Coral Hydrate, a Novel Antioxidant, Improves Alcohol Intoxication in Mice

Abstract

Alcohol-drinking culture may cause individuals to periodically experience unpleasant hangovers. In addition, ethanol catabolism stimulates the production of free radicals that may cause liver injury and further lead to the development of chronic alcoholic fatty liver disease. Although a number of studies have suggested that hydrogenated water may be consumed to act as free radical scavenger, its instability limits its application. In this study, we used coral hydrate (i.e., hydrogenated coral materials) as a more stable hydrogen source and evaluated its effects in a murine model of alcohol intoxication. In solution, coral hydrate exhibited much more stable redox potential than did hydrogenated water. Furthermore, administration of coral hydrate by oral gavage significantly prolonged the time to fall asleep and decreased the total sleep time in mice that received intraperitoneal injection of ethanol. The mice receiving coral hydrate also had lower plasma ethanol and acetaldehyde levels than controls. In line with this observation, hepatic expression of alcohol dehydrogenase, acetaldehyde dehydrogenase, catalase and glutathione peroxidase were all significantly increased by the treatment. Meanwhile, alcohol-induced upregulation of pro-inflammatory factors was attenuated by the administration of coral hydrate. Taken together, our data suggest that coral hydrate might be an effective novel treatment for alcohol intoxication.

Hydrogen therapy: recent advances and emerging materials

“…135 To achieve sustained hydrogen generation for prolonged therapeutic effects, Wu's team further modified the porous coral materials into coral hydrate, demonstrating sustained redox potential for at least 24 hours, significantly longer compared to conventional methods like hydrogenated water. 136 CaH 2 has also been identified as a potent anticancer agent, with the generated H 2 capable of modifying the TME and the calcium inducing cancer cell apoptosis. 137 Iron: Unlike other hydrogen-generating metallic materials, iron requires acid to efficiently generate hydrogen: Fe + 2H + → Fe 2+ + H 2 .…”

A Novel Antioxidant, Hydrogen-Rich Coral Calcium Alters Gut Microbiome and Bile Acid Synthesis to Improve Methionine-and-Choline-Deficient Diet-Induced Non-Alcoholic Fatty Liver Disease

“…By immobilizing hydrogen on the surface of coral calcium, HRCC can be created, providing a safer and more convenient method of hydrogen delivery [ 28 ]. Although it is known that HRCC exerts a stable antioxidative capacity and shows improvement of alcoholic intoxication and impaired liver function [ 29 ], the effects of HRCC on NAFLD are still unknown.…”