Copper oxychloride–induced testicular damage of adult albino rats and the possible role of curcumin in healing the damage

El-Hak, Heba Nageh Gad; Mobarak, Yomn M.

doi:10.1007/s11356-020-07715-6

Cited by 12 publications

(5 citation statements)

References 68 publications

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“…In the presented work, corn oil treated rats didn't show any pathological alterations either in testicular tissues nor in serum sex hormones during all studies that were proceeded; this finding was in accordance with Gad El-Hak and Mobarak [75] , as they reported that corn oil didn't affect the normal histoarchitecture, testis weight, Sperm abnormality, serum Testosterone and LH hormones, and Testicular total antioxidants CONCLUSION GA caused a deleterious histological, morphometric, histochemical, immunohistochemical and biochemical alterations, with an impaired spermatogenesis and oxidative stress in testicular tissues. The findings of this study demonstrated that PDOE significantly ameliorated the reproductive toxicity induced by GA in rats which may be attributed to the antioxidant activities and free radical scavenging properties of PDOE.…”

Section: Discussionsupporting

confidence: 89%

Ameliorating Impact of Phoenix dactylifera L. Leaves Oil Extract on Testicular Toxicity Induced by Gibberellic Acid: Histomorphometric and Immunohistochemical Studies

Ahmed

Nofal²

2020

Egyptian Journal of Histology

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Background: Gibberellic acid is an endogenous plant growth regulator, it has many toxic effects including testicular toxicity. Phoenix dactylifera L. (date palm) is widely used in traditional medicine as anticancer, hepatoprotective, neuroprotective, nephroprotective, gastrointestinal protective and antimicrobial agent. Aim: The present work aimed to clarify the impact of Phoenix dactylifera L. leave oil extract on testicular toxicity induced by gibberellic acid in albino rats. Materials and Methods: Five groups of rats were used. Group1: control, Group 2: corn oil group, Group 3: Phoenix dactylifera L. leaves oil extract group , Group 4: Gibberellic acid group .Group 5 : Phoenix dactylifera L. leaves oil extract and Gibberellic acid group. Histomorphometric, Histochemical, immunohistochemical and biochemical alterations were investigated in testicular tissue and serum. Results: Gibberellic acid induced histopathological alterations, significantly decreased the Johnsen score of spermatogenesis, and significantly decreased the germ cell proliferation index (PI). , significantly decrease the epithelial height and tubular diameter and total glycogen content. Immuohistochemically, Gibberellic acid significantly decreased PCNA and GULT-3, while α-SMA was significantly increased. Gibberellic acid decreased serum testosterone, progesterone and LH hormones and testicular antioxidants, and significantly increased testicular MDA. Treating rats with both Phoenix dactylifera L. leaves oil extract and Gibberellic acid ameliorated all histopathological morphometric, histochemical, immunohistochemical and biochemical alterations induced by Gibberellic acid. Conclusion: Phoenix dactylifera L. leaves oil extract could ameliorate the histopathological and toxicological alterations induced by Gibberellic acid.

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Section: Discussionsupporting

confidence: 89%

Ameliorating Impact of Phoenix dactylifera L. Leaves Oil Extract on Testicular Toxicity Induced by Gibberellic Acid: Histomorphometric and Immunohistochemical Studies

Ahmed

Nofal²

2020

Egyptian Journal of Histology

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“…CUR decreases blood glucose as well as glycosylated hemoglobin levels and prohibited weight loss (Jain et al 2009 ). It was also suggested to decrease numerous other complications related to diabetes as fatty liver, diabetic neuropathy, diabetic nephropathy, vascular diseases, musculoskeletal diseases, and islet viability (Kunwar and Priyadarsini 2016 ; Gad El-Hak and Mobarak 2020 ). Due to its potential health advantages, researchers are paying great attention to CUR, a phytochemical found in the spice turmeric (Khorasani et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Comparative effects of curcumin versus nano-curcumin on histological, immunohistochemical expression, histomorphometric, and biochemical changes to pancreatic beta cells and lipid profile of streptozocin induced diabetes in male Sprague–Dawley rats

