Copper ion (Cu2+) is involved in the transcription of the tyrosinase-encoding <i>melB</i> gene of <i>Aspergillus oryzae</i> in solid-state culture

Chen, Jun; Tonouchi, Akio

doi:10.1093/bbb/zbad162

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…Solid-state culture is a commonly used industrial method to cultivate A. oryzae cells to produce industrial enzymes, as secretory proteins are produced to a greater extent in solid-state culture compared with submerged culture [86]. However, there are certain proteins that are not secreted in solid-state culture, unlike submerged culture, such as the glucoamylase-encoding gene glaB [87]. These findings suggest that there is a molecular mechanism governing protein secretion in A. oryzae.…”

Section: Molecular Mechanism For Protein Secretion In a Oryzaementioning

confidence: 99%

Aspergillus oryzae as a Cell Factory: Research and Applications in Industrial Production

Sun,

Wu,

Long

et al. 2024

JoF

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Aspergillus oryzae, a biosafe strain widely utilized in bioproduction and fermentation technology, exhibits a robust hydrolytic enzyme secretion system. Therefore, it is frequently employed as a cell factory for industrial enzyme production. Moreover, A. oryzae has the ability to synthesize various secondary metabolites, such as kojic acid and L-malic acid. Nevertheless, the complex secretion system and protein expression regulation mechanism of A. oryzae pose challenges for expressing numerous heterologous products. By leveraging synthetic biology and novel genetic engineering techniques, A. oryzae has emerged as an ideal candidate for constructing cell factories. In this review, we provide an overview of the latest advancements in the application of A. oryzae-based cell factories in industrial production. These studies suggest that metabolic engineering and optimization of protein expression regulation are key elements in realizing the widespread industrial application of A. oryzae cell factories. It is anticipated that this review will pave the way for more effective approaches and research avenues in the future implementation of A. oryzae cell factories in industrial production.

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Section: Molecular Mechanism For Protein Secretion In a Oryzaementioning

confidence: 99%

Aspergillus oryzae as a Cell Factory: Research and Applications in Industrial Production

Sun,

Wu,

Long

et al. 2024

JoF

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An investigation into the transcription factors and regulatory mechanisms of Aspergillus

Qin,

Yu,

Tian

2024

Food Safety and Health

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Aflatoxins produced by Aspergillus flavus, a group of filamentous fungi widely distributed in nature as foodborne pathogens, are a major threat to food safety. It is thus clear that Aspergillus is inextricably linked to the food sector. Transcription factors enable the correct expression of genes at specific spatial and temporal levels, and they constitute a considerable proportion of the fungal genome sequence. Their presence is particularly important for growth, secondary metabolism, stress response, and pathogenic process of Aspergillus. This article reviews the functional regulatory mechanisms of important transcription factors in the foodborne pathogen Aspergillus flavus and other Aspergillus species, the current status of research technologies, and the potential value of applying them to diverse fields such as food safety, biotechnology, medical health, and agricultural output in the future.

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Copper ion (Cu2+) is involved in the transcription of the tyrosinase-encoding melB gene of Aspergillus oryzae in solid-state culture

Cited by 2 publications

References 23 publications

Aspergillus oryzae as a Cell Factory: Research and Applications in Industrial Production

Aspergillus oryzae as a Cell Factory: Research and Applications in Industrial Production

An investigation into the transcription factors and regulatory mechanisms of Aspergillus

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