Copy number of latent viruses, oncogenicity, and the microcompetition model

Polansky, Hanan; Schwab, Hava

doi:10.18632/oncotarget.25804

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Viruses Reduce Available Gabp Via Microcompetition1

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2018

2023

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Cited by 5 publications

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“…After establishing a latent infection, the viral N-boxes bind and sequester the cellular GABP•p300/CBP transcription complex. Since the p300/CBP coactivator is limiting [33][34][35][36][37], the GABP•p300/CBP transcription complex is limiting. As a result, the sequestering of the complex by the viral promoter/ enhancer decreases the binding of GABP•p300/CBP to cellular genes, specifically, to the BRCA1 gene.…”

Section: Viruses Reduce Available Gabp Via Microcompetitionmentioning

confidence: 99%

How latent viruses cause breast cancer: An explanation based on the microcompetition model

Polansky

Schwab

2018

Bosn J of Basic Med Sci

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Most breast cancer cases show a decrease in the concentration of the breast cancer type 1 susceptibility protein (BRCA1). However, only a small portion of these cases have a mutated BRCA1 gene. Although many attempts have been made to identify the reason for the decrease in BRCA1 concentration in sporadic, non-heritable breast cancer cases, the cause is still unknown. In this review, we use the Microcompetition Model to explain how certain latent viruses, which are frequently detected in breast cancer tumors, can decrease the expression of the BRCA1 gene and cause the development of breast tumors.

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