Copper Metal–Organic Framework Nanoparticles Stabilized with Folic Acid Improve Wound Healing in Diabetes

Xiao, Jiaying; Zhu, Yunxiao; Huddleston, Samantha; Li, Peng; Xiao, Baixue; Farha, Omar K.; Ameer, Guillermo A.

doi:10.1021/acsnano.7b01850

Cited by 321 publications

(208 citation statements)

References 49 publications

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“…Zn 2+ has been reported to promote the expression of vascular endothelial growth factor (VEGF) [ 33 ]. Sustained release ion could exert better property with less toxic [ 34 , 35 ]. Besides, EGCG was reported to accelerate reepithelialization and angiogenesis [ [36] , [37] , [38] ].…”

Section: Discussionmentioning

confidence: 99%

ROS-responsive capsules engineered from EGCG-Zinc networks improve therapeutic angiogenesis in mouse limb ischemia

Chen

Duan

Diao

et al. 2021

Bioactive Materials

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The successful treatment of limb ischemia requires that promote angiogenesis along with microenvironment improvement. Zinc ions have been reported to stimulate angiogenesis, but application was limited to the toxicity concerns. We hypothesized that zinc based metal-EGCG capsule (EGCG/Zn Ps) can achieve sustained release Zn 2+ resulting in reduced toxicity and improve angiogenesis as well as the improvement of microenvironment by ROS scavenging of EGCG. The surface morphology, zeta potential, infrared absorbance peaks and zinc ion release profile of the EGCG/Zn Ps were measured. In vitro, EGCG/Zn showed significantly antioxidant, anti-inflammatory and induced cell migration effect. In addition, EGCG/Zn Ps enabled the sustained release of zinc ions, which reduced cytotoxicity and enhanced the secretion of vascular endothelial growth factor (VEGF) in vitro and in vivo. In mouse models of limb ischemia, EGCG/Zn Ps promoted angiogenesis and cell proliferation in ischemic tissues. Moreover, EGCG/Zn Ps group exhibited the most significant recovery of limb ischemic score, limb temperature and blood flow than other groups. In conclusion, EGCG/Zn Ps is a safe and promising approach to combine the merit of Zn 2+ and EGCG, thus enabling the direct application to limb ischemia.

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Section: Discussionmentioning

confidence: 99%

ROS-responsive capsules engineered from EGCG-Zinc networks improve therapeutic angiogenesis in mouse limb ischemia

Chen

Duan

Diao

et al. 2021

Bioactive Materials

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“…They could promote the angiogenesis and collagen deposition for promoting the healing of chronic nonhealing wounds as demonstrated in diabetic mice with splinted excisional dermal wounds. [181] These Cu-MOF nanoparticles were also embedded into citrate-based hydrogel with antioxidant thermo-responsive property for mitigating the toxicity of Cu ions and strengthening the wound-healing process. [43] Figure 19.…”

Section: Cu-involved Nanoagents For Tissue Engineeringmentioning

confidence: 99%

The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

et al. 2020

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As an essential trace element in the human body, transitional metal copper (Cu) ions are the bioactive components within the body featuring dedicated biological effects such as promoting angiogenesis and influencing lipid/glucose metabolism. The recent substantial advances of nanotechnology and nanomedicine promote the emerging of distinctive Cu‐involved biomaterial nanoplatforms with intriguing theranostic performances in biomedicine, which are originated from the biological effects of Cu species and the physiochemical attributes of Cu‐composed nanoparticles. Based on the very‐recent significant progresses of Cu‐involved nanotheranostics, this work highlights and discusses the principles, progresses, and prospects on the elaborate design and rational construction of Cu‐composed functional nanoplatforms for a diverse array of biomedical applications, including photonic nanomedicine, catalytic nanotherapeutics, antibacteria, accelerated tissue regeneration, and bioimaging. The engineering of Cu‐based nanocomposites for synergistic nanotherapeutics is also exemplified, followed by revealing their intrinsic biological effects and biosafety for revolutionizing their clinical translation. Finally, the underlying critical concerns, unresolved hurdles, and future prospects on their clinical uses are analyzed and an outlook is provided. By entering the “Copper Age,” these Cu‐involved nanotherapeutic modalities are expected to find more broad biomedical applications in preclinical and clinical phases, despite the current research and developments still being in infancy.

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“…Much simplified and chemically tunable precursors to directly achieve chemo‐photothermal antibacterial nanocarbons are highly needed to promote their applications in combating pathogenic bacteria. Recently, metal–organic frameworks (MOFs) have been demonstrated as a new class of multifunctional nanomaterials or precursors for applications in a wide range of fields . Besides utilizing the MOFs directly to serve as nanocarriers or biocatalysts for biomedical applications, MOF‐derived nanocarbons have also presented intriguing physical and chemical properties, such as high photothermal conversion efficiency, facile doping of metal atoms, and large surface area with porous structures …”

Section: Introductionmentioning

confidence: 99%

Size‐Transformable Metal–Organic Framework–Derived Nanocarbons for Localized Chemo‐Photothermal Bacterial Ablation and Wound Disinfection

Yang

Deng

Huang

et al. 2019

Adv Funct Materials

114

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Severe infectious diseases caused by pathogenic bacteria have become urgent threats to global public health. Antibacterial materials with combined chemophotothermal therapeutic capabilities possess distinct advantages when compared with many other antibacterial approaches. However, developing simplified and chemically tunable precursors to synthesize such antibacterial nanoagents for rapidly, safely, and synergistically combating pathogenic bacteria remains a huge challenge. Herein, metal-organic framework (MOF)-derived nanocarbons with near-infrared (NIR)-responsive and sizetransformable capabilities are designed to overcome this challenge. The MOF-derived nanocarbons with chemo-photothermal bactericidal capabilities are first synthesized, and then coated with a thermoresponsive gel layer to obtain ON-OFF switching capability for bacterial trapping. The fabricated nanocarbons exhibit high photo-to-thermal conversion efficiency and fast size transformation from nanodispersions to micrometer aggregations upon NIR irradiation, thus enabling nanocarbons to generate localized massive heat and abundant Zn 2+ ions for directly disrupting bacterial membrane and intracellular proteins. Furthermore, these nanocarbons not only exhibit a nearly 100% bactericidal ratio at very low dosage, but also possess highly efficient and safe wound disinfection activities, which are comparable to vancomycin. Overall, these proposed novel nanocarbons display robust and localized chemo-photothermal bactericidal capability and possess great potential to be used as alternative to antibiotics for broad-spectrum eradication of pathogenic bacteria.

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Copper Metal–Organic Framework Nanoparticles Stabilized with Folic Acid Improve Wound Healing in Diabetes

Cited by 321 publications

References 49 publications

ROS-responsive capsules engineered from EGCG-Zinc networks improve therapeutic angiogenesis in mouse limb ischemia

ROS-responsive capsules engineered from EGCG-Zinc networks improve therapeutic angiogenesis in mouse limb ischemia

The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

Size‐Transformable Metal–Organic Framework–Derived Nanocarbons for Localized Chemo‐Photothermal Bacterial Ablation and Wound Disinfection

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