Copper(II) hydrazone complexes with different nuclearities and geometries: Synthesis, structural characterization, antioxidant SOD activity and antiproliferative properties

Metal complexes of hydrazone–oxime derivative as promising in vitro antimicrobial agents against some fungal and bacterial strains

“…These chelators and their synthetic complex derivatives have enormous benefit to acquire varied applications in several fields. They have shown considerable antimalarial, 1 anti-insecticidal, 2 anticancer, 3 anticholinesterase, 4 antitumor, 5,6 anti-tuberculosis, 7 antifungal, [8][9][10][11] antibacterial, 8-11 antihyperglycemic, 12,13 anti-infective, 14 antiradical, 15 antioxidant, [16][17][18] antimicrobial, 19,20 antitrypanosome, 21 antidiabetic, anti-inflammatory, 22,23 antiviral, [23][24][25] antidepressant and nootropic, 26 and gastroprotective activities. 27 Furthermore, They act as enzyme inhibitors, 23,[28][29][30] catalysts in various reactions, [31][32][33] and excellent anticorrosion to protect the metals and alloys as steel.…”

Monometallic complexes of novel dihydrazone‐oxime ligand: Synthesis, structure, spectral, DFT, and in vitro bioactivity investigation against fungal, bacterial, and tumor cells

“…Schiff base ligands, particularly those with the hydrazide-hydrazone and oximatic moieties [(C=O) NHN=CH] and [(C=O)NHN=CC=NOH], have been discovered to be good pharmacophores for the design and development of a variety of bioactive compounds. [1][2][3][4][5] The compounds that incorporate hydrazide-hydrazone and/or oximatic moiety as well as their metal complexes are broadly employed in various applications such as anti-HIV, antihyperglycemic, [6,7] antifungal, [2][3][4] anticancer, [8] anti-tuberculosis, [9] anti-infective, [10] antitrypanosome, [11] insecticidal, [12] antibacterial, [2][3][4][5] antiradical, [13] anticholinesterase, [14] antitumor, [5,15,16] antioxidant, [17][18][19] antidepressant and nootropic, [20] antiinflammatory, [21,22] gastroprotective, [23] antimalarial, [24] antiviral activities, [22,25,26] and DNA cleavage. [27] Furthermore, these compounds also have the potential to be an excellent candidate for oral medicines, such as their use to treat genetic illnesses like thalassemia.…”

Copper(ii) complexes with terpene derivatives of ethylenediamine: synthesis, and antibacterial, antifungal and antioxidant activity

“…[7][8][9][10][11][12][13][14][15][16][17] Recently, much attention has been paid to the development and use of copper complexes with the superoxide dismutase (SOD) mimetic activity. [18][19][20][21][22][23][24] To test free-radicalscavenging properties of drugs is a promising protocol for enlarging the applicability of the clinic drugs. 25 Copper stands out among transition metals for its remarkable affinity for biological ligands and redox properties that make it an ideal metal to drive biochemical reactions involving redox and oxygen chemistry.…”