2023
DOI: 10.1111/imr.13276
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Copper homeostasis and cuproptosis in cancer immunity and therapy

Wei‐Qing Liu,
Wan‐Rong Lin,
Li Yan
et al.

Abstract: SummaryCopper is an essential nutrient for maintaining enzyme activity and transcription factor function. Excess copper results in the aggregation of lipoylated dihydrolipoamide S‐acetyltransferase (DLAT), which correlates to the mitochondrial tricarboxylic acid (TCA) cycle, resulting in proteotoxic stress and eliciting a novel cell death modality: cuproptosis. Cuproptosis exerts an indispensable role in cancer progression, which is considered a promising strategy for cancer therapy. Cancer immunotherapy has g… Show more

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Cited by 29 publications
(7 citation statements)
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“…Cuproptosis has been implicated in various pathological conditions, including neurodegenerative diseases, liver diseases, and cancer [ 19 ]. Dysregulated copper metabolism and cuproptosis are evident in neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases, where the accumulation of copper in specific brain regions contributes to neuronal cell death [ 20 , 21 ]. In the context of cancer, dysregulated copper transporters and copper chelation have shown promise in inducing cuproptosis as a potential therapeutic strategy [ 22 25 ].…”
Section: Discussionmentioning
confidence: 99%
“…Cuproptosis has been implicated in various pathological conditions, including neurodegenerative diseases, liver diseases, and cancer [ 19 ]. Dysregulated copper metabolism and cuproptosis are evident in neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases, where the accumulation of copper in specific brain regions contributes to neuronal cell death [ 20 , 21 ]. In the context of cancer, dysregulated copper transporters and copper chelation have shown promise in inducing cuproptosis as a potential therapeutic strategy [ 22 25 ].…”
Section: Discussionmentioning
confidence: 99%
“…When comparing ferroptosis and cuproptosis, it is clear that mitochondria play a critical role in both types of cell death. Dihydrolipamide S-acetyltransferase (DLAT) ( Liu et al, 2024 ) is central to this process. Copper directly binds to DLAT, promoting the formation of disulfide bonds in fatty acylated DLAT, which triggers cell death.…”
Section: Fundamental Aspects Of Cuproptosismentioning
confidence: 99%
“…Several copper chelators have been used to reduce copper bioavailability, including D-penicillamine, tetrathiomolybdate (TM), and tetraethylenepentamine (TEPA) ( Liu et al, 2023 ). Inhibitors of oxidative phosphorylation suppress cuproptosis by inhibiting protein stress response.…”
Section: Cuproptosis and Cancer Treatmentmentioning
confidence: 99%