Copper exposure for 30 days at a daily dose twice the recommended increases blood pressure and cardiac contractility

Toscano, Cindy Medici; Filetti, Filipe Martinuzo; Pereira, Camila Almenara Cruz; Fioresi, Mirian; Vassallo, Dalton Valentim

doi:10.1016/j.lfs.2022.120579

Cited by 7 publications

(3 citation statements)

References 37 publications

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“…1 e at certain level of copper 15 mg/d on the 95% CI for the risk of PE is increased. Through reactive oxygen-mediated reactions, excess copper intake can cause DNA damage, lipid peroxidation and protein modification, thereby affecting blood pressure levels 40 . In addition, excess copper causes an increase in the amount of mature collagen and increases resistance to blood vessels 41 .…”

Section: Discussionmentioning

confidence: 99%

The association between dietary mineral intake and the risk of preeclampsia in Chinese pregnant women: a matched case–control study

Liu,

Wang,

et al. 2023

Sci Rep

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Previous studies on the relationship between dietary minerals and preeclampsia (PE) have given inconsistent results. The aim of this study was to further clarify the relationship between dietary minerals intake and PE in Chinese pregnant women. In this study, 440 pairs of hospital–based preeclamptic and healthy women were matched 1:1. Dietary intake was obtained through a 78–item semi–quantitative food frequency questionnaire. Multivariate conditional logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines were plotted to evaluate the dose–response relationship between dietary minerals intake and PE. This study found significant inverse associations for dietary intake of calcium, magnesium, phosphorus, iron, copper, manganese and zinc and the risk of PE in both univariate and multivariate models (all P- trend < 0.05). After adjusting for possible confounders, compared with the lowest quartile, the odds ratio of the highest quartile was 0.74 (95% CI 0.56–0.98) for calcium, 0.63 (95% CI 0.42–0.93) for magnesium, 0.45 (95% CI 0.31–0.65) for phosphorus, 0.44 (95% CI 0.30–0.65) for iron, 0.72 (95% CI 0.53–0.97) for copper, 0.66 (95% CI 0.48–0.91) for manganese and 0.38 (95% CI 0.25–0.57) for zinc. In addition, a reverse J–shaped relationship between dietary minerals intake and PE risk was observed (P–overall association < 0.05). In Chinese pregnant women, a higher intake of dietary minerals, including calcium, magnesium, phosphorus, copper, iron, manganese, and zinc was associated with a lower odds of PE.

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Section: Discussionmentioning

confidence: 99%

The association between dietary mineral intake and the risk of preeclampsia in Chinese pregnant women: a matched case–control study

Liu,

Wang,

et al. 2023

Sci Rep

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“…Copper overload can increase cellular oxidative stress 19 , activate apoptotic pathways 17 – 19 , disrupt mitochondrial respiratory chain transmission 19 , and trigger cellular cuproptosis 20 . Chronic copper overload has been reported to inhibit myocardial contractility by reducing calcium uptake in the sarcoplasmic reticulum 56 . Although there is some evidence of a correlation between copper metabolism and MI/RI 7 , 57 , 58 , the present study verified the occurrence of myocardial cuproptosis in MI/RI.…”

Section: Discussionmentioning

confidence: 99%

Sleep fragmentation exacerbates myocardial ischemia‒reperfusion injury by promoting copper overload in cardiomyocytes

Chen,

Guo,

Wang

et al. 2024

Nat Commun

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Sleep disorders increase the risk and mortality of heart disease, but the brain-heart interaction has not yet been fully elucidated. Cuproptosis is a copper-dependent type of cell death activated by the excessive accumulation of intracellular copper. Here, we showed that 16 weeks of sleep fragmentation (SF) resulted in elevated copper levels in the male mouse heart and exacerbated myocardial ischemia–reperfusion injury with increased myocardial cuproptosis and apoptosis. Mechanistically, we found that SF promotes sympathetic overactivity, increases the germination of myocardial sympathetic nerve terminals, and increases the level of norepinephrine in cardiac tissue, thereby inhibits VPS35 expression and leads to impaired ATP7A related copper transport and copper overload in cardiomyocytes. Copper overload further leads to exacerbated cuproptosis and apoptosis, and these effects can be rescued by excision of the sympathetic nerve or administration of copper chelating agent. Our study elucidates one of the molecular mechanisms by which sleep disorders aggravate myocardial injury and suggests possible targets for intervention.

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“…Cu is an essential trace element necessary for various metabolic functions in the human body [ 11 ]. There is an extensive literature documenting the potential hazard of impaired Cu homeostasis, which is implicated in various cardiovascular, gastrointestinal, and neurological diseases and metabolic disorders [ 9 , 31 , 32 ]. Previous epidemiological studies revealed a link between Cu exposure and kidney impairment.…”

Section: Discussionmentioning

confidence: 99%

Sex-Based Differences in the Association between Serum Copper and Kidney Function: Evidence from NHANES 2011–2016

Nan

Bai

2022

IJERPH

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Epidemiological evidence on the relationship between copper (Cu) and kidney function is rare, and few studies examine the sex differences in this association. We aimed to explore the overall and sex-based relationship between exposure to Cu and biomarkers of kidney function among 4331 participants of the 2011–2016 National Health and Nutrition Examination Survey. Multiple linear regression models were fitted to examine the overall and sex-specific associations between serum Cu and the kidney function indicator-estimated glomerular filtration rate (eGFR) and urinary albumin–creatinine ratio (UACR). Restricted cubic spline models (RCS) stratified by sex were performed to explore the sex-based dose–response associations. Serum Cu in the highest quartile was associated with higher levels of UACR (β = 0.203, 95% CI: 0.100 to 0.306) among overall participants. In males, there was an association of the highest Cu quartile with decreased eGFR (β = −0.023, 95% CI: −0.042 to −0.003) and increased UACR (β = 0.349, 95% CI: 0.171 to 0.527); serum Cu levels also demonstrated a negative nonlinear dose–response association with eGFR and a positive linear dose–response association with UACR in males, whereas females showed a marginally significant nonlinear positive association of eGFR with serum Cu levels. In conclusion, there were sex-specific and dose–response relationships between serum Cu and kidney function indicators. Further prospective and mechanistic studies are warranted.

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Copper exposure for 30 days at a daily dose twice the recommended increases blood pressure and cardiac contractility

Cited by 7 publications

References 37 publications

The association between dietary mineral intake and the risk of preeclampsia in Chinese pregnant women: a matched case–control study

The association between dietary mineral intake and the risk of preeclampsia in Chinese pregnant women: a matched case–control study

Sleep fragmentation exacerbates myocardial ischemia‒reperfusion injury by promoting copper overload in cardiomyocytes

Sex-Based Differences in the Association between Serum Copper and Kidney Function: Evidence from NHANES 2011–2016

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