Copper-doped cotton-like malleable electrospun bioactive glass fibers for wound healing applications

Liverani, Liliana; Reiter, Theresa; Zheng, Kai; Neščaková, Zuzana; Boccaccını, Aldo R.

doi:10.1016/j.mlblux.2022.100133

Cited by 4 publications

(6 citation statements)

References 17 publications

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“…More sophisticated versions of BG nanofibers such as those made as hollow mesoporous fibers (∼600 nm in diameter) have also been synthesized using high molecular weight poly(ethylene oxide) (PEO) as the phase separation (and then sacrificial) agent [ 106 ]. Recently, cotton-like Cu ion-doped BG nanofibers have been developed by a similar sol electrospinning technique [ 107 ].…”

Section: Reviewmentioning

confidence: 99%

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Bioactive glass-based fibrous wound dressings

Homaeigohar

Boccaccını

2022

Burns &Amp; Trauma

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Since the discovery of silicate bioactive glass (BG) by Larry Hench in 1969, different classes of BGs have been researched over decades mainly for bone regeneration. More recently, validating the beneficial influence of BGs with tailored compositions on angiogenesis, immunogenicity and bacterial infection, the applicability of BGs has been extended to soft tissue repair and wound healing. Particularly, fibrous wound dressings comprising BG particle reinforced polymer nanofibers and cotton-candy-like BG fibers have been proven to be successful for wound healing applications. Such fibrous dressing materials imitate the physical structure of skin’s extracellular matrix and release biologically active ions e.g. regenerative, pro-angiogenic and antibacterial ions, e.g. borate, copper, zinc, etc., that can provoke cellular activities to regenerate the lost skin tissue and to induce new vessels formation, while keeping an anti-infection environment. In the current review, we discuss different BG fibrous materials meant for wound healing applications and cover the relevant literature in the past decade. The production methods for BG-containing fibers are explained and as fibrous wound dressing materials, their wound healing and bactericidal mechanisms, depending on the ions they release, are discussed. The present gaps in this research area are highlighted and new strategies to address them are suggested.

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Section: Reviewmentioning

confidence: 99%

“…Conversely, Si ions provoke proliferation of endothelial cells and upregulate the expression of VEGF and bFGF by fibroblasts, thereby enhancing angiogenesis [ 124 , 144 ]. In the field of silicate cotton-like fibers, recently, Cu-doped nanofibers were developed [ 96 , 107 ]. Other than silicate BGs, borate BGs, e.g.…”

Section: Reviewmentioning

confidence: 99%

Bioactive glass-based fibrous wound dressings

Homaeigohar

Boccaccını

2022

Burns &Amp; Trauma

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“…There are a variety of surface modification methods for GF, as described in Figure 1 . The most common methods are coating modification [ 26 , 27 , 28 , 29 , 30 ], fluorination modification [ 13 ], chemical grafting modification [ 31 , 32 , 33 ], redox modification [ 22 ], acid–base etching modification [ 34 , 35 , 36 ], plasma treatment [ 37 , 38 ], and doping modification [ 39 , 40 ]. These modification methods can improve the comprehensive properties of GF and provide a way for the functionalization or even multi-functionalization of various GF derivatives.…”

Section: Surface Modification Methodsmentioning

confidence: 99%

“…Liverani prepared electrospun copper-doped GF by a combination of electrospinning and sol–gel techniques. The results showed that copper was successfully incorporated into the GF [ 39 ].…”

Section: Surface Modification Methodsmentioning

confidence: 99%

Recent Progress in Modifications, Properties, and Practical Applications of Glass Fiber

Song

et al. 2023

Molecules

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As a new member of the silica-derivative family, modified glass fiber (MGF) has attracted extensive attention because of its excellent properties and potential applications. Surface modification of glass fiber (GF) greatly changes its performance, resulting in a series of changes to its surface structure, wettability, electrical properties, mechanical properties, and stability. This article summarizes the latest research progress in MGF, including the different modification methods, the various properties, and their advanced applications in different fields. Finally, the challenges and possible solutions were provided for future investigations of MGF.

