Copper‐Zinc Bimetallic Single‐Atom Catalysts with Localized Surface Plasmon Resonance‐Enhanced Photothermal Effect and Catalytic Activity for Melanoma Treatment and Wound‐Healing

Abstract

Nanomaterials with photothermal combined chemodynamic therapy (PTT-CDT) have attracted the attention of researchers owing to their excellent synergistic therapeutic effects on tumors. Thus, the preparation of multifunctional materials with higher photothermal conversion efficiency and catalytic activity can achieve better synergistic therapeutic effects for melanoma. In this study, a Cu-Zn bimetallic single-atom (Cu/PMCS) is constructed with augmented photothermal effect and catalytic activity due to the localized surface plasmon resonance (LSPR) effect. Density functional theory calculations confirmed that the enhanced photothermal effect of Cu/PMCS is due to the appearance of a new d-orbital transition with strong spin-orbit coupling and the induced LSPR. Additionally, Cu/PMCS exhibited increased catalytic activity in the Fenton-like reaction and glutathione depletion capacity, further enhanced by increased temperature and LSPR. Consequently, Cu/PMCS induced better synergistic anti-melanoma effects via PTT-CDT than PMCS in vitro and in vivo. Furthermore, compared with PMCS, Cu/PMCS killed bacteria more quickly and effectively, thus facilitating wound healing owing to the enhanced photothermal effect and slow release of Cu 2+ . Cu/PMCS promoted cell migration and angiogenesis and upregulated the expression of related genes to accelerate wound healing. Cu/PMCS has potential applications in treating melanoma and repairing wounds with its antitumor, antibacterial, and wound-healing properties.

Recent Progress of Studies on Photoconversion and Photothermal Conversion of CO2 with Single-Atom Catalysts

“…At present, the photothermal effect has been widely used in pollutant removal, desalination, and cancer treatment. Therefore, single-atom catalysts, especially single-atom catalysts (SACs) prepared with photothermal effect substrates, can overcome many problems of traditional photothermal catalysts, maximize the utilization rate of catalytic active sites and material stability, and show a good prospect of SACs for photothermal catalysis. , …”

Sustained Releasable Copper and Zinc Biogenic Ions Co-Assembled in Metal–Organic Frameworks Reinforced Bacterial Eradication and Wound Mitigation in Diabetic Mice

“…2 Particularly, the copper and zinc ions are the most identified essential elements to promote wound healing through various factors, including angiogenesis, antioxidation, collagen deposition, and stimulation. 3,4 Copper and zinc are biogenic elements that involve several important pathways in mammalian life. 5−7 Zinc is the most required cofactor for various metallozymes needed for cell proliferation, cell membrane repair, cell growth, and the functioning of an immune system.…”

“…Metal ions have special effects in maintaining the ordinary processes of the human body and metabolism and aid in tissue repair . Particularly, the copper and zinc ions are the most identified essential elements to promote wound healing through various factors, including angiogenesis, antioxidation, collagen deposition, and stimulation. , Copper and zinc are biogenic elements that involve several important pathways in mammalian life. − Zinc is the most required cofactor for various metallozymes needed for cell proliferation, cell membrane repair, cell growth, and the functioning of an immune system . Copper essentially participates in several stages of the wound healing process and plays an important role in various cells by modulating various cytokines and growth factor mechanisms of action .…”

Dynamically modulating the mid-infrared localized surface plasmon resonance of Al-doped ZnO nanocrystals

“…The localized surface plasmon resonance (LSPR) of metal nanoparticles has been used in biomedical applications, sensors, catalysis, and surface-enhanced spectroscopy [1][2][3][4][5]. Unlike metal nanoparticles, the LSPR of doped semiconductor nanocrystals (NCs) can be modulated by changing the doping content.…”