Copper Nanoparticles as Antibacterial Agents

Mahmoodi, Shirin; Elmi, Asghar; Hallaj‐Nezhadi, Somayeh

doi:10.4172/2329-9053.1000140

Cited by 115 publications

(77 citation statements)

References 54 publications

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“…Plant extracts have been extensively employed as an efficient resource for the synthesis of materials 7,8,9 . The present study concentrated on biofabrication of CuNPs as they are shown to possess strong antibacterial capacity 10,11 .…”

Section: Resultsmentioning

confidence: 99%

Untitled

2020

IJPSR

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A major challenge in treating bacterial infections is the increasing incidence of microbial resistance to antibiotics. This poses a serious threat prompting the search for alternative strategies to treat bacterial infections. Metal nanoparticles as novel antibiotic agents hold promise because they show strong antibacterial activity against various bacterial species, including Gram-positive and Gram-negative bacteria. Green synthesis of nanoparticles offers minimization of wastage, reduction of derivatives, use of non-toxic solvent, auxiliaries and renewable feedstock. A single step, an eco-friendly, cost-effective method is used for the synthesis of copper nanoparticles (CuNPs) from 1.0 mM copper sulphate solution using extract of Ocimum sanctum (Tulsi) leaves as reducing and capping agent. UV-VIS, FESEM, FTIR and XRD were used to confirm and characterize the NPs. The biosynthesized copper NPs were phased pure and well crystalline with a simple cubic structure. Antibacterial study of the biogenic CuNPs suggests their efficacy against common human bacterial pathogen species. Gram-negative test organisms were found to be more susceptible to toxicity of biosynthesized CuNPs. Metal nanoparticles hold the promise to overcome microbial resistance due to their specific properties. QUICK RESPONSE CODE

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Section: Resultsmentioning

confidence: 99%

Untitled

2020

IJPSR

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“…It has been shown that the antimicrobial power of metal oxide nanoparticles is associated with the soluble ions of the metal Zn 2+ or Cu 2+ in the broth media (Chang, Zhang, Xia, Zhang, & Xing, 2012;Dimkpa, McLean, Britt, & Anderson, 2013;Hsueh, Tsai, & Lin, 2017). In addition, some studies mention that the toxicity of CuO NPs could be attributed to the particles and not only by the release of the soluble ions (Mahmoodi, Elmi, & Hallaj-nezhadi, 2018). In addition, some studies mention that the toxicity of CuO NPs could be attributed to the particles and not only by the release of the soluble ions (Mahmoodi, Elmi, & Hallaj-nezhadi, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Concentration and time exposure of the NPs correlates with toxicity because they release more ions, but the ambient conditions (e.g., pH, ionic strength) of the suspension also had an effect over their antimicrobial activity (Wang et al, 2016). In addition, some studies mention that the toxicity of CuO NPs could be attributed to the particles and not only by the release of the soluble ions (Mahmoodi, Elmi, & Hallaj-nezhadi, 2018).…”

Section: Discussionmentioning

confidence: 99%

In vitro antimicrobial effect of metallic nanoparticles on phytopathogenic strains of crop plants

