Copper(II)/Palladium(II) catalysed highly selective cross-coupling of terminal alkynes in supercritical carbon dioxide

Lignosulfonate/Dicationic Ionic Liquid Composite as a Task-Specific Catalyst Support for Enabling Efficient Synthesis of Unsymmetrical 1,3-Diynes with A Low Substrate Ratio

“…Increase of the ratio was helpful for the heterocoupling reaction, and when 1a / 2a was 5/1, yield of 3a reached 91% (entry 5). This observation is in a good accordance with the previous reports. − To ensure a good synthetic yield and also maximize the utilizing efficiency of substrate and the solvent for the product isolation, we continued the reactions with a ratio of 1a / 2a = 2/1. We suspected that, thanks to the formation of hydrogen bonds between alkynol and the solid support, alkynol component may be selectively enriched to some extent in the solid–liquid interface.…”

Green carbon–carbon homocoupling of terminal alkynes by a silica supported Cu(ii)-hydrazone coordination compound

“…16 Wang and co-workers reported the synthesis of unsymmetrical 1,3-diynes by using Cu( ii ) salt in supercritical-CO 2 as the solvent. 17 They used two different terminal alkynes in the presence of a tetramethylethylenediamine (TMEDA) base.…”

Efficient Ru-Catalyzed Electrochemical Homo- and Heterocoupling Reaction of Terminal Alkynes: Synthesis, In Vitro Anticancer Activity, and Docking Study

“…The coupling of terminal alkynes could achieve a diyne fragment substituted with various functionalities attached to both sides resulting in symmetrical or unsymmetrical 1,3-diynes. The straightforward synthesis of homocoupled 1,3-diynes was reported by Glaser–Eglinton–Hay–Cadiot–Chodkiewicz with adequate results. − In the standard synthesis of 1,3-diynes, copper is assigned to be an outstanding catalyst. − Apart from that, some bimetallic metal additives with copper were used for the preparation of 1,3-diynes from different alkyne sources. − In addition to that, some nanocomposites, − charge-transfer catalysts, and visible light-induced , reaction media acted as active catalysts to afford these diyne building blocks. Likewise, there are numerous methodologies that exist in the literature for the synthesis of 1,3-diyne moieties. − However, the push for this methodology is still continuing and under strong consideration by various academia along with pharmaceutical industries.…”