2024
DOI: 10.1101/2024.11.07.622423
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Copper induces p53 unfolding in cancer cells, resulting in invasion and chemoresistance

Yannick von Grabowiecki,
Steven J Bell,
Hannah L Richards
et al.

Abstract: Copper has been shown to play an important role in cancers, enhancing cell proliferation, remodelling the microenvironment and enhancing the function of oncogenes. Here we show that copper turns the tumour suppressor p53 protein into a pro-oncogenic protein. Mutations in the TP53 gene often lead to expression of various mutant p53 proteins. Mutant proteins often lose some or all wild type function and gain novel pro-tumourigenic functions, which can be partially attributed to protein unfolding. Here we show th… Show more

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