Vera‐Reyes

Esparza‐Arredondo²,

Lira-Saldívar³

et al. 2019

Journal of Phytopathology

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In this research, the in vitro antimicrobial effect of zinc oxide (ZnO), copper oxide (CuO) and iron oxide (Fe2O3) nanoparticles (NPs)—with average sizes of 20, 46 and 30 nm, respectively—on the root rot disease caused by the fungus Fusarium oxysporum and on blight disease caused by the fungus Alternaria solani were studied. Also, bacterial diseases caused by Clavibacter michiganensis and Pseudomonas syringae that infects a wide range of plant species were assessed. Different concentrations of NPs (0, 100, 250, 500, 700 and 1,000 mg/L) were prepared on PDA agar or King's B medium in a complete randomized design with four replicates. According to the results, ZnO NPs exhibited an outstanding inhibitory effect against fungi and bacteria strains. The above results were associated with the smaller particle size. Fungi strains showed a differential sensitivity depending on the kind of NPs used. A. solani showed the highest sensitivity to ZnO NPs at 1,000 mg/L (99%), followed by CuO NPs at the same dose (95%). Fe2O3 NPs at all evaluated doses had no inhibitory effects on the mycelia growth of this strain, although F. oxysporum revealed greater effectiveness of the CuO NPs (96%) compared with ZnO NPs since it only inhibited 91% of the mycelial growth. The antibacterial activity was studied through optical density. C. michiganensis was found to be more sensitive to ZnO NPs because a lesser dose (700 mg/L) was required to reduce the bacterial growth (90%); in comparison, P. syringae required a dose of 1,000 mg/L to inhibit its growth (67%). CuO NPs displayed the smallest growth inhibition against the bacteria strains analysed. The antimicrobial effect of the metallic NPs that were assayed increased with higher doses.

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“…[144] Also potentially, the bactericidal property of this metal is relatively better than silver. [147] CuO nanoparticles, on the other hand, have shown to exhibit bactericidal response predominantly by ROS mediated pathways wherein the nanoparticles attached to the bacterial cells provoke the enhancement of the intracellular oxidative stress, which in-turn results in higher ROS leading to lipid peroxidation and irreversible cell damage. [145,146] The mechanism of bactericidal action of copper ions can happen in multiple ways.…”

Section: Nanomaterialsmentioning

confidence: 99%

“…The higher concentration of these species can lead to lipid peroxidation, protein oxidation, DNA degradation, and finally irreversible cell damage. [147] CuO nanoparticles, on the other hand, have shown to exhibit bactericidal response predominantly by ROS mediated pathways wherein the nanoparticles attached to the bacterial cells provoke the enhancement of the intracellular oxidative stress, which in-turn results in higher ROS leading to lipid peroxidation and irreversible cell damage. [17,148] Titania (TiO 2 ), Zinc Oxide (ZnO), Calcium Oxide (CaO), and Magnesium Oxide (MgO): TiO 2 is a photocatalyst and self-cleaning nanomaterial whose effect in the decontamination of water is widely investigated.…”

Section: Nanomaterialsmentioning

confidence: 99%

The Key Role of Modifications in Biointerfaces toward Rendering Antibacterial and Antifouling Properties in Polymeric Membranes for Water Remediation: A Critical Assessment

Samantaray

Madras

Bose

2019

Advanced Sustainable Systems

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Safe drinking water for all is a major challenge and needs critical attention, as freshwater aquifers are rapidly declining. A strategy based on addressing scarcity through membrane‐based purification and desalination can be an immediate and robust solution. The current scientific advances toward tailoring the structure and chemical properties of existing membrane materials have enabled key insights leading to new water purification alternatives. In the first part of the article, the key requirements for water decontamination addressed through state‐of‐the‐art literature on membranes are discussed. In the next part, the specific membrane modification strategies to impede bacterial growth and enhance fouling resistance are discussed, bringing in the underlying mechanisms. Finally, promising next‐generation separation techniques that are inspired by nature, inorganic and carbonaceous nanomaterial‐based membranes, layer‐by‐layer assembly, and dynamic composite membranes, are highlighted. This perspective article will help guide researchers working in this field from both industrial and academic standpoints, especially where the research is focused toward developing strategies to modify the existing solution besides finding alternative and sustainable new materials.

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Copper Nanoparticles as Antibacterial Agents

Cited by 115 publications

References 54 publications

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In vitro antimicrobial effect of metallic nanoparticles on phytopathogenic strains of crop plants

The Key Role of Modifications in Biointerfaces toward Rendering Antibacterial and Antifouling Properties in Polymeric Membranes for Water Remediation: A Critical Assessment

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