Copper(<scp>ii</scp>) complexes of sterically hindered phenolic Schiff bases: synthesis, characterization, interaction with biomolecules, and antioxidant and antimicrobial activity

Turomsha, Iveta S.; Gvozdev, Maxim Y.; Osipovich, Nikolai P.; Staravoitava, Viktoryia A.; Shiman, Dmitriy I.; Loginova, Natalia V.

doi:10.1039/d4nj00430b

New J. Chem.

2024

DOI: 10.1039/d4nj00430b

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Copper(ii) complexes of sterically hindered phenolic Schiff bases: synthesis, characterization, interaction with biomolecules, and antioxidant and antimicrobial activity

Iveta S. Turomsha,

Maxim Y. Gvozdev,

Nikolai P. Osipovich

et al.

Abstract: Phenolic Schiff bases and their Cu(ii) complexes have been synthesized and characterized by physicochemical methods. The complexes exhibit low cell toxicity and high antioxidant and antibacterial activity, as evidenced by molecular docking studies.

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Cited by 2 publications

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Syntheses, characterization and antibacterial activity of mononuclear and dinuclear copper(II) complexes containing a hydrazone ligand

Sun,

Wen,

Kan

et al. 2024

Journal of Coordination Chemistry

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Syntheses, characterization and antibacterial activity of mononuclear and dinuclear copper(II) complexes containing a hydrazone ligand

Sun,

Wen,

Kan

et al. 2024

Journal of Coordination Chemistry

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Antituberculosis, antimicrobial, antioxidant, cytotoxicity and anti-inflammatory activity of Schiff base derived from 2,3-diaminophenazine moiety and its metal(II) complexes: structural elucidation, computational aspects, and biological evaluation

Bufarwa,

El-Sefait,

Thbayh

et al. 2024

Reviews in Inorganic Chemistry

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Enticed by the present scenario of infectious diseases, four new Co(II), Ni(II), Cu(II), and Cd(II) complexes of Schiff base ligand were synthesized from 6,6′-((1E-1′E)(phenazine-2,3-dielbis(azanylidene)-bis-(methanylidene)-bis-(3-(diethylamino)phenol)) (H 2 L) to ascertain as effective drug for antituberculosis, anti-inflammatory, antioxidant, cytotoxic and antimicrobial activities. The organic ligand and its metal(II) complexes were characterized by numerous physical and spectroscopic methods, which showed that the complexes have a general formula, [ML], (where M = Co(II) (C1), Ni(II) (C2), Cu(II) (C3) and Cd(II) (C4)), for metal complexes have been proposed and have a square planar geometry, are amorphous in nature, and are thermally stable. Data highlight obtained from activity testing against tuberculosis, inflammation, and oxidants that all compounds are significantly active against these symptoms. Also, was to evaluate the effectiveness of various compounds against bacterial and fungal strains. Specifically, four bacterial strains (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa) and two fungal strains (Aspergillus flavus and Candida albicans) were tested and compared to the results of some standard drugs. The results revealed that compound C4 was more effective against bacterial strains than the comparison standard drugs. In addition, C3 was found to be the most effective of the comparison antibiotics against fungi, while the other compounds showed moderate antifungal activity. Moreover, to support the vitro results, certain computational studies as molecular docking studies, DFT, MESP, and AMEDT were also conducted to confirm the effectiveness of an organic ligand and its complexes against tuberculosis. These studies revealed that C4 is the most effective against tuberculosis and has desirable effects such as absorption, no degradation and no hepatotoxicity, etc.

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Copper(ii) complexes of sterically hindered phenolic Schiff bases: synthesis, characterization, interaction with biomolecules, and antioxidant and antimicrobial activity

Abstract: Phenolic Schiff bases and their Cu(ii) complexes have been synthesized and characterized by physicochemical methods. The complexes exhibit low cell toxicity and high antioxidant and antibacterial activity, as evidenced by molecular docking studies.

Cited by 2 publications

References 84 publications

Syntheses, characterization and antibacterial activity of mononuclear and dinuclear copper(II) complexes containing a hydrazone ligand

Syntheses, characterization and antibacterial activity of mononuclear and dinuclear copper(II) complexes containing a hydrazone ligand

Antituberculosis, antimicrobial, antioxidant, cytotoxicity and anti-inflammatory activity of Schiff base derived from 2,3-diaminophenazine moiety and its metal(II) complexes: structural elucidation, computational aspects, and biological evaluation

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