Copper in Infant Nutrition: Safety of World Health Organization Provisional Guideline Value for Copper Content of Drinking Water

Olivares, Manuel; Pizarro, Fernando; Speisky, Hernán; Lönnerdal, Bo; Uauy, Ricardo

doi:10.1097/00005176-199803000-00003

Cited by 90 publications

(83 citation statements)

References 27 publications

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“…If one compares the example of an adult who developed severe cirrhosis after 3 y exposure to 0.5 -1.0 mg Cu=kg=day (O'Donohue et al, 1993, to that physiological Cu intake during the first 6 months of life (0.4 -0.4 mg Cu=kg=day) one feels tempted to speculate that a healthy infants might be less sensitive to high Cu exposure than the adult liver, in spit of its underdeveloped Cu excretion capacity. Correspondingly, a prospective exposure study involving 128 infants than 3 months (Olivares et al, 1998) and the analysis of copper exposure in 1178 children older than 9 months of age (Pettersson & Rasmussen, 1999) did not indicate any particular sensitivity to Cu in those children. Despite daily administration of 2 mg Cu=L (Olivares et al, 1998) or an estimated load of up to 3.2 mg Cu=day with the drinking water (Pettersson & Rasmussen, 1999) no signs of liver damage were observed in the exposed children.…”

Section: Hohenheim Consensus Workhop K Schümann Et Almentioning

confidence: 90%

“…Correspondingly, a prospective exposure study involving 128 infants than 3 months (Olivares et al, 1998) and the analysis of copper exposure in 1178 children older than 9 months of age (Pettersson & Rasmussen, 1999) did not indicate any particular sensitivity to Cu in those children. Despite daily administration of 2 mg Cu=L (Olivares et al, 1998) or an estimated load of up to 3.2 mg Cu=day with the drinking water (Pettersson & Rasmussen, 1999) no signs of liver damage were observed in the exposed children. However, none of these studies included the critical age group of infants younger than 3 months, who might be particularly sensitive to Cu.…”

Section: Hohenheim Consensus Workhop K Schümann Et Almentioning

confidence: 90%

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Hohenheim Consensus Workshop: Copper

Schümann¹,

Classen

Dieter

et al. 2002

Eur J Clin Nutr

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Copper (Cu) is an essential trace element with many physiological functions. Homeostatic mechanisms exist to allow Cu to act as a cofactor in enzymatic processes and to prevent accumulation of Cu to toxic levels. The aim of this commentary is to better understand the role of dietary Cu supply in deficiency and under physiological and pathological conditions. The essentiality of Cu can be attributed to its role as a cofactor in a number of enzymes that are involved in the defence against oxidative stress. Cu, however, has a second face, that of a toxic compound as it is observed with accumulating evidence in hepatic, neurodegenerative and cardiovascular diseases. The destructive potential of Cu can be attributed to inherent physico-chemical properties.The main property is its ability to take part in Fenton-like reactions in which the highly reactive and extremely deleterious hydroxyl radical is formed. Diseases caused by dietary Cu overload could be based on a genetic predisposition. Thus, an assessment of risk-groups, such as infants with impaired mechanisms of Cu homeostasis regarding detoxification, is of special interest, as their Cu intake with resuspended formula milk may be very high. This implies the need for reliable diagnostic markers to determine the Cu status. These topics were introduced at the workshop by the participants followed by extensive group discussion. The consensus statements were agreed on by all members. One of the conclusions is that a re-assessment of published data is necessary and future research is required.

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Section: Hohenheim Consensus Workhop K Schümann Et Almentioning

confidence: 90%

Section: Hohenheim Consensus Workhop K Schümann Et Almentioning

confidence: 90%

Hohenheim Consensus Workshop: Copper

Schümann¹,

Classen

Dieter

et al. 2002

Eur J Clin Nutr

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“…Few studies have investigated the long term health effects of excess copper intake, but limited evidence suggests individuals with abnormal copper homeostasis (e.g., Wilson's Disease) may be more susceptible to copper toxicity. No effects on liver function have been found in infants consuming water with 2 mg/L of copper (Olivares et al 1998;, although evidence for this vulnerable population is limited. In healthy persons, case reports suggest liver and kidney damage can occur at very high ingestion levels over long periods of time (e.g., 30 mg per day for 3 years) (Stern 2010 and absorption rates and greater neurological vulnerability.…”

Section: Assessment General Health Effects Of Copper and Leadmentioning

confidence: 99%

Investigating elevated copper and lead levels in school drinking water

Barn

Nicol

Struck

et al. 2013

Environ. Health Rev.

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Copper and lead continue to be detected at levels above drinking water guidelines in Canadian schools. Although water is typically not an important source of these metals, intermittent use and corrosive water can cause copper and lead to leach from plumbing. Exposure to elevated copper levels is linked to acute gastrointestinal effects in the short term and possible liver effects in the long term, whereas even low level lead exposures are associated with neurodevelopmental effects. Because school water is not regularly monitored for corrosion metals, elevated concentrations are often brought to the attention of public health officials through unexpected circumstances. Here, the death of salmon eggs in a classroom aquarium triggered an investigation that found elevated levels of copper and lead in the school's drinking water. The investigation was then expanded to the school district. Copper and lead levels varied considerably across schools as well as in outlets located in the same school. The effectiveness of flushing, which was implemented as a mitigation strategy, was also found to differ by school building and outlet. Actions described in this case report may be informative for health authorities across Canada.

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“…However, Cu is toxic in higher concentrations (Pettersson and Rasmussen, 1999). For human consumption, the need for different trace metals is stipulated by the World Health Organization (WHO, 1996) and a moderate consumption of beer can contribute to the intake of Cu (Pohl, 2008;Olivares et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of copper content in beers obtained from retail in Sweden

Osorio-MacÃas¹,

PeÃ±arrieta²

2017

J. Brew. Distilling

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A quantitative study of copper (Cu) content in 19 different beer brands produced in mainly European countries and consumed in Sweden were measured using atomic absorption spectrophotometer without sample digestion. Results showed that the Cu content in beers is below the permissible levels concentrations for potable drinking water recommended by World Health Organization. In addition, the studies indicated that there is no correlation between the amount of Cu content in beers and their respective hops Cu content.

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Copper in Infant Nutrition: Safety of World Health Organization Provisional Guideline Value for Copper Content of Drinking Water

Cited by 90 publications

References 27 publications

Hohenheim Consensus Workshop: Copper

Hohenheim Consensus Workshop: Copper

Investigating elevated copper and lead levels in school drinking water

Evaluation of copper content in beers obtained from retail in Sweden

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