Copro‐antibody in Calves from Dams Vaccinated against Salmonella typhimurium

Abstract

Summary Calves received colostrum either with (positive colostrum) or without (negative colostrum) anti‐Salmonella typhimurium antibodies. Regarding the detectability of copro‐antibodies, the following observations have been made. In calves that had been given positive colostrum on day 4 post natum (p.n.), copro‐antibodies were detectable over 7 days, while in those that had received positive colostrum on day 1 p.n. copro‐antibodies were detectable over 45 days. After supplying highly positive colostrum, copro‐antibodies were found over a period of 8 weeks, and after supplying weakly positive colostrum, they were found over a period of 5 weeks. It is concluded that serum antibodies are transferred to the intestine for maximum local protection, and that there exists a preference for the intestinal system regarding the distribution of salmonella antibodies. Challenge infection on day 5 p.n. of calves that had received highly positive colostrum resulted in a copro‐antibody gap that reached the limit of detectability in two calves that were excreting salmonellas. Challenge infection of calves that had received negative colostrum provoked a local IgM and IgA antibody response.

Vaccination of pregnant guinea pigs with aromatic dependent Salmonella typhimurium to protect their newborns

“…These results were relied upon to protect newborns in early stage of life (4,15). Vaccinated group of pregnant G.pigs showed a marked level of cell-mediated immunity, through determination of positive DTH skin reaction, this results in agreement with other studies (7,14).…”

“…The most frequently used serological test for salmonllosis is tube agglutination test, this test is carried out with somatic and flagellar antigen (4). Vaccinated pregnant G.pigs revealed elevated levels of O and H antibody titers, and the maximum elevation was noticed after the booster dose, this is in agreement with the results reported previously (14). Detection of the O and H antibody titers in the newborns may indicate passive transfer of immunity from the vaccinated dams.…”