Copper pyrazole complexes as potential anticancer agents: Evaluation of cytotoxic response against cancer cells and their mechanistic action at the molecular level

Synthesis and Characterization of New Bases Derived from Nitrophenylpyrazoles, Coordination to Palladium and Antifungal Activity and Catalytic Activity in Mizoroki–Heck Reactions

“…The pyrazole scaffold is present in a plethora of biologically relevant molecules that show a wide variety of pharmaceutical and biological properties, including antifungal, anticancer, antiviral, anti-inflammatory, antioxidant and other activities [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. This scaffold is also useful as a synthetic building block and in coordination chemistry [20][21][22][23][24][25][26][27][28][29][30][31][32]. Hence, considerable efforts have been made in the synthesis of new pyrazole-based complex structures and in the development of new methods for their construction [33][34][35][36].…”

Mononuclear copper(ii) complexes with polypyridyl ligands: synthesis, characterization, DNA interactions/cleavages and in vitro cytotoxicity towards human cancer cells

“…Being one of the essential metals, copper has widespread applications not only in redox chemistry but also in the field of chemotherapeutic drug discovery. 5–10 The structural variation in the metal center provides the required steric properties, and the well-established coordination chemistry has provided thorough insights into its potential use as a promising replacement. Furthermore, the antibacterial, antifungal, antiviral, cytotoxic and DNA binding/cleaving activities have been studied.…”

Selected Electrosynthesis of 3-Aminopyrazoles from α,β-Alkynic Hydrazones and Secondary Amines

“…Pyrazoles are an important class of nitrogen-containing heterocycles, exhibiting a wide range of pharmacological and biological properties . As a result, a significant amount of research had been devoted to the synthesis of the pyrazole core moiety, and typical synthetic approaches for functionalized pyrazoles involved the cycloaddition of α,β-alkynic hydrazones.…”