Metawea

Abdelrazek

El-Hak

et al. 2023

Environ Sci Pollut Res

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Diabetes mellitus is a worldwide problem characterized by hyperglycemia as well as the damage of the microscopic structure of the beta cells of Langerhans pancreatic islets. In the present study, the histological, immunohistochemical, morphometric, and biochemical alterations to pancreatic beta cells in streptozocin (STZ)-induced diabetes were assessed in rats treated with curcumin (CU) (100 mg/kg/day) or nano-curcumin (nCU) (100 mg/kg/day) for 1 month. Twenty-four adult male Wistar albino rats were distributed into four groups: the nondiabetic control group, the diabetic untreated group, and two diabetic groups treated with CU or nCUR, respectively. Blood glucose, serum insulin levels, and lipid profile were measured. The pancreatic tissues were collected and processed into paraffin sections for histological and immunohistochemical examination, oxidative stress markers, and real-time PCR expression for pancreatic and duodenal homeobox 1 (PDX1). The insulin expression in beta cells was assessed using immunohistochemistry. Morphometrically, the percentage area of anti-insulin antibody reaction and the percentage area of islet cells were determined. STZ-induced deteriorating alteration in beta cells led to declines in the number of functioning beta cells and insulin immunoreactivity. In STZ-treated rats, CU and nCUR significantly reduced blood glucose concentration while increasing blood insulin level. It also caused a significant increase in the number of immunoreactive beta cells to the insulin expression and significant reduction of the immunoreactive beta cells to the caspase-3 expression. In conclusion, CU and nCUR could have a therapeutic role in the biochemical and microscopic changes in pancreatic beta cells in diabetes-induced rats through STZ administration with more bio-efficacy of nCUR.

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“…Curcumin forms the basis of turmeric obtained from Curcuma longa rhizomes (Zingiberaceae family) (Joe, Vijaykumar, & Lokesh, 2004). Curcumin has been reported to increase testosterone and follicle‐stimulating hormone (FSH) levels and testicular total antioxidant levels in rats administered copper oxychloride (Gad El‐Hak & Mobarak, 2020). It has been reported that in rats administrated cyclophosphamide, it increases sperm count and motility and decreases abnormal sperm count.…”

Section: Introductionmentioning

confidence: 99%

Effects of curcumin on sperm quality, lipid profile, antioxidant activity and histopathological changes in streptozotocin‐induced diabetes in rats

et al. 2020

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In this study, the effect of low‐dose curcumin on sperm parameters, reproductive hormones, lipid profile, biochemical antioxidant parameters and the histopathological structure of the testis in diabetic male rats were evaluated. In the study, 28 male Wistar albino rats weighing 300–370 g and aged 8–10 weeks were used. Four groups of equal numbers have been created. Diabetes mellitus was induced with 45 mg/kg streptozotocin (STZ) in seven rats. Curcumin was administered to the rats in curcumin and the diabetes + curcumin group by gavage for 15 days at a dose of 10 mg/kg. Then, the rats were sacrificed. Blood samples and testis tissues were obtained, while the rats were under anaesthesia. Glucose, lipid profile, reproductive hormones, sperm parameters, biochemical antioxidant parameters and histopathological examination of the testis were performed. Abnormal sperm ratio, malondialdehyde, glucose, cholesterol, low‐density lipoprotein, and triglyceride levels and caspase‐3 expression were increased in diabetic rats, while the sperm motility and intensity and reduced glutathione, catalase and testosterone levels were decreased. When low‐dose curcumin (10 mg/kg) was administered to diabetic rats, we found that curcumin significantly increased sperm motility and density, and decreased abnormal sperm rate according to the diabetic group. Moreover, curcumin significantly suppressed the lipid profile and increased follicle‐stimulating hormone (FSH) and testosterone levels compared to the diabetic group. On testicular damage and decreased reproductive hormones caused by diabetes, curcumin may have a protective effect with indirect effect of glycaemic control by curcumin.

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Copper oxychloride–induced testicular damage of adult albino rats and the possible role of curcumin in healing the damage

Cited by 12 publications

References 68 publications

Ameliorating Impact of Phoenix dactylifera L. Leaves Oil Extract on Testicular Toxicity Induced by Gibberellic Acid: Histomorphometric and Immunohistochemical Studies

Ameliorating Impact of Phoenix dactylifera L. Leaves Oil Extract on Testicular Toxicity Induced by Gibberellic Acid: Histomorphometric and Immunohistochemical Studies

Comparative effects of curcumin versus nano-curcumin on histological, immunohistochemical expression, histomorphometric, and biochemical changes to pancreatic beta cells and lipid profile of streptozocin induced diabetes in male Sprague–Dawley rats

Effects of curcumin on sperm quality, lipid profile, antioxidant activity and histopathological changes in streptozotocin‐induced diabetes in rats

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