Copper oxide (CuO) and manganese oxide (MnO) nanoparticles induced biomass accumulation, antioxidants biosynthesis and abiotic elicitation of bioactive compounds in callus cultures of
            <i>Ocimum basilicum</i>
            (Thai basil)

Nazir, Saher; Jan, Hasnain; Zaman, Gouhar; Khan, Taimoor; Ashraf, Hajra; Meer, Bisma; Zia, Muhammad; Drouet, Samantha; Hano, Christophe; Abbasi, Bilal Haider

doi:10.1080/21691401.2021.1984935

Cited by 28 publications

(11 citation statements)

References 67 publications

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“…Cultivated plants with Cd- and Pb-contaminated soils showed a major influence on the EOs’ yield, composition, and phytoremediation of the soil ( Youssef, 2021 ). In addition, RA, chicoric acid, and eugenol were higher when cultured in CuO-NP media ( Nazir et al, 2021 ). Increase salicylic acid and its β-glucoside cause to accumulation of jasmonic and abscisic acids in O. basilicum due to foliar-spraying treatment with U. intestinalis extract and the essential oil (EO) chemotype changed from methyl eugenol/eugenol to epi-α-cadinol and increased sesquiterpenes ( Paulert et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

The Effect of Ocimum basilicum L. and Its Main Ingredients on Respiratory Disorders: An Experimental, Preclinical, and Clinical Review

2022

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Ocimum basilicum L. (O. basilicum) and its constituents show anti-inflammatory, immunomodulatory, and antioxidant effects. The plant has been mainly utilized in traditional medicine for the treatment of respiratory disorders. In the present article, effects of O. basilicum and its main constituents on respiratory disorders, assessed by experimental and clinical studies, were reviewed. Relevant studies were searched in PubMed, Science Direct, Medline, and Embase databases using relevant keywords including “Ocimum basilicum,” “basilicums,” “linalool,” “respiratory disease,” “asthma,” “obstructive pulmonary disease,” “bronchodilatory,” “bronchitis,” “lung cancer,” and “pulmonary fibrosis,” and other related keywords.The reviewed articles showed both relieving and preventing effects of the plant and its ingredients on obstructive pulmonary diseases such as chronic obstructive pulmonary disease (COPD), asthma, and other respiratory disorders such as bronchitis, aspergillosis tuberculosis, and lung cancer. The results of the reviewed articles suggest the therapeutic potential of O. basilicum and its constituent, linalool, on respiratory disorders.

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Section: Resultsmentioning

confidence: 99%

The Effect of Ocimum basilicum L. and Its Main Ingredients on Respiratory Disorders: An Experimental, Preclinical, and Clinical Review

2022

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“…In general, our findings are in accordance with the recent result reports. For example, a supplement of NPs to the plant media has increased phenolic compound production ( Jadczak et al, 2020 ; Nazir et al, 2021 ). The increase in phenols and flavonoids production may be due to ROS generation by NPs that starts complicated reactions and affects metabolic processes in the plant cells ( Hatami et al, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, induction factors are needed to enhance the productivity of phytochemical compounds from medicinal plants for nutritional and pharmaceutical purposes. Using NPs for bioactive component induction is one of the prioritized strategies for the sustainability of bioactive component production ( Tian et al, 2018 ; Vargas-Hernandez et al, 2020 ; Nazir et al, 2021 ). Therefore, the impact of biogenic AgNPs on bioactive compounds like coumarin, tannic acid, quercetin, rutin, gallic acid, and hesperidin production from callus was investigated.…”

Section: Resultsmentioning

confidence: 99%

“…In agreement with our findings, Chung et al (2018) reported that gallic acid, p -coumaric acid, o -coumaric acid, quercetin, rutin, and hesperidin were increased significantly in response to AgNPs treatment. In addition, a recent study discovered that CuO and MnO nanomaterials induced phytochemical compounds in the callus of Ocimum basilicum ( Nazir et al, 2021 ). The exposure of plants to NPs caused bioactive compound production reported by Marslin et al (2017) .…”

