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Titanium implants are commonly used because of several advantages, but their surface modification is necessary to enhance bioactivity. Recently, their surface coatings were developed to induce local antibacterial properties. The aim of this research was to investigate and compare mechanical properties of three coatings: multi-wall carbon nanotubes (MWCNTs), bi-layer composed of an inner MWCNTs layer and an outer TiO2 layer, and dispersion coatings comprised of simultaneously deposited MWCNTs and nanoCu, each electrophoretically deposited on the Ti13Nb13Zr alloy. Optical microscopy, scanning electron microscopy, X-ray electron diffraction spectroscopy, and nanoindentation technique were applied to study topography, chemical composition, hardness, plastic and elastic properties. The results demonstrate that the addition of nanocopper or titanium dioxide to MWCNTs coating increases hardness, lowers Young’s modulus, improves plastic and elastic properties, wear resistance under deflection, and plastic deformation resistance. The results can be attributed to different properties, structure and geometry of applied particles, various deposition techniques, and the possible appearance of porous structures. These innovative coatings of simultaneously high strength and elasticity are promising to apply for deposition on long-term titanium implants.

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Section: Introductionmentioning

confidence: 99%

Mechanical Behavior of Bi-Layer and Dispersion Coatings Composed of Several Nanostructures on Ti13Nb13Zr Alloy

et al. 2021

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“…In addition, the implantation of Na through plasma immersion has been found to stimulate the osteogenic differentiation of cells [ 102 ]. Moreover, KOH [ 60 , 70 , 88 ] is used as an alternative base for NaOH given its similar effects on osteogenic differentiation [ 103 ].…”

Section: Synthesis and Characterization Of Peo Biofunctionalized Smentioning

confidence: 99%

“…While all studies that performed XRD analysis identified the TiO 2 phases, not all studies analyzed the other phases formed by the elements incorporated from the electrolyte. Since many PEO electrolytes contain both Ca and P, 19% of the studies observed hydroxyapatite [ 31 , 35 , 50 , 55 , 56 , 57 , 58 , 64 , 65 ] and 28% contain other Ca/P phases including α-TCP [ 35 , 52 , 53 ], β-TCP [ 52 , 53 ], TiP 2 O 7 [ 70 ], CaTiO 3 [ 31 , 55 , 56 , 57 , 58 , 65 ], Ca 2 P 2 O 7 [ 35 , 52 ], and Ca 3 (PO 4 ) 2 [ 31 , 71 ]. In addition, phases with Cu, Cu 2 O, and CuO [ 76 , 78 ], as well as ZnO [ 78 , 79 , 87 ] were observed.…”

Section: Synthesis and Characterization Of Peo Biofunctionalized Smentioning

confidence: 99%

“…Given the relatively low rate of IAI induced by Enterobacteriaceae , it is surprising that 31% of the studies investigated the effects of the implant surfaces on E. coli . While some studies that analyzed both S. aureus and E. coli reported a stronger antibacterial effect against E. coli as compared to S. aureus [ 49 , 51 , 55 , 65 , 83 , 98 ], others reported a similar antibacterial effect for both species [ 35 , 37 , 70 , 74 , 84 , 88 ]. Interestingly, up to 42% of IAI in patients were caused by culture-negative (i.e., undefined) bacteria [ 149 , 150 ] and therefore warrant an antibacterial agent effective against a wide antimicrobial spectrum.…”

Section: Antibacterial Propertiesmentioning

confidence: 99%

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Antibacterial Titanium Implants Biofunctionalized by Plasma Electrolytic Oxidation with Silver, Zinc, and Copper: A Systematic Review

