Copper in Mammalian Reproduction

Oster, Gérald; Salgo, Miklos

doi:10.1016/s1054-3589(08)60191-x

Cited by 26 publications

(26 citation statements)

References 381 publications

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“…Certain side effects of oral contraceptives have been attributed to chronic increase in serum ceruloplasmin. The oestrogen component is mainly responsible for the increased level of serum ceruloplasmin while progesterone causes a less drastic rise (5). Considering the operon concept of Monod and Jacob oestrogen act as an inducer for synthesis of ceruloplasmin RNA templates causing subsequent increase in synthesis of the protein (10).…”

Section: Discussionmentioning

confidence: 99%

“…According to Stich et al the cupric ion catalysed oxidation of ascorbate can induce mutation and DNA damage (5). This could possibly be the mechanism by which long term use of oral contraceptives can give rise to carcinogenic effects and cervical dysplasia.…”

Section: Discussionmentioning

confidence: 99%

“…The case distribution was as follows: - Particular age group was chosen as most of the women in this age group use contraception, otherwise there is no age related variation after two years of age (5). The day of sample collection is important as the serum ceruloplasmin levels change during different phases of menstruation by 10 -20 mg% (8).…”

Section: Methodsmentioning

confidence: 99%

“…It oxidizes a variety of amines including epinephrine, melatonin, serotonin, paraphenylene diamine (4). It also converts ferrous ion to ferric ions and hence is required for utilization of iron, hence also known as ferroxidase I (5). The other substrate which is vutnerable to the prooxidant activity of ceruloplasmin is vitamin C or ascorbic acid.…”

Section: Introductionmentioning

confidence: 99%

“…Osaki and Mc dermott proved the distinct ascorbate oxidase activity of ceruloplasmin (6). On the contrary, high levels of vit.C inhibit copper absorption by preventing its binding with metallothionine ( 4 ).This aspect has a bearing on the hazards of using oral contraceptives (1,5,7).…”

Section: Introductionmentioning

confidence: 99%

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Changes in serum ceruloplasmin levels with commonly used methods of contraception

Sontakke

2004

Indian J Clin Biochem

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It is a well established fact that long term use of oral contraceptives is hazardous to health. The most common methods of contraception used by women in reproductive age group include use of oral contraceptives and copper ' T '. One of the causative factors for the side effects of the ' pill' is presumed to be increase in serum cereloplasmin levels which has pro -oxidant activity. The present study involves the study of serum ceruloplasmin levels in two groups of subjects i.e. 30 women using oral contraceptive and 30 women using copper' T '. 30 healthy females in reproductive age group were chosen as controls. It was observed that oral contraceptives increase the serum ceruloplasmin levels (p < 0.001) and the difference is highly significant as compared to no change (p < 0.1) in the groups using copper ' T ' as contraceptives.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Changes in serum ceruloplasmin levels with commonly used methods of contraception

Sontakke

2004

Indian J Clin Biochem

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Size‐Dependent Inhibition of Sperm Motility by Copper Particles as a Path toward Male Contraception

Chattopadhyay

Magdanz

Hernández-Meliá

et al. 2022

Advanced NanoBiomed Research

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Teratogenic action of a bis(dichloroacetyl)diamine on rats: Patterns of malformations produced in high incidence at time‐limited periods of development

1978

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Win 18,446, a bis(dichloroacetyl)diamine, is a drug that was previously shown to suppress spermatogenesis and to be an effective oral abortifacient in rats. The present study shows that the drug is capable of producing characteristic congenital malformations in high incidence, by a single treatment, and with high survival of fetuses to day 21. Gestation day 11 is the most sensitive time. The teratologies obtained after various schedules of treatment include malformations of the snout (100%), septal heart defects (100%) diaphragmatic hernias (100%), cryptorchism (100%), cervical pockets (100%) and absent or small irregular thymus (92%). Some of these data, namely of the heart, face and thymus, cluster in patterns that indicate that the action of the drug is upon a time-resistricted developmental process. These periods of sensitivity are subsiding or have ended before primordia of these structures appear, but they coincide with the proliferation and migration of those mesenchyme cells that will eventually form or contribute to the structures affected. It is postulated that the drug acts on these mesenchyme cells, or on the extracellular matrix that provides the necessary framework for their dispersal.

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Copper in Mammalian Reproduction

Cited by 26 publications

References 381 publications

Changes in serum ceruloplasmin levels with commonly used methods of contraception

Changes in serum ceruloplasmin levels with commonly used methods of contraception

Size‐Dependent Inhibition of Sperm Motility by Copper Particles as a Path toward Male Contraception

Teratogenic action of a bis(dichloroacetyl)diamine on rats: Patterns of malformations produced in high incidence at time‐limited periods of development

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