Copper Levels in Indian Childhood Cirrhosis

Abdulla, M.; Dang, H.S.; Somasundaram, Shanmugam S

doi:10.1016/s0140-6736(79)90252-6

The Lancet

1979

DOI: 10.1016/s0140-6736(79)90252-6

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Copper Levels in Indian Childhood Cirrhosis

M. Abdulla

H.S. Dang²,

Shanmugam S Somasundaram³

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Cited by 3 publications

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Blood levels of copper, iron, zinc, and lead in adults in India and Pakistan and the effect of oral zinc supplementation for six weeks

Abdulla¹,

Suck

1998

Biol Trace Elem Res

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Deficiency in the intake of trace elements, such as copper (Cu), iron (Fe), selenium (Se), and zinc (Zn), is very common in the general population of most developing countries. A preliminary study in India and Pakistan showing the plasma levels of Zn and Fe indicates that approx 50% of the subjects who participated have low levels of both Fe and Zn, suggesting a marginal deficiency. The low plasma levels of these elements are more pronounced in females. The mean levels of Ze, Cu, and Fe in the plasma of 83 subjects were 0.71 +/- 0.11, 0.96 +/- 0.10, and 0.80 +/- 0.12 mg/L, respectively. The Cu:Zn ratio in the plasma was 1.43 +/- 0.16. Three groups of 15 subjects each were given three different levels of oral supplements of Zn (15, 30, and 45 mg of Zn as Zn gluconate) for 6 wk, and blood samples were analyzed during various intervals. Plasma concentration of Zn increased significantly (p < 0.001) in all the groups after 4 wk of supplementation and reached almost normal levels after 6 wk. Along with the increase in Zn, there was a significant decrease (p < 0.001) in plasma Cu levels. There were no changes in the concentration of Fe during the supplementation period. The supplementation was well tolerated by most subjects. The results of this pilot study indicate that Zn supplementation is a practical possibility comparable to that of Fe supplementation in order to prevent marginal Zn deficiency in vulnerable groups in the general population of developing countries.

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Blood levels of copper, iron, zinc, and lead in adults in India and Pakistan and the effect of oral zinc supplementation for six weeks

Abdulla¹,

Suck

1998

Biol Trace Elem Res

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First Description of “Indian Childhood Cirrhosis” in a Non‐Indian Infant in Europe

Weiß¹,

Müller‐Höcker²,

Wiebecke³

et al. 1989

Acta Paediatrica

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The first female child of healthy German parents, breast-fed for 5 weeks, developed progressive abdominal distension due to hepatosplenomegaly at the age of 7 months and died from acute liver failure 3 months later. Histology showed destruction of liver architecture with extreme hepatocellular copper storage, characteristic of "Indian childhood cirrhosis" (ICC). The family received drinking water from a well via copper pipes. The copper level of the water was extremely elevated (430 and 5510 micrograms/l) so that exogenous copper intake during the first months of life may have induced the fatal liver disease, probably in association with an unproven genetic disposition. This is the first description of a case of ICC in a member of a non-Indian family in Europe.

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Variation in the Distribution of Trace Elements in Hepatoma

Tashiro

Kawamoto

Okubo

et al. 2003

BTER

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There are many reports of reduction of zinc level and rise of copper level in serum of patients with liver disease. However, there are a few reports that compare the trace elements in tumor tissues and nontumor tissues of the liver with hepatoma. We studied trace element distribution in tumor tissues and nontumor tissues of liver with hepatoma and compared them with data from normal liver tissues. Zinc (Zn), copper (Cu), selenium (Se), cadmium (Cd), mercury (Hg), and iron (Fe) were chosen as the trace elements to be observed. We observed falls of Zn, Cd, and Hg levels in tumor tissues and the rise of Cu level as a result of this investigation. Zn, Cd, and Hg levels in tumor tissues were significantly lower than those in nontumor tissues and Zn, Cd, and Hg levels in nontumor tissues were significantly lower than in normal liver tissues. This tendency was clearer for Cd and Hg than for Zn. Although the distribution of Cu was not significant, a distribution contrary to that of Zn was shown. These findings indicate that the distribution of Zn, Cd, and Hg can serve as supportive evidence that could be useful as a tumor marker. Selenium showed almost the same accumulation tendency among tumor tissues, nontumor tissues, and normal livers. Although correlation was observed among most metals in the normal liver, there was almost no correlation in tumor tissues.

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Copper Levels in Indian Childhood Cirrhosis

Cited by 3 publications

References 4 publications

Blood levels of copper, iron, zinc, and lead in adults in India and Pakistan and the effect of oral zinc supplementation for six weeks

Blood levels of copper, iron, zinc, and lead in adults in India and Pakistan and the effect of oral zinc supplementation for six weeks

First Description of “Indian Childhood Cirrhosis” in a Non‐Indian Infant in Europe

Variation in the Distribution of Trace Elements in Hepatoma

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