Copper incorporation by low-energy ion implantation in PEO-coated additively manufactured Ti6Al4V ELI: Surface microstructure, cytotoxicity and antibacterial behavior

Baldin, Estela Kerstner; Castro, Victor Velho de; Santos, Pedro Bell; Aguzzoli, César; Bernardi, Fabiano; Medeiros, Thallyson; Maurmann, Natasha; Pranke, Patrícia; Frassini, Rafaele; Roesh, Mariana Ely; Longhitano, Guilherme Arthur; Munhoz, André Luiz Jardini; Andrade, Ankilma do Nascimento; Malfatti, Célia de Fraga

doi:10.1016/j.jallcom.2023.168735

Cited by 7 publications

(2 citation statements)

References 50 publications

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“…In a research study conducted by our team [34], we used the IPD technique to implant copper ions onto surfaces that were coated with PEO (Plasma Electrolytic Oxidation) on the Ti6Al4V ELI alloy. This alloy was manufactured using the Direct Metal Laser Sintering (DMLS) additive manufacturing process.…”

Section: Copper Ion Implantationmentioning

confidence: 99%

Antibacterial Surfaces Treated with Metal Ions Incorporation by Low-Energy Ionic Ion Implantation: An Opinion

de Fraga Malfatti,

de Castro,

Bullmann

et al. 2024

J Biomed Res Environ Sci

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Infectious diseases have been a huge obstacle to human survival for centuries. Despite scientific progress, bacterial infections continue to be among the leading causes of death and disability worldwide. Thus, surface functionalization of materials can be a viable strategy to prevent biofilm formation. In this way, metal ions incorporation, such as silver (Ag+), copper (Cu2+), or zinc (Zn2+), have been proposed due to their antimicrobial properties, and low-energy ionic ion implantation (IPD) as promising alternative surface treatment process. Therefore, this article briefly reports on recent developments in this technique in surface functionalization for antibacterial action. Furthermore, it seeks to point out perspectives for applying the technique and points for improvement for this technology.

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Section: Copper Ion Implantationmentioning

confidence: 99%

Antibacterial Surfaces Treated with Metal Ions Incorporation by Low-Energy Ionic Ion Implantation: An Opinion

de Fraga Malfatti,

de Castro,

Bullmann

et al. 2024

J Biomed Res Environ Sci

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“…[ 3 ] In America, it is estimated that more than 100 000 deaths per year are caused by implant‐related bacterial infections. [ 4 ] In ordinary circumstances, the pathogenic bacteria that invade the body can be effectively removed by the patient's immune defense system. However, implant‐related infections are often accompanied by chronic inflammation and microphage bactericidal activity is compromised by reductions in interleukin (IL)‐1 production and the major histocompatibility complex (MHC) expression activity of neutrophils, lymphocytes, and monocytes, thus further resulting in local immunosuppression and persistent and recurring infections.…”

Section: Introductionmentioning

confidence: 99%

Environment‐Responsive Therapeutic Platforms for the Treatment of Implant Infection

Dong

et al. 2023

Adv Healthcare Materials

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The application of medical implants has greatly improved the survival rate and life quality of patients. Nevertheless, in recent years, there are increasing cases of implant dysfunction or failure because of bacterial infections. Despite significant improvements in biomedicine, there are still serious challenges in the treatment of implant‐related infections. With the formation of bacterial biofilms and the development of bacterial resistance, these limitations lead to a low efficacy of conventional antibiotics. To address these challenges, it is urgent to exploit innovative treatment strategies for implant‐related infections. Based on these ideas, environment‐responsive therapeutic platforms with high selectivity, low drug resistance, and minor dose‐limiting toxicity have attracted widespread attention. By using exogenous/endogenous stimuli, the antibacterial activity of therapeutics can be activated on demand and exhibit remarkable therapeutic effects. Exogenous stimuli include photo, magnetism, microwave, and ultrasound. Endogenous stimuli mainly include the pathological characteristics of bacterial infections such as acidic pH, anomalous temperature, and abnormal enzymatic activities. In this review, the recent progress of environment‐responsive therapeutic platforms with spatiotemporally controlled drug release/activation is systematically summarized. Afterward, the limitations and opportunities of these emerging platforms are highlighted. Finally, it is hoped that this review will offer novel ideas and techniques to combat implant‐related infections.

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Ce-doped defective titanium oxide coating with antibacterial, antioxidant and anti-inflammatory properties for potential application of peri-implantitis treatment

Chen,

Guan,

Xing

et al. 2024

Rare Met.

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Copper incorporation by low-energy ion implantation in PEO-coated additively manufactured Ti6Al4V ELI: Surface microstructure, cytotoxicity and antibacterial behavior

Cited by 7 publications

References 50 publications

Antibacterial Surfaces Treated with Metal Ions Incorporation by Low-Energy Ionic Ion Implantation: An Opinion

Antibacterial Surfaces Treated with Metal Ions Incorporation by Low-Energy Ionic Ion Implantation: An Opinion

Environment‐Responsive Therapeutic Platforms for the Treatment of Implant Infection

Ce-doped defective titanium oxide coating with antibacterial, antioxidant and anti-inflammatory properties for potential application of peri-implantitis treatment

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