Copper for the Prevention of Outbreaks of Health Care–Associated Infections in a Long-term Care Facility for Older Adults

Vallet, Lydie; Muggeo, Anaëlle; Champs, Christophe de; Lefebvre, A.; Jolly, Damien; Kanagaratnam, Lukshe

doi:10.1016/j.jamda.2019.02.003

Cited by 32 publications

(42 citation statements)

References 24 publications

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“…We screened 638 titles and abstracts and assessed 16 full-text articles for inclusion. After excluding 6 articles, we included 10 articles pertaining to 7 studies [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] . We also identified 5 relevant clinical trial registries (2 for studies already identified and included and 3 registries for studies that have not been published).…”

Section: Resultsmentioning

confidence: 99%

“…We included 7 controlled studies, which enrolled a total of 12,362 participants 14 , 15 , 17 , 18 , [20] , [21] , [22] . Included studies were conducted in the last decade in the USA (n=3 studies 15 , 18 , 20 ), Chile (n=2 studies 17 , 21 ), France (n=1 study 22 ), and Israel (n=1 study 14 ).…”

Section: Resultsmentioning

confidence: 99%

“…HAIs were determined by standard definitions used by the National Surveillance System of the Ministry of Health of Chile (i.e. infections on and after third admission day) Zerbib 2020 (France) 22 Controlled trial, 16 months 556 nursing home residents (85.4 yrs) Copper-treated surfaces 438 door handles, 322 m of handrails, and 10 grab-bars in copper alloy (containing 90% copper) Regular nursing home setting Rates of infection during outbreak (5 cases in 4 days) Marcus 2017 (Israel) 14 Double-blind, controlled cross-over, 7 months (2 x 3 months, separated by a 1-month washout period) 112 ventilator-dependent patients in a long-term care hospital (69.8 vs 71.3 yrs) Copper-treated textiles Copper oxide–impregnated linen and hospital patients’ clothes and towels. Regular ICU Antibiotic treatment initiation events (ATIEs), fever days, days of antibiotic treatment, and antibiotic defined daily dose (DDD) per 1,000 hospitalization days (HDs).…”

Section: Introductionmentioning

confidence: 99%

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Does copper treatment of commonly touched surfaces reduce healthcare-acquired infections? A systematic review and meta-analysis

Albarqouni

Byambasuren

Clark

et al. 2020

Journal of Hospital Infection

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Background Healthcare acquired infections (HAIs) cause substantial morbidity and mortality. Copper appears to have strong antimicrobial properties under laboratory conditions. Aim We conducted a systematic review to examine the potential effect of copper treating of commonly touched surfaces in healthcare facilities. Methods We included controlled trials comparing the effect of copper-treated surfaces (furniture or bed linens) in hospital rooms versus standard rooms on hospital acquired infections (HAIs). Two reviewers independently screened retrieved articles, extracted data, and assessed the risk of bias of included studies. The primary outcome was the occurrence of healthcare acquired infections. Findings We screened 638 records; 7 studies comprising 12362 patients were included. From risk of bias assessment, all included studies were judged to be at high risk in ≥2 of the 7 domains of bias. All 7 included studies reported the effect of various copper-treated surfaces on HAIs. Overall, we found low quality evidence of a potential clinical importance that copper-treated hard surfaces and/or bed linens and clothes reduced healthcare acquired infections by 27% (RR 0.73; 95% CI 0.57 to 0.94; I 2 = 44%, p-value = 0.01). Conclusion Given the clinical and economic costs of healthcare acquired infections, the potentially protective effect of copper-treated surfaces appears important. However, the current evidence is insufficient to make a strong positive recommendation. However, it would appear worthwhile and urgent to conduct larger scale publicly funded clinical trials of the impact of copper coating.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Does copper treatment of commonly touched surfaces reduce healthcare-acquired infections? A systematic review and meta-analysis

Albarqouni

Byambasuren

Clark

et al. 2020

Journal of Hospital Infection

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“…Similarly, Colin et al [ 11 ] have reported reduced bacterial contamination of copper alloy door handles and handrails fitted in five French long-term care facilities as compared to controls. In a prospective pilot study, Zerbib et al [ 10 ] reported a reduced incidence of hand-transmitted HAI in nursing homes with copper surfaces as compared to controls. To the best of our knowledge, to date, only one meta-analysis has assessed the role of copper in reducing HAI.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of copper-impregnated hospital linen in reducing healthcare-associated infections: A systematic review and meta-analysis

et al. 2020

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Background Healthcare-associated infections (HAI) are a significant burden on the healthcare system. Recent research has suggested the role of copper in reducing HAI. The purpose of this study was to systematically search literature and pool data from studies evaluating the efficacy of copper-impregnated hospital linen in reducing HAI. Methods We carried out a systematic electronic search of PubMed, ScienceDirect, BioMed Central, Springer, Embase, and Google Scholar databases for controlled studies evaluating the efficacy of copper-impregnated linen in reducing the incidence of HAI. The last search was carried out on 15 th February 2020. Results Six studies were included. There was no restriction on the type of organism causing HAI in three studies while three trials reported HAI from Clostridioides difficile and multi-drug resistant organisms (MDRO). A meta-analysis of six studies indicated the use of copper-impregnated linen did not reduce the risk of HAI [Incidence rate ratio (IRR):0.66, 95% CI:0.28–1.58, p = 0.36, I 2 = 100%)]. On subgroup analysis, while pooled data from three studies HAI indicated a statistical significant reduction in all-HAI with copper-impregnated linen (IRR:0.76, 95% CI:0.75–0.77, p<0.00001, I 2 = 0%), no such difference was seen when HAI was defined as infection by Clostridioides difficile and MDROs only (IRR:0.57, 95% CI:0.12–2.75, p = 0.48, I 2 = 99%). Meta-regression analysis for study duration and number of days of hospitalization did not demonstrate any influence on the overall effect size. On sensitivity analysis, there was no change in the significance of results after the sequential exclusion of every study. Conclusion Current evidence on the use of copper-impregnated linen to reduce HAI is conflicting. Our results indicate that copper-impregnated linen may reduce HAI, but there is still no evidence of such an effect regarding infections caused by MDRO or Clostridioides difficile . The overall quality of evidence is not high. Homogenous high-quality studies are required to strengthen the evidence on this subject.

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“…6,47 To what extent can new models of building design, such as the small freestanding units in the Green House Model, 56,57 and the use of nondrug methods of infection control, such as copper surfaces and ultraviolet light, 58 reduce the spread of pathogens from resident to resident? In an article in this issue of JAMDA, Zerbib et al 59 report that introduction of copper surfaces in a nursing home markedly lowered the risk of handtransmitted healthcare-associated infections.…”

Section: Infection Prevention and Controlmentioning

confidence: 99%

Progress and Challenges in the Management of Nursing Home Infections

Sloane

Zimmerman

Nace

2020

Journal of the American Medical Directors Association

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Copper for the Prevention of Outbreaks of Health Care–Associated Infections in a Long-term Care Facility for Older Adults

Cited by 32 publications

References 24 publications

Does copper treatment of commonly touched surfaces reduce healthcare-acquired infections? A systematic review and meta-analysis

Does copper treatment of commonly touched surfaces reduce healthcare-acquired infections? A systematic review and meta-analysis

Efficacy of copper-impregnated hospital linen in reducing healthcare-associated infections: A systematic review and meta-analysis

Progress and Challenges in the Management of Nursing Home Infections

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