Copulation activates Fos-like immunoreactivity in the male quail forebrain

Meddle, Simone; King, Vicky; Follett, B. K.; Wingfield, John C.; Ramenofsky, Marilyn; Foidart, Agnès; Balthazart, Jacques

doi:10.1016/s0166-4328(97)87581-x

Cited by 81 publications

(110 citation statements)

References 65 publications

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“…Furthermore the size of the ARO-ir neurons is increased by testosterone more in the caudo-lateral as compared to the caudo-medial POM, suggesting that testosterone is acting in a more prominent manner particularly in this subregion of the nucleus POM [12]. Finally, as already mentioned, immunocytochemical studies indicate that the induction of the FOS protein following expression of male copulatory behavior is more pronounced in the caudal than in the rostral part of the POM [93].…”

Section: Neurochemical and Hodological Heterogeneity Of The Medial Prsupporting

confidence: 53%

“…This caudal part of the POM is also the region of the dimorphic nucleus where electrolytic lesions and destruction of ARO-ir cells induce the most marked behavioral deficits (see [23] for detail of these analyses). This same caudal part of the POM is also the region of the nucleus where the largest number of c-fos-immunoreactive cells is observed in birds that were allowed to express copulatory behavior before brain collection [93]. Lesion studies, testosterone implant experiments and investigations of c-fos expression thus all converge to indicate that the caudal part of the POM, just rostral to the anterior commissure, is critically implicated in the activation of male copulatory behavior.…”

Section: The Quail Pom As a Model System Illustrating The Effects Of mentioning

confidence: 89%

“…Conversely, a large number of studies in a variety of species indicate that stereotaxic implants of testosterone in the mPOA activate most if not all aspects of male copulatory behavior [32,80]. The implication of the mPOA in the control of male sexual behavior is also attested by experiments demonstrating that performance of this behavior increases neuronal activity in this brain region as assessed by an increase in 2-deoxyglucose incorporation [60], cytochrome oxidase activity [122] or increased transcription of immediate early genes such as c-fos or egr-1 (also know as Zenk in the avian literature) [49,56,76,93,118,134,153].…”

Section: The Preoptic Area As An Integration Center For the Control Omentioning

confidence: 95%

“…One must recall, however, that in quail, the caudal POM expresses a higher number of aromataseimmunoreactive cells than its rostral part [27], that these caudal cells are more affected by testosterone [27], that following expression of copulatory behavior more FOSexpressing cells are found in the caudal than in the rostral POM [93] and finally that the sex difference affecting the number of aromatase-immunoreactive of the POM projecting to the PAG is more prominent in the caudal part of the nucleus [48].…”

Section: Anatomical Studiesmentioning

confidence: 99%

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Topography in the preoptic region: Differential regulation of appetitive and consummatory male sexual behaviors

Balthazart

Ball

2007

Frontiers in Neuroendocrinology

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168

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Several studies have suggested dissociations between neural circuits underlying the expression of appetitive (i.e. sexual motivation) and consummatory components (i.e., copulatory behavior) of vertebrate male sexual behavior. The medial preoptic area (mPOA) clearly controls the expression of male copulation but, according to a number of experiments, is not necessarily implicated in the expression of appetitive sexual behavior. In rats for example, lesions to the mPOA eliminate maletypical copulatory behavior but have more subtle or no obvious effects on measures of sexual motivation. Rats with such lesions still pursue and attempt to mount females. They also acquire and perform learned instrumental responses to gain access to females. However, recent lesions studies and measures of the expression of the immediate early gene c-fos demonstrate that, in quail, subregions of the mPOA, in particular of its sexually dimorphic component the medial preoptic nucleus, can be specifically linked with either the expression of appetitive or consummatory sexual behavior. In particular more rostral regions can be linked to appetitive components while more caudal regions are involved in consummatory behavior. This functional sub-region variation is associated with neurochemical and hodological specializations (i.e. differences in chemical phenotype of the cells or in their connectivity), especially those related to the actions of androgens in relation to the activation of male sexual behavior, that are also present in rodents and other species. It could thus reflect general principles about POA organization and function in the vertebrate brain.

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Section: Neurochemical and Hodological Heterogeneity Of The Medial Prsupporting

confidence: 53%

Section: The Quail Pom As a Model System Illustrating The Effects Of mentioning

confidence: 89%

Section: The Preoptic Area As An Integration Center For the Control Omentioning

confidence: 95%

Section: Anatomical Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Topography in the preoptic region: Differential regulation of appetitive and consummatory male sexual behaviors

Balthazart

Ball

2007

Frontiers in Neuroendocrinology

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193

168

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“…25,36,74,90,93 Interestingly, the homologous structures also express Fos in quail after copulation despite the facts that these birds are supposed to depend only marginally on olfactory stimuli during sexual interactions and that they are devoid of an intromittent organ so that somatosensory stimuli originating from the genital area should be quite different from what they are in mammals. 66 In addition, Fos expression is observed in the hyperstriatum ventrale and nucleus intercollicularis (a vocal control area) of the quail brain after copulation, 66 indicating that these regions also participate either in the activation of behavior or in the processing of stimuli encountered in these conditions. A similar pattern of brain activation has also been observed by the study of the immediate early gene, Zenk in copulating quail.…”

mentioning

confidence: 99%

Performance of appetitive or consummatory components of male sexual behavior is mediated by different brain areas: a 2-deoxyglucose autoradiographic study