Section: Resultsmentioning

confidence: 99%

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Biogenic silver nanoparticles improve bioactive compounds in medicinal plant Juniperus procera in vitro

et al. 2022

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Bioactive compounds of medicinal plants present as natural ingredients provide health benefits beyond the basic nutritional value of these products. However, the availability of bioactive compounds in the current natural sources is limited. Hence, the induction of bioactive compound production from medicinal plants through nanoparticles (NPs) might play a vital role in industrially important medicinal compounds. Therefore, this study aimed to synthesize silver nanoparticles (AgNPs) biologically and to investigate their effect on phytochemical compound production from the callus of Juniperus procera. AgNPs were synthesized biologically using aqueous leaf extract of Phoenix dactylifera, which acted as a reducing and capping agent, and silver nitrate solution. The formation of AgNPs has been confirmed through different analytical techniques such as UV-Visible spectroscopy (UV), Fourier-transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), and scanning electron microscope (SEM). The impact of different concentrations (0.0, 5, 20, and 50 mg/L) of AgNPs on enzymatic and non-enzymatic antioxidants of the callus of J. procera was investigated. The obtained results showed a significant effect of AgNPs on biomass accumulation and non-enzymatic antioxidants (phenol, tannin, and flavonoid content). Additionally, total protein content and superoxide dismutase (SOD) activity were increased in response to AgNPs. Furthermore, bioactive compounds like gallic acid, tannic acid, coumarin, hesperidin, rutin, quercetin, and ferruginol were chromatographically separated and quantified using high-performance liquid chromatography (HPLC) with reference standards. These compounds were increased significantly in response to AgNPs treatments. We concluded that AgNPs could be a promising elicitor for improving the production of phytochemical compounds in medicinal plants. This work can serve asa good model for improving the production of bioactive compounds from medicinal plants in vitro. This molecular investigation should be done to understand better the metabolic mechanism leading to bioactive compound production scaling.

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“…They explored several plant growth regulators and found that 5 mg/L 6-benzylaminopurine (BAP) combined with 1 mg/L naphthalene acetic acid (NAA) yielded the best phenolic yield (346.08 mg/L), including 7.4 mg/g RA [ 28 ]. Subsequently, callus of basil grown on a medium supplemented with 10 mg/L CuO-NPs yielded the highest RA accumulation (11.4 mg/g) [ 29 ]. Light-emitting diode irradiation increased the RA content of callus 96.0 mg/g, 2.46-fold higher than control [ 30 ].…”

Section: Culture Techniques Extraction Processes and Anti-tumor Appli...mentioning

confidence: 99%

Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer

Zhao

Jin

et al. 2022

Biomolecules

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Cancer constitutes a severe threat to human health and quality of life and is one of the most significant causes of morbidity and mortality worldwide. Natural dietary products have drawn substantial attention in cancer treatment and prevention due to their availability and absence of toxicity. Rosmarinic acid (RA) is known for its excellent antioxidant properties and is safe and effective in preventing and inhibiting tumors. This review summarizes recent publications on culture techniques, extraction processes, and anti-tumor applications of RA-enriched dietary supplements. We discuss techniques to improve RA bioavailability and provide a mechanistic discussion of RA regarding tumor prevention, treatment, and adjuvant therapy. RA exhibits anticancer activity by regulating oxidative stress, chronic inflammation, cell cycle, apoptosis, and metastasis. These data suggest that daily use of RA-enriched dietary supplements can contribute to tumor prevention and treatment. RA has the potential for application in anti-tumor drug development.

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Copper oxide (CuO) and manganese oxide (MnO) nanoparticles induced biomass accumulation, antioxidants biosynthesis and abiotic elicitation of bioactive compounds in callus cultures of Ocimum basilicum (Thai basil)

Abstract: Copper oxide (CuO) and manganese oxide (MnO) nanoparticles induced biomass accumulation, antioxidants biosynthesis and abiotic elicitation of bioactive compounds in callus cultures of

Cited by 28 publications

References 67 publications

The Effect of Ocimum basilicum L. and Its Main Ingredients on Respiratory Disorders: An Experimental, Preclinical, and Clinical Review

The Effect of Ocimum basilicum L. and Its Main Ingredients on Respiratory Disorders: An Experimental, Preclinical, and Clinical Review

Biogenic silver nanoparticles improve bioactive compounds in medicinal plant Juniperus procera in vitro

Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer

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