Copper: Effects of Deficiency and Overload

Scheiber, Ivo F.; Dringen, Ralf; Mercer, Julian F. B.

doi:10.1007/978-94-007-7500-8_11

Cited by 242 publications

(180 citation statements)

References 201 publications

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“…Among the drugs used in this patient, none of them could cause a drop in platelets count. Folate, vitamin B12 and copper deficiencies, can cause a mild pancytopenia, but isolated thrombocytopenia has also been reported after bariatric surgery especially gastric bypass (13). In this patient, blood levels of vitamins and minerals checked, and was normal.…”

Section: Discussionmentioning

confidence: 70%

Idiopathic Thrombocytopenia After Omega Gastric Bypass Surgery: A Case Report

Sayadishahraki

Dehghan

Mahmoudieh

et al. 2017

J Minim Invasive Surg Sci

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Introduction: After cessation of smoking, the best way to prevent health-threatening conditions is to treatment of obesity. Also, obesity treatment, cause alleviation or cure of other diseases. Bariatric surgery in selected obese patients is the best option for preventing health-threatening conditions. Despite the health benefits, this method of treatment -just like other surgical proceduresmay be associated with various side effects. Case Presentation: A 55-year-old female with BMI of 46.5 underwent laparoscopic Omega Gastric bypass surgery. She was admitted due to dyspnea and pulmonary embolism 14 days later. In conducted surveys, platelet count was less than 25,000. In multiple assessments, no cause found for the thrombocytopenia. Corticosteroids prescribed for her with the diagnosis of ITP; which fully responded to treatment. Conclusions: Thrombocytopenia is a rare complication of gastric bypass surgery. Managements include rule out of other causes of thrombocytopenia and medical treatment.

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Section: Discussionmentioning

confidence: 70%

Idiopathic Thrombocytopenia After Omega Gastric Bypass Surgery: A Case Report

Sayadishahraki

Dehghan

Mahmoudieh

et al. 2017

J Minim Invasive Surg Sci

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“…Several neurological disorders, including Alzheimer's disease, Parkinson's disease, Wilson's disease and Menkes disease have been linked to an imbalance in the copper metabolism of the brain [3,11,114,123,124], suggesting that disturbances of astrocytic copper handling may be involved in the pathogenesis of such disorders. If this is the case, astrocytes would be an important target for therapeutic approaches to treat disorders connected with disturbances in brain copper metabolism.…”

Section: Discussionmentioning

confidence: 99%

Handling of Copper and Copper Oxide Nanoparticles by Astrocytes

Bulcke

Dringen

2015

Neurochem Res

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Copper is an essential trace element for many important cellular functions. However, excess of copper can impair cellular functions by copper-induced oxidative stress. In brain, astrocytes are considered to play a prominent role in the copper homeostasis. In this short review we summarise the current knowledge on the molecular mechanisms which are involved in the handling of copper by astrocytes. Cultured astrocytes efficiently take up copper ions predominantly by the copper transporter Ctr1 and the divalent metal transporter DMT1. In addition, copper oxide nanoparticles are rapidly accumulated by astrocytes via endocytosis. Cultured astrocytes tolerate moderate increases in intracellular copper contents very well. However, if a given threshold of cellular copper content is exceeded after exposure to copper, accelerated production of reactive oxygen species and compromised cell viability are observed. Upon exposure to sub-toxic concentrations of copper ions or copper oxide nanoparticles, astrocytes increase their copper storage capacity by upregulating the cellular contents of glutathione and metallothioneins. In addition, cultured astrocytes have the capacity to export copper ions which is likely to involve the copper ATPase 7A. The ability of astrocytes to efficiently accumulate, store and export copper ions suggests that astrocytes have a key role in the distribution of copper in brain. Impairment of this astrocytic function may be involved in diseases which are connected with disturbances in brain copper metabolism.

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“…The human body contains 80-200 mg of copper, mainly in the liver, which regulates its distribution, processing, and excretion. Among the symptoms of copper deficiency are mentioned: ischaemia, neutropaenia, cardiac arrhythmia, degenerative changes in the nervous system, and pseudo-scurvy [38][39][40]. Among the circumstances leading to the accumulation of an excess of copper is impairment of bile flow [41].…”

Section: Introductionmentioning

confidence: 99%