Dermon¹,

Stamatakis²,

Tlemçani³

et al. 1999

Neuroscience

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Abstract-The in vivo autoradiographic deoxyglucose method was used to identify the functional brain circuits that are involved in the performance of appetitive and consummatory components of male sexual behavior in Japanese quail (Coturnix japonica). Two groups of castrated, testosterone-treated male quail were trained during 12 sessions to associate the view of a female behind a window with the opportunity to interact freely and to copulate with her. They developed, as a consequence, a social proximity response (staying close and looking through the window providing a view of the female) that has been used in previous experiments to measure appetitive sexual behavior. A third control group (also castrated and treated with testosterone) was allowed to view the female but not to copulate with her and therefore did not develop this proximity response. 2-14 C-deoxyglucose was then injected i.p. to these birds and they were allowed to either copulate freely with a female (consummatory sexual behavior group) or express the social proximity response (appetitive sexual behavior group). The control group was provided a view of the female but these birds, although they were exposed to the same stimuli as birds in the appetitive group, did not express the social proximity response because they had never learned the association with the opportunity to copulate. Birds were killed 45 min after the deoxyglucose injection and their brains were processed for autoradiography. Densitometric analyses of the autoradiograms revealed that the expression of appetitive or consummatory aspects of male sexual behavior was associated with significant increases by comparison with the control group in the deoxyglucose incorporation in the nucleus mesencephalicus lateralis, pars dorsalis and in the nucleus leminsci lateralis. In addition, an increase in the deoxyglucose incorporation was specifically observed in the paleostriatum primitivum, rostral preoptic area, nucleus intercollicularis, nucleus interpeduncularis and third nerve but a decrease was observed in the dorsomedial part of the hippocampus and in the nucleus nervi oculomotori in birds of the consummatory sexual behavior group by comparison with controls. By contrast, in the appetitive sexual behavior group, significant increases in deoxyglucose incorporation were observed in two telencephalic areas, the intermediate hyperstriatum ventrale and neostriatum caudolaterale by comparison with the controls, but decreases were detected in the stratum griseum et fibrosum superficiale of optic tectum by comparison with the consummatory behavior group.These studies demonstrate that the performance of appetitive or consummatory components of male sexual behavior affects in a specific manner the deoxyglucose uptake and accumulation in specific regions of the quail brain. Changes in metabolic activity were observed in steroid-sensitive areas, in auditory, visual and vocal brain regions, and in brain nuclei related to motor behavior but also in association telencephalic and limbic structures. T...

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Organizational effects of estrogens on brain vasotocin and sexual behavior in quail

et al. 1998

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Reproductive behavior is sexually differentiated in quail: The male‐typical copulatory behavior is never observed in females even after treatment with high doses of testosterone (T). This sex difference in behavioral responsiveness to T is organized during the embryonic period by the exposure of female embryo to estrogens. We showed recently that the sexually dimorphic medial preoptic nucleus (POM), a structure that plays a key role in the activation of male copulatory behavior, is innervated by a dense steroid‐sensitive network of vasotocin‐immunoreactive (VT‐ir) fibers in male quail. This innervation is almost completely absent in the female POM and is not induced by a chronic treatment with T, suggesting that this neurochemical difference could be organizational in nature. This idea was tested by injecting fertilized quail eggs of both sexes on day 9 of incubation with either estradiol benzoate (EB) (25 μg, a treatment that suppresses the capacity to show copulatory behavior in adulthood) or the aromatase inhibitor R76713 (10 μg, a treatment that makes adult females behaviorally responsive to T), or with the solvents as a control (C). At 3 weeks posthatch, all subjects were gonadectomized and later implanted with Silastic capsules filled with T. Two weeks later, all birds were perfused and brain sections were processed for VT immunocytochemistry. Despite the similarity of the adult endocrine conditions of the subjects (all were gonadectomized and treated with T Silastic implants providing the same plasma level of steroid to all subjects), major qualitative differences were observed in the density of VT‐ir structures in the POM of the different groups. Dense immunoreactive structures (fibers and a few cells) were observed in the POM of C males but not females; EB males had completely lost this immunoreactivity (and lost the capacity to display copulatory behavior); and, conversely, R76713 females displayed a male‐typical VT‐ir system in the nucleus (and also high levels of copulatory behavior). Similar changes in immunoreactivity were seen in the nucleus of the stria terminalis and in the lateral septum (VT‐ir fibers only in this case) but not in the magnocellular vasotocinergic system. These neurochemical changes closely parallel the effects of the embryonic treatments on male copulatory behavior. The vasotocinergic system of the POM can therefore be considered an accurate marker of the sexual differentiation of brain circuits mediating this behavior. © 1998 John Wiley & Sons, Inc. J Neurobiol 37: 684–699, 1998

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Copulation activates Fos-like immunoreactivity in the male quail forebrain

Cited by 81 publications

References 65 publications

Topography in the preoptic region: Differential regulation of appetitive and consummatory male sexual behaviors

Topography in the preoptic region: Differential regulation of appetitive and consummatory male sexual behaviors

Performance of appetitive or consummatory components of male sexual behavior is mediated by different brain areas: a 2-deoxyglucose autoradiographic study

Organizational effects of estrogens on brain vasotocin and sexual behavior in quail

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