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“…Recently, an innovative approach of integration of antibacterial nanoparticles into monolithic nanofiber scaffolds has been investigated due to its advantages of cost-effectiveness, quick response, and structural simplicity. Metal (Cu, Au), − metallic oxide (Fe 3 O 4 , glass particles), , or extracted bioparticles such as cellulose nanocrystal particles , incorporated into monolithic fiber scaffolds for controlled drug delivery has aroused great interest. For example, silver nanoparticles were incorporated into cotton fibers, which demonstrated great antibacterial activities. − Silica nanoparticles encapsulating fluorescein and rhodamine B were integrated into poly(lactic- co -glycolic acid) (PLGA) fibrous scaffolds, demonstrating controlled release of drugs. − Results from Xing’s study showed lysophosphatidic acid and zinc oxide nanoparticles were successfully incorporated into nanofibers .…”

Section: Introductionmentioning

confidence: 99%

Incorporation of Gentamicin-Encapsulated Poly(lactic-co-glycolic acid) Nanoparticles into Polyurethane/Poly(ethylene oxide) Nanofiber Scaffolds for Biomedical Applications

Sun,

Heacock,

Chen

et al. 2023

ACS Appl. Nano Mater.

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The development of wound-dressing materials has attracted significant research interests in recent years. With the advancement of nanofabrication, the application of nanoparticles (NPs) in drug delivery systems has become feasible. However, most existing work focuses on incorporation of metal, metal/semimetal oxide, or organic particles into nanofiber scaffolds. There has been a lack of work on the incorporation of drug-encapsulated polymeric particles into nanofiber scaffolds. In this study, gentamicin-encapsulated poly(lactic-co-glycolic acid) (PLGA) NPs were synthesized via a double emulsion solvent evaporation method. Electrospinning was used to incorporate gentamicinencapsulated PLGA NPs into nanofiber scaffolds. Atomic force microscopy (AFM), dynamic light scattering, scanning electron microscopy (SEM), ultraviolet−visible spectroscopy (UV−vis), and an agar diffusion method were utilized to characterize the morphologies, release profiles, and antibacterial activities of various gentamicin-loaded PLGA NP-incorporated nanofiber scaffolds. The results indicated that the PLGA NPs had a spherical morphology with an average diameter of 130 nm. Purification of PLGA NPs was essential to eliminate the residual poly(vinyl alcohol) (PVA) and to prevent particle agglomeration. The purified PLGA NPs were uniformly and individually incorporated into the polyurethane (PU)/ poly(ethenyl oxide) (PEO) or PEO-only nanofiber scaffolds but nearly none into the PU-only fiber scaffolds. PEO served as a continuous phase in the PU/PEO mixture, which significantly improved the compatibility of PLGA NPs and PU, resulting in a well-dispersed distribution of PLGA NPs in the monolithic nanofiber scaffolds. Excellent antibacterial properties against Escherichia coli were found in both PU/PEO and PEO nanofiber scaffolds. This study of incorporating gentamicin-encapsulated PLGA NPs into fiber scaffolds provides insights for achieving successful incorporation of drug-encapsulated polymeric NPs into fiber scaffolds. This offers a promising microfabrication technology for delivery of therapeutic molecules with controlled release for biomedical applications.

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Copper-doped cotton-like malleable electrospun bioactive glass fibers for wound healing applications

Cited by 4 publications

References 17 publications

Bioactive glass-based fibrous wound dressings

Bioactive glass-based fibrous wound dressings

Recent Progress in Modifications, Properties, and Practical Applications of Glass Fiber

Incorporation of Gentamicin-Encapsulated Poly(lactic-co-glycolic acid) Nanoparticles into Polyurethane/Poly(ethylene oxide) Nanofiber Scaffolds for Biomedical Applications

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