Cord blood 25(OH)D3, cord blood total immunoglobulin E levels, and food allergies in infancy: A birth cohort study in Chongqing, China

Wang, Nianrong; Liu, Shijian; Xiao, Guiyuan; Zhang, Hua; Huang, Yujie; Wang, Li; He, Chunyan

doi:10.1016/j.waojou.2022.100645

Cited by 5 publications

(8 citation statements)

References 45 publications

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“…The included papers were based on 33 separate study populations, including six RCTs (eight papers 33,43,50‐55 ), 25 longitudinal cohorts (33 papers 17,34,35‐37,39‐41,44,56‐79 ) and two case–cohort studies 80,81 . Two RCTs (Project VDAART 53,54 and Rueter et al's studies 50,51 ) and seven prospective studies generated multiple publications.…”

Section: Resultsmentioning

confidence: 99%

“… c One study used dried spotted sample which was taken at the first 48–72 h after birth 80 . Two studies 77,78 are from the same cohort and reported association using different vitamin D sufficiency threshold. We chose the one 77 used 20 ng/mL as the threshold to pool the estimate. …”

Section: Resultsmentioning

confidence: 99%

“…Food allergy : Associations between vitamin D levels and food allergy outcomes were reported in 12 observational studies 17,35,41,63,67,70,75‐78,80,81 . The association between vitamin D dietary intake and food allergy was reported only in three studies 39,75,79 .…”

Section: Resultsmentioning

confidence: 99%

“…17 ,35,41,63,67,70,75-78,80,81 The association between vitamin D dietary intake and food allergy was reported only in three studies. 39,75,79 Studies used several food allergy assessment methods, including SPT and oral food challenge up to 2 years old, 63,77,78,81 SPT and food allergy history report at 1 year 75 and 3 years old 17 and 9 years old, 35 SPT and peanut allergy under 6 years old, 80 the doctor diagnosed cow milk allergy up to 3 years old, 39 parental report of food allergy symptoms and IgE level testing at 1 year old, 70 and parental report of doctor diagnosis from 1 to 9 years old 41,76,79 (Table S3).…”

Section: Outcome Assessmentmentioning

confidence: 99%

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Is antenatal or early‐life vitamin D associated with eczema or food allergy in childhood? A systematic review

Zeng

Shen

et al. 2023

Clin Experimental Allergy

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Objective To summarise the associations between antenatal or early‐life blood vitamin D and the development of eczema/food allergy in childhood. Design A systematic review and meta‐analyses were conducted to synthesize the published literature. Two reviewers independently performed the study selection and data extraction on Covidence. We assessed the risk of bias for observational studies by using the Newcastle‐Ottawa Scale and the Cochrane Risk of Bias tool for clinical trials. The certainty of the evidence was assessed using Grading of Recommendations, Assessment, Development and Evaluations (GRADE). Data sources We systematically searched PubMed and Embase from inception and April 2022. Eligibility criteria Human studies that investigated prospective associations between antenatal or early‐life blood vitamin D levels, dietary intake or supplementation and childhood eczema/food allergy. Results Forty‐three articles including six randomised controlled trials (RCTs) were included. Four RCTs of vitamin D supplementation during pregnancy showed no evidence of an effect on the incidence of eczema (pooled odds ratio [