Hengel

Tierolf

Fratila‐Apachitei

et al. 2021

IJMS

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Patients receiving orthopedic implants are at risk of implant-associated infections (IAI). A growing number of antibiotic-resistant bacteria threaten to hamper the treatment of IAI. The focus has, therefore, shifted towards the development of implants with intrinsic antibacterial activity to prevent the occurrence of infection. The use of Ag, Cu, and Zn has gained momentum as these elements display strong antibacterial behavior and target a wide spectrum of bacteria. In order to incorporate these elements into the surface of titanium-based bone implants, plasma electrolytic oxidation (PEO) has been widely investigated as a single-step process that can biofunctionalize these (highly porous) implant surfaces. Here, we present a systematic review of the studies published between 2009 until 2020 on the biomaterial properties, antibacterial behavior, and biocompatibility of titanium implants biofunctionalized by PEO using Ag, Cu, and Zn. We observed that 100% of surfaces bearing Ag (Ag-surfaces), 93% of surfaces bearing Cu (Cu-surfaces), 73% of surfaces bearing Zn (Zn-surfaces), and 100% of surfaces combining Ag, Cu, and Zn resulted in a significant (i.e., >50%) reduction of bacterial load, while 13% of Ag-surfaces, 10% of Cu-surfaces, and none of Zn or combined Ag, Cu, and Zn surfaces reported cytotoxicity against osteoblasts, stem cells, and immune cells. A majority of the studies investigated the antibacterial activity against S. aureus. Important areas for future research include the biofunctionalization of additively manufactured porous implants and surfaces combining Ag, Cu, and Zn. Furthermore, the antibacterial activity of such implants should be determined in assays focused on prevention, rather than the treatment of IAIs. These implants should be tested using appropriate in vivo bone infection models capable of assessing whether titanium implants biofunctionalized by PEO with Ag, Cu, and Zn can contribute to protect patients against IAI.

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“…They have also been used in antimicrobial research fields due to their high penetration power, even inside cells, and because they have excellent ligand-binding properties due to their high surface-area-to-volume ratio [8]. The use of nanoparticles as an antibacterial agent remains the focus of many current studies and considers metal nanoparticles like silver, gold, copper, iron and metal oxide nanoparticles, such as zinc oxide, copper oxide, titanium oxide and iron oxide [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Novel Hydrophobic Nanostructured Antibacterial Coatings for Metallic Surface Protection

et al. 2022

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A simple and cost-efficient method to modify different surfaces in order to improve their bioactivity, corrosion and wear resistance proved to be sol-gel coatings. The silane layers have been shown to be effective in the protection of steel, aluminum or magnesium alloys and copper and copper alloys. Moreover, it has been found that the adding of different inorganic nanoparticles into silica films leads to increasing their performance regarding corrosion protection. In this study, we fabricated, a simple sol-gel method, transparent mono- and bi-layered hydrophobic coatings with simultaneous antibacterial, hydrophobic and anti-corrosive properties for the protection of metallic surfaces against the action of air pollutants or from biological attacks of pathogens. The first layer (the base) of the coating contains silver (Ag) or zinc oxide (ZnO) nanoparticles with an antibacterial effect. The second layer includes zinc oxide nanoparticles with flower-like morphology to increase the hydrophobicity of the coating and to improve corrosion-resistant properties. The second layer of the coating contains a fluorinated silica derivative, 1H,1H,2H,2H-perfluorooctyl triethoxysilane (PFOTES), which contributes to the hydrophobic properties of the final coating by means of its hydrophobic groups. The mono- and bi-layered coatings with micro/nano rough structures have been applied by brushing on various substrates, including metallic surfaces (copper, brass and mild steel) and glass (microscope slides). The as-prepared coatings showed improved hydrophobic properties (water CA >90°) when compared with the untreated substrates while maintaining the transparent aspect. The corrosion resistance tests revealed significantly lower values of the corrosion rates recorded for all the protected metallic surfaces, with the lowest values being measured for the bi-layered coatings containing ZnO particles, both in the first and in the second layers of the coating. Considering the antibacterial activity, the most effective were the AOAg-II and AOZnO-II coatings, which exhibited the highest reduction of microbial growth.

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Copper-doped 3D porous coating developed on Ti-6Al-4V alloys and its in vitro long-term antibacterial ability

Cited by 40 publications

References 41 publications

Mechanical Behavior of Bi-Layer and Dispersion Coatings Composed of Several Nanostructures on Ti13Nb13Zr Alloy

Mechanical Behavior of Bi-Layer and Dispersion Coatings Composed of Several Nanostructures on Ti13Nb13Zr Alloy

Antibacterial Titanium Implants Biofunctionalized by Plasma Electrolytic Oxidation with Silver, Zinc, and Copper: A Systematic Review

Novel Hydrophobic Nanostructured Antibacterial Coatings for Metallic Surface Protection

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