Copper induced immunomodulation in the marine mussel, Mytilus edulis

Pipe, R.K.; Coles, Jackie A.; Carissan, F.M.M; Ramanathan, Kadirvel

doi:10.1016/s0166-445x(98)00114-3

Cited by 208 publications

(121 citation statements)

References 45 publications

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“…The work by Sami et al (1992) supports the hypothesis that changes at the surface of the plasma membrane could affect phagocytosis in invertebrate haemocytes exposed to contaminants. Research on lectin binding and contaminant exposure in invertebrates has, to date, been minimal, but recent work has shown that reduced binding of snowdrop Galanthus nivalis lectin and snail Helix pomatia lectin occurs in mussels exposed experimentally to the inorganic contaminant copper (Pipe et al 1999).…”

Section: Discussionmentioning

confidence: 99%

Changes in immune parameters of natural mussel Mytilus edulis populations following a major oil spill ('Sea Empress', Wales, UK)

Dyrynda¹,

Law²,

Dyrynda³

et al. 2000

Mar. Ecol. Prog. Ser.

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In February 1996, the oil tanker 'Sea Empress' spilt over 70 000 t of crude oil which contaminated ca 200 km of coastline (Milford Haven, Wales, UK). The effects of the oil on immunity in mussels Mytilus edulis were investigated in parallel with the measurement of hydrocarbon contamination in the tissues. Initially, severe immunosuppression occurred in oiled mussels, corresponding with very high polycyclic aromatic hydrocarbon (PAH) levels. The haemocytes of mussels from oiled sites showed significantly reduced superoxide generation and phagocytic activity, effects likely to have deleterious consequences for successful disease resistance. As contaminant levels decreased, the immunosuppression became less extreme and recovery was evident by May 1996. Between October 1996 and March 1997, immune activity in the haemocytes of the previously oiled mussels was again significantly reduced, coinciding with increased PAH levels. During this latter period, certain high molecular mass PAHs (characteristically derived from combustion processes) were primarily responsible for the increase, occurring at similar concentrations in the mussel tissues to those observed just after the spill. A subsequent reduction of hydrocarbons in June 1997 was followed by another, but less marked, increase in PAHs between October 1997 and March 1998, coupled with only minimal changes in immunity. The results show that immunosuppression following the oil spill was severe, but that recovery followed a few months later and the initial effects were not therefore permanent. The results also suggest that seasonal peaks in combustion-derived PAHs may occur in the region and that these would have been greatly exacerbated early in 1996 by oil released from the 'Sea Empress'. KEY WORDS: Mytilus · Immune defence · Haemocyte · Oil spill · Hydrocarbon contaminationResale or republication not permitted without written consent of the publisher Mar Ecol Prog Ser 206: 155-170, 2000 These include the induction of biomarker enzymes in fish and molluscs (Sole et al. 1996, Woodin et al. 1997, Stagg et al. 1998, Kirby et al. 1999, abnormalities in fish embryos/larvae (Hose et al. 1996, Bue et al. 1998 and haematological changes in vertebrates (Duffy et al. 1994, Walton et al. 1997.Despite the considerable effects that crude oil contaminants can exert on the physiology of marine animals, information concerning impacts on the physiology of natural invertebrate populations is more limited, particularly with respect to their immune defences. Globally, marine invertebrates constitute an important economic resource, and factors influencing their ability to resist disease and hence maintain healthy populations are of considerable relevance. Invertebrate immune defences comprise cellular and humoral components, which are highly efficient in combating pathogens and parasites and share many facets with vertebrate immune defences (Ratcliffe et al. 1985, Engstrøm et al. 1993. Laboratory exposure to contaminants can significantly alter immunity in invertebrates fr...

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Section: Discussionmentioning

confidence: 99%

Changes in immune parameters of natural mussel Mytilus edulis populations following a major oil spill ('Sea Empress', Wales, UK)

Dyrynda¹,

Law²,

Dyrynda³

et al. 2000

Mar. Ecol. Prog. Ser.

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“…Cellular viability (cell integrity and function) has been used to assess the sub-lethal effects of contaminant exposure to Mytilus edulis (Hagger et al 2005) and Patella vulgata (Bloxham et al 2004). The phagocytosis assay has been widely used to investigate effects of chemical toxicants on the immune systems of marine animals (Galloway & Goven iin press), and exposure to copper has been shown to suppress the immune systems of the mussels M. edulis (Pipe et al 1999) and Perna virdis (Nicholson 2003). Such contaminant-mediated reductions in immunological function may reduce survivorship by increasing the risk of infections from marine pathogens.…”

Section: Introductionmentioning

confidence: 99%

Ecologically relevant effects of pulse application of copper on the limpet Patella vulgata

Cartwright¹,

Coleman²,

Browne³

2006

Mar. Ecol. Prog. Ser.

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“…However, PAHs can alter the fluidity of cell membranes [46] and restrict membrane deformation, which is essential to phagocytic endocytosis [28]. This result is supported by observations on the effects of a low-dose, short-term stimulation of phagocytosis on the bivalve response to contaminants such as diesel, metals [63,70], water from industrial sources [31], and pesticides [66].…”

Section: Immunity Responses Of P Martensii To Pyrenementioning

confidence: 66%

Effects of pyrene exposure on immune response and oxidative stress in the pearl oyster, Pinctada martensii

Xie

Zhao

Han

et al. 2017

Fish & Shellfish Immunology

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a b s t r a c tPyrene is a polycyclic aromatic hydrocarbon (PAH) commonly observed in aquatic ecosystems, which originates primarily from the incomplete combustion of fossil fuels and the use of petroleum compounds. Pyrene can cause the immune disturbance and oxidative stress, result in immunotoxicity, DNA damage, reduce reproduction significantly, and induce behavioral changes. Marine bivalves are commonly used as bioindicators for marine pollution, and hemolymph is a metabolite transfer medium for PAH pollutant. However, the vital immune indicator responses of pearl oyster Pinctada martensii hemolymph exposed to pyrene is still unclear. Thus, the immunotoxic responses of pyrene on the hemolymph of the Pinctada martensii were investigated in this study. After exposure to pyrene for 7 days, the total number of hemocytes (THC), cell membrane stability (CMS), phagocytic activity (PA) and total glutathione (GSH T ) all decreased significantly. Pyrene also caused a significant increase in lipid peroxi- ) and GSH T (7.2 mg L À1 ), which indicates that THC and LPO were more sensitive. Additionally, a clear dose-effect relationship indicated that pyrene stimulated a marked immune response, as well as oxidative stress in P. martensii, which demonstrates the subtle effects of pyrene exposure on marine invertebrates and the potential associated risk.

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Copper induced immunomodulation in the marine mussel, Mytilus edulis

Cited by 208 publications

References 45 publications

Changes in immune parameters of natural mussel Mytilus edulis populations following a major oil spill ('Sea Empress', Wales, UK)

Changes in immune parameters of natural mussel Mytilus edulis populations following a major oil spill ('Sea Empress', Wales, UK)

Ecologically relevant effects of pulse application of copper on the limpet Patella vulgata

Effects of pyrene exposure on immune response and oxidative stress in the pearl oyster, Pinctada martensii

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