Copper-Doped Nano Laponite Coating on Poly(butylene Succinate) Scaffold with Antibacterial Properties and Cytocompatibility for Biomedical Application

Tang, Xiaoming; Dai, Jiangdong; Sun, Hailang; Saha, Nabanita; Sáha, Petr; Tang, Liangchen; Cheng, Qilin; Wang, Deqiang; Wei, Jie

doi:10.1155/2018/5470814

Cited by 20 publications

(20 citation statements)

References 33 publications

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“…The total releases of Si 4+ ions from the scaffolds during 21 days were similar and in the range of 152.82–153.89 ppm. Similarly, Tang et al 20 reported the releases of Si 4+ ions from the scaffolds coated with LAP and copper‐loaded LAP were similar.…”

Section: Resultsmentioning

confidence: 71%

“…To investigate the release of Si 4+ and Co 2+ ions from the scaffolds, samples (0.5 × 0.5 cm 2 ) were soaked in the culture medium in a 96‐well plate, the media was refreshed after 1, 3, 7, 10, 14, and 21 days and the concentrations of Si 4+ and Co 2+ ions released from the PCL@CMC/LAP and PCL@CMC/LAP‐Co scaffolds in the media were obtained by inductively coupled plasma atomic emission spectrometry (ICP‐OES; Varian 715‐ES, USA) 20 …”

Section: Methodsmentioning

confidence: 99%

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Immobilization of cobalt‐loaded laponite/carboxymethyl chitosan on polycaprolactone nanofiber for improving osteogenesis and angiogenesis activities

Arab‐Ahmadi

Irani

Bakhshi

et al. 2021

Polymers for Advanced Techs

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Designing scaffolds with therapeutic potential to stimulate angiogenesis and osteogenesis is considered a promising strategy in the regeneration of large skeletal defects. In this study, the cobalt ions (Co2+) were incorporated in laponite (LAP) nanodiscs (0.65, 1.3, and 2.6 g/L) and, in combination with carboxymethyl chitosan (CMC), were immobilized on the electrospun polycaprolactone (PCL) nanofiber to fabricate scaffolds for simultaneous enhancing osteogenesis and angiogenesis inductions to human bone marrow mesenchymal stem cells. The Fourier transform infrared, energy dispersive X‐ray, and inductively coupled plasma atomic emission spectrometries confirmed the Co2+‐loading on the LAP nanodiscs and the chemical immobilization on the surface of PCL nanofibers. The result of MTT assay, scanning electron microscopy, and fluorescence staining displayed that Co2+‐loaded scaffolds were biocompatible. Furthermore, the incorporation of Co2+ ions into LAP nanodiscs had significant effects on the calcium deposition and expression of osteogenic markers, alkaline phosphatase and osteonectin, as well as, the expression of angiogenic markers, hypoxia‐inducible factor‐1α and vascular endothelial growth factor of the cells seeded on the scaffolds (p ≤ 0.05). These results suggested that the combination of Co2+ ions with CMC/LAP could result in a synergetic effect on the osteogenesis and angiogenesis stimulations.

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Section: Resultsmentioning

confidence: 71%

Section: Methodsmentioning

confidence: 99%

Immobilization of cobalt‐loaded laponite/carboxymethyl chitosan on polycaprolactone nanofiber for improving osteogenesis and angiogenesis activities

Arab‐Ahmadi

Irani

Bakhshi

et al. 2021

Polymers for Advanced Techs

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“…In the case of an application in the medical field, biodegradable polyesters are usually processed in the shape of fibers to find application as scaffolds. Tang et al [ 300 ] coated PBS scaffolds, obtained using the salt leaching method, with copper-doped nano laponite (cnLAP). This material was to be applied in bone tissue engineering; therefore, the authors used nLAP to promote the osteogenic differentiation of human mesenchymal stem cells.…”

Section: Polyestersmentioning

confidence: 99%

“… Photographs of E. coli ( a – d ) and S. aureus ( e – h ) colonies’ growth after incubation for 24 h with PBS ( a , e ), nano laponite (nLAP)-coated PBS (nLBC) ( b , f ), and Cu–nLAP-coated PBS ( c , g ) scaffolds with vancomycin as a positive control ( d , h ). Reproduced from [ 300 ]. …”

Section: Figurementioning

confidence: 99%

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Bio-Based Polymers with Antimicrobial Properties towards Sustainable Development

et al. 2019

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This article concisely reviews the most recent contributions to the development of sustainable bio-based polymers with antimicrobial properties. This is because some of the main problems that humanity faces, nowadays and in the future, are climate change and bacterial multi-resistance. Therefore, scientists are trying to provide solutions to these problems. In an attempt to organize these antimicrobial sustainable materials, we have classified them into the main families; i.e., polysaccharides, proteins/polypeptides, polyesters, and polyurethanes. The review then summarizes the most recent antimicrobial aspects of these sustainable materials with antimicrobial performance considering their main potential applications in the biomedical field and in the food industry. Furthermore, their use in other fields, such as water purification and coating technology, is also described. Finally, some concluding remarks will point out the promise of this theme.

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Rub‐Resistant Antibacterial Surface Conversion Layer on Stainless Steel

Huang

Barber

et al. 2022

Adv Materials Inter

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Coatings consisting of Cu, especially those grown on frequently touched surfaces, are important tools to reduce fomite infections and improve public health. [2] In many hospitals and throughout public transportation systems, stainless steel is one of the most common materials due to its resistance to corrosion, appropriate mechanical properties, and processability. However, stainless steel does not have antimicrobial properties. An ideal disinfecting coating on stainless steels should be durable, safe, and easy to grow. These criteria, however, are challenging to be met simultaneously. For example, a high temperature and/or a high level of vacuum are often required to grow metallic Cu or its alloy on stainless steels, such as plasma spray, wire arc spray, and chemical vapor deposition. [3] Paintings of metallic Cu and Cu oxides particles composited with polymers may suffer from poor adhesion on the substrate, especially when considering the curved shape and fine finish of stainless steel used in those scenarios. Cu ions have also been investigated in coating techniques, such as those using zeolite, [4] laponite, [5] and polyanion [6] as the anchoring agents. Pre-loaded Cu ions can be released into the local aqueous environment of microorganisms to cause inactivation. However, these methods are currently limited to specific types of substrates and are not applicable to stainless steel.The challenge of growing an adherent coating on stainless steel is attributed to its chemical inertness. One way to overcome this is through surface reactions based on a strong oxidizing agent, such as KMnO 4 . This has been utilized for in situ synthesis of electrocatalyst, as reported by previous studies. [7] The reaction between KMnO 4 based precursor solution and stainless steel is spontaneous and self-limiting, leaving a thin and conformal oxyhydroxide surface layer. By adding Cu salts into the precursor solution, we developed a simple method to obtain a Cu-containing coating. It was found that Cu ions can leach from the coating, which may have caused the improved antibacterial activity compared to bare substrates. This solution-processing method can be applied to retrofit already-installed stainless steel parts, such as doorknobs and elevator buttons, with a conformal yet strongly adhering nanocoating for improved antibacterial properties.Stainless steels are widely used in hospitals and public transportation vehicles as one of the most common touch surfaces. Retrofitting stainless steel surfaces with an antimicrobial layer can bring potential public health benefits by reducing the ability of inanimate objects, or fomites, to transmit infections. Here, a facile surface conversion reaction between stainless steel and a solution of KMnO 4 and CuSO 4 is reported, which leads to a conformal and robust oxyhydroxide layer. Microscopy observations show that the layer is amorphous, continuous, and pinhole-free with a thickness of only 10-15 nm. The coating adheres strongly to stainless steel and can resist rubbing in simulated fricti...

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Copper-Doped Nano Laponite Coating on Poly(butylene Succinate) Scaffold with Antibacterial Properties and Cytocompatibility for Biomedical Application

Cited by 20 publications

References 33 publications

Immobilization of cobalt‐loaded laponite/carboxymethyl chitosan on polycaprolactone nanofiber for improving osteogenesis and angiogenesis activities

Immobilization of cobalt‐loaded laponite/carboxymethyl chitosan on polycaprolactone nanofiber for improving osteogenesis and angiogenesis activities

Bio-Based Polymers with Antimicrobial Properties towards Sustainable Development

Rub‐Resistant Antibacterial Surface Conversion Layer on Stainless Steel

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