Copper Transport in Mammals

Linder, Maria C.; Lomeli, Norma A.; Donley, Stephanie; Mehrbod, Farrokh; Cerveza, Philip; Cotton, Stephen J.; Wooten, Lisa

doi:10.1007/978-1-4615-4859-1_1

Cited by 43 publications

(32 citation statements)

References 33 publications

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“…68,69 Cu-64 isotope experiments have indicated that most of the Cu bound to ceruloplasmin is not exchangeable, and minor amounts of Cu bound to albumin are exchangeable with low-molecular weight Cu carriers, such as amino acids (AAs). The resultant binary Cu-histidine and ternary Cu-histidine-AA (AA: aspargine, glutamine, serine, or threonine) complexes are considered important as Cu carriers through membranes [70][71][72] (This coincides with the computer simulation shown in clarified the relationships between Cu transport and genetic disorders such as Menkes disease.…”

Section: Transport Of Cumentioning

confidence: 99%

Demonstration of the Importance of Metal Ion Speciation in Bioactive Systems

Kiss¹,

Odani²

2007

Bulletin of the Chemical Society of Japan

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This paper gives insight into chemical speciation. After a brief introduction, the methods available to study solution state of metal ions and the importance of speciation in biology are discussed through different examples. Speciation of toxic Al III , beneficial Cu II and Ca II and potentially medicinal Pd II and VO IV in various biofluids and tissues is discussed in order to describe the solution state of these metal ions in an organism. The relevance of ternary complex formation with endogenous biomolecules is emphasised. The importance of the biospeciation of Al III ion in its transport and involvement in neurological disorders, of the actual chemical form of the insulin-mimetic VO IV complexes in its biological occurrence and Ca II in mineralization/demineralization processes is discussed. The role of time, i.e., the kinetic aspects of biospeciation, is discussed in the case of the transport of Al III and Cu II and some Pd II complexes (models of the anticancer Pt II complexes) in blood serum.

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Section: Transport Of Cumentioning

confidence: 99%

Demonstration of the Importance of Metal Ion Speciation in Bioactive Systems

Kiss¹,

Odani²

2007

Bulletin of the Chemical Society of Japan

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“…Like iron, copper is an essential nutrient for most organisms and can assume two oxidation states, Cu + and Cu +2 , that participate in redox reactions (Linder et al, 1999). In mammals, two multicopper oxidases, Heph and ceruloplasmin (CP) catalyze the oxidation of Fe +2 to Fe +3 (Mukhopadhyay et al, 1998).…”

Section: A Comparison Of the Multi-copper Oxidases Involved In Iron Mmentioning

confidence: 99%

Iron metabolism in insect disease vectors: Mining the Anopheles gambiae translated protein database

Winzerling

Pham

2006

Insect Biochemistry and Molecular Biology

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“…Cu transport in the blood has been studied extensively [219,220], where 64 Cu isotope experiments have shown that most of the Cu bound to ceruloplasmin is not exchangeable, whereas that bound to HSA is exchangeable with LMM Cu carriers, such as AAs. The resulting complexes formed with AAs are considered important as Cu carriers through membranes (Eq.…”

Section: Transport Of Cu(ii) From Complexes With His-containing Peptimentioning

confidence: 99%