Corchorusin-D, a saikosaponin-like compound isolated from Corchorus acutangulus Lam., targets mitochondrial apoptotic pathways in leukemic cell lines (HL-60 and U937)

Abstract

COR-D possesses significant anti-leukemic activity in U937 and HL-60 cell lines by acting on the mitochondrial apoptotic pathways. Since the necrotic body formation is low after COR-D treatment, the occurrence of inflammation in in vivo systems could be reduced, which represents a positive indication in view of therapeutic application.

Saikosaponin D disrupts platelet-derived growth factor-β receptor/p38 pathway leading to mitochondrial apoptosis in human LO2 hepatocyte cells: A potential mechanism of hepatotoxicity

“…These results were also in line with other reports showing that SSD inhibited cell proliferation and induced apoptosis by modulating Bcl-2 family proteins in HepG2 and Hep3B cells [22], and in lymphocytes [23]. SSD was also shown to result in apoptotic cell death by inciting the release of apoptosis-inducing factor from mitochondria, which resulted in the subsequent accumulation of cells in the sub-G0 phase followed by DNA fragmentation in leukemic cell lines U937 and HL-60 [36]. Whether this caspase-independent apoptosis exists in SSD-induced hepatocyte apoptosis needs further explorations.…”

Arsenic trioxide-mediated growth inhibition of myeloma cells is associated with an extrinsic or intrinsic signaling pathway through activation of TRAIL or TRAIL receptor 2

“…[15][16][17] Along with upregulations of Bax and caspase 9 and downregulations of Bcl-xL, this apoptotic pathway is considered intrinsic. 35 However in this study, Bax, caspase 9 and Bcl-xL protein levels in myeloma cells with mutant p53 remained unchanged after ATO treatment in most of the cell lines. Caspase 8 activation is considered unique to the extrinsic apoptotic pathway while caspase 3 is considered to be the silenced, caspase 8 expression increased.…”

Corchorus olitorius(jute) extract induced cytotoxicity and genotoxicity on human multiple myeloma cells (ARH-77)

“…Saikosaponins and saikosaponin-like compounds have been reported to possess potent antitumor activity (Bachran et al, 2008). In a study of Mallick et al (2010), methanol extract of Corchorus acutangulus, its n-butanol fraction, and corchorusin-D inhibited cell growth and produced significant cytotoxicity in leukemic cell lines U937 and HL-60 via mitochondrial apoptotic pathway.…”