Copper Levels in Human Tissue

Cross, Jamie; Leslie, A.C.D.; Smith, Hamilton

doi:10.1016/s0015-7368(76)71078-8

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…Given the concentrations of PS (variable, but generally micromolar to low millimolar) and Cu + /Cu 2+ (also variable, but ∼100 μM is often noted in the literature) found in cells and the tight binding observed in this work, it seems reasonable that, at least under some conditions, Cu 2+ could exist in 1:2 Cu 2+ –PS complexes in vivo . The distributions of both copper and PS in various cell and tissue types are often seen to roughly track one another, both being present in relatively high concentrations, for example, in human brain tissue. , Thus, increased PS may serve to complex and neutralize otherwise reactive Cu 2+ in tissues that experience high Cu 2+ concentrations. This complexation ability may be particularly important in mitigating copper poisoning.…”

Section: Discussionmentioning

confidence: 99%

“…The distributions of both copper and PS in various cell and tissue types are often seen to roughly track one another, both being present in relatively high concentrations, for example, in human brain tissue. 42,43 Thus, increased PS may serve to complex and neutralize otherwise reactive Cu 2+ in tissues that experience high Cu 2+ concentrations. This complexation ability may be particularly important in mitigating copper poisoning.…”

Section: ■ Discussionmentioning

confidence: 99%

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Phosphatidylserine Reversibly Binds Cu²⁺ with Extremely High Affinity

et al. 2012

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Phosphatidylserine (PS) embedded within supported lipid bilayers (SLBs) was found to bind Cu2+ from solution with extraordinarily high affinity. In fact, the equilibrium dissociation constant was in the femtomolar range. The resulting complex formed in a 1:2 Cu2+ to PS ratio and quenches a broad spectrum of lipid-bound fluorophores in a reversible and pH-dependent fashion. At acidic pH values, the fluorophores were almost completely unquenched, while at basic pH values significant quenching (85–90%) was observed. The pH at which the transition occurred was dependent on the PS concentration and ranged from approximately pH 5 to 8. The quenching kinetics was slow at low Cu2+ concentrations and basic values pH (up to several hours), while the unquenching reaction was orders of magnitude more rapid upon lowering the pH. This was consistent with diffusion limited complex formation at basic pH, but rapid dissociation under acidic conditions. The tight binding of Cu2+ to PS may have physiological consequences under certain circumstances.

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Section: Discussionmentioning

confidence: 99%

Section: ■ Discussionmentioning

confidence: 99%

Phosphatidylserine Reversibly Binds Cu²⁺ with Extremely High Affinity

et al. 2012

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“…159 In a suicide case by ingestion of a 30% O1SO4 solution, the copper concentrations in the brain, liver, stomach, and especially hair roots and urine increased significantly. According to Cross et al, 160 hair levels reflect the blood levels at the time of growth.…”

Section: G the Acute Toxicity Of Coppermentioning

confidence: 99%