Copper(II) complexes with the non-steroidal anti-inflammatory drug tolfenamic acid: Structure and biological features

Nickel-diflunisal complexes: synthesis, characterization, in vitro antioxidant activity and interaction with DNA and albumins

“…The albumin constants and parameters for diflunisal and its complexes 1-5. their Cu(II) analogues [6], while, compared to the K b constants of other Ni-NSAID [42,43] complexes (Table S2), they are similar and in the range found for a series of previously reported metal-NSAID complexes [44][45][46][47][48][49][50]. Cyclic voltammetry may be used complimentarily to spectroscopic techniques providing useful information for the interaction mode of metal ions or metal complexes with DNA [94].…”

“…S4) and are cited in Table 5. The K constants of all complexes 1-5 are relatively high and are of the same magnitude with those calculated for a series of metal complexes with NSAIDs as ligands [6,[43][44][45][46][47][48][49][50]. The complexes exhibit for BSA similar or lower affinity than free Hdifl with complex 1 having the highest K constant (K (BSA),2 = 1.69(± 0.09) × 10 5 M −1 ) among the complexes, while the affinity of the complexes for HSA is higher than that of free Hdifl with complexes 3 and 4 bearing the highest K constants among the present compounds (K (HSA),3 = 2.68(± 0.20) × 10 5 M −1 and K (HSA),4 = 2.66(±0.17) × 10 5 M −1 ).…”

“…The k q constants of the complexes for HSA are higher than that of free Hdifl, with complex 4 showing the highest k q constant (k q(HSA),4 = 9.87(±0.57) × 10 12 M −1 s −1 ) while for BSA, in average) they are similar to that of free Hdifl and complex 1 bears the highest k q constant (k q(BSA),2 = 1.92(±0.05) × 10 13 M −1 s −1 ). The k q constant s of complexes 1-5 are within the range found for a series of metal-complexes bearing NSAIDs as ligands [6,[43][44][45][46][47][48][49][50].…”

“…As a continuation of our recent research studies concerning metal-NSAID complexes [6,[42][43][44][45][46][47][48][49][50], we have studied the interaction of Ni(II) with diflunisal in the absence or presence of the nitrogen-donor ligands 2,2′-dipyridylketone oxime (Hpko), 1,10-phenanthroline (phen), 2,2′-bipyridine (bipy) or 2,2′-bipyridylamine (bipyam) (Fig. 1).…”

Alkyl and aryl sulfonyl p-pyridine ethanone oximes are efficient DNA photo-cleavage agents

“…The values of the Stern-Volmer constant (K SV ) as calculated from the SternVolmer plots (Insets in Fig. 6) are 6.07(± 0.18) × 10 4 M − 1 for 3 and 3.72(± 0.10) × 10 4 M − 1 for 8; they may be considered rather high and verify the tight binding of compounds 3 and 8 to DNA [29,32]. Taking τ o = 23 ns as the fluorescence lifetime of EB-DNA system [33], the quenching constants of the compounds as calculated ; the values of the k q constants are significantly higher than 10 10 M −1 s −1 suggesting, thus, the quenching via a static mechanism [34].…”