Copper(II) complexes with substituted thiosemicarbazones of thiophene-2-carboxaldehyde: synthesis, characterization and antiamoebic activity against E. histolytica

Sharma, Sangita; Athar, Fareeda; Maurya, Mannar R.; Azam, Amir

doi:10.1016/j.ejmech.2005.05.013

Cited by 87 publications

(39 citation statements)

References 25 publications

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“…Thiosemicarbazones are of considerable interest because of their chemistry and potentially beneficial biological activity, such as antibacterial, antifungal, antiviral, antiamoebic, antimalarial and antitumor activity (Klayman et al, 1979;Scovill et al, 1984;Klayman et al, 1984;Liberta et al, 1992;West et at., 1993;Liu et al, 1995;Sharma et al, 2005;Rebolleo et al, 2005). The biological activities of thiosemicarbazones are considered to be due to their ability to form chelates with metals.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and biological activity of acetylacetone thiosemicarbazone and their metallic complexes

Kumar¹,

Kumar

2013

Int Curr Pharm J

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In present work, Ligand acetylacetone thiosemicarbazone and their 11 complexes of the type ML2X2, ML2X, where M = Cu(II), Cd(II), Co(II), Zn(II), Hg(II); L = acetylacetone thiosemicarbazone; X = Cl, NO3 or CH3COO; X = SO4 have been synthesized and characterized with the help of molar conductance, magnetic susceptibility measurements, infra-red and ultra-violet spectroscopy. The spectral data revealed that the thiosemicarbazone act as bidentate ligand, making use of thionic sulphur and the azomethine nitrogen atom for co-ordination to the central metal atom. All the compounds have been screened for their antibacterial activity against Gram positive bacteria Staphylococcus aureus, Staphylococcus epidermidis and Gram negative bacteria Escherichia coli and Pseudomonas aeruginosa. Some of complexes exhibited appreciable activity.DOI: http://dx.doi.org/10.3329/icpj.v2i4.14057 International Current Pharmaceutical Journal, March 2013, 2(4): 88-91

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Section: Introductionmentioning

confidence: 99%

Synthesis and biological activity of acetylacetone thiosemicarbazone and their metallic complexes

Kumar¹,

Kumar

2013

Int Curr Pharm J

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“…Thiophene and its derivatives are the significant class of heterocyclic compounds possessing broad biological activities, such as antiinflammatory 14 , analgesic 14 , antioxidant 15 , antitubercular, 16 antidepressant, 17 sedative, 18 antiamoebic, 19 oral analgesic, 20 anti-metabolite, 21 and antineoplastic properties. 22 For a extended analysis of the regiochemistry in 1,3-dipolar cycloaddition reaction and also the bioactivity of spiro [pyrrolidine-2,3'-oxindoline] compounds, three varieties of trapping agents like dipolarophiles, diketone, -amino acid, were introduced during this reaction to synthesis a series of spiro [pyrrolidine-2,3'-oxindole] derivatives, with that the bioactivity on anti-microbial activity was evaluated. In continuation of our research interests concerning the economical assembly of spiro-oxindoles ,we wish to report herein a 1,3-dipolar cycloaddition reaction involving enone segment (E)-3-aryl-1-(thiophen-2-yl)-prop-2-en-1-one to synthesize spiro oxindoles.…”

Section: Oriental Journal Of Chemistrymentioning

confidence: 99%

Design and synthesis of spiro derivatives containing a thiophene ring and evaluation of their Anti-microbial activity

Kanagaraju¹,

Thangamani²

2014

Orient J Chem

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Synthesis of a series of novel spiro pyrrolidines has been accomplished by 1, 3-dipolar cycloaddition reaction of azomethine ylide generated from phenylalanine and isatin with dipolarophiles in good yield. The reaction proceeded with high regio and stereoselectivity. The products have been characterized by elemental analyses and spectroscopic techniques, namely IR, 1 H NMR and 13 C NMR spectroscopies. Single crystal analysis of compounds 4k 2D-NMR analysis of compound 4k confirmed the structures of spiropyrrolidine derivatives. These compounds were evaluated for their antimicrobial activity. Most of the synthetic compounds exhibited good activity against microorganisms.

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“…5 TSCs and their metal complexes have many examples of pharmacological applications including antimalarial, antiviral, antiamoebic, antiprotozoal, antibacterial, antifungal and anticancer activities. [3][4][5][6][7][8] Their biological activities are considered to play a vital role in biological systems due to the TSCs to chelate with trace metal ions. 8,9 Optimization of these type molecules can result in discovery of new class therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

p-Cymene Based Organometallic Ruthenium(II)-Arene Complexes with Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity

Yavuz¹,

Yaman²,

Öztürk³

et al. 2017

Dicle Tıp Dergisi

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Objective: Thiosemicarbazone (TSC) containing three new mononuclear ruthenium(II)-arene complexes were synthesized so as to contribute to the development of ruthenium complexes with pharmacologically attracted properties.Conclusion: The TSC 1-3 containing ruthenium(II)-arene complexes were successfully synthesized and their molecular structures were also determined by the spectroscopic methods. All ruthenium(II)-arene complexes showed higher antibacterial activities against Gram-positive bacterial strains than the Gram-negative ones. Original Article/Özgün AraştırmaKeywords: Half-sandwich Ru(II)-arene complexes, benzaldehyde thiosemicarbazone, p-cymene, antimicrobial activity, clinical isolate.Results: The spectroscopic data indicated that TSC 1 was bounded to the metal as a tridentate ligand with its thione sulfur atom, phenolic oxygen atom and azomethine nitrogen atom in the complex I, while TSC 2 and TSC 3 were bounded to metal center as bidentate manner through their thione sulfur atom and imine nitrogen (C=N) atom in the complexes II and III, respectively. The obtained antimicrobial activity results showed that these complexes efficiently inhibit the growth of Gram-positive bacterial strains.

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Copper(II) complexes with substituted thiosemicarbazones of thiophene-2-carboxaldehyde: synthesis, characterization and antiamoebic activity against E. histolytica

Cited by 87 publications

References 25 publications

Synthesis and biological activity of acetylacetone thiosemicarbazone and their metallic complexes

Synthesis and biological activity of acetylacetone thiosemicarbazone and their metallic complexes

Design and synthesis of spiro derivatives containing a thiophene ring and evaluation of their Anti-microbial activity

p-Cymene Based Organometallic Ruthenium(II)-Arene Complexes with Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity

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