“…In addition, arylation and phosphonylation, two common functionalization reactions for the structural modifications of drug candidates, have attracted great interest in organic synthesis, synthetic methodologies, and pharmaceutical chemistry. With our continuous interests in isocyanide chemistry , and the construction of heterocycles, herein, we describe an unprecedented Mn 3+ -mediated cascade radical arylation/phosphonylation and cyclization reaction of isocyanides with aryl boronic acids/diarylphosphine oxides to afford multifunctional dibenzodiazepines (Figure , eq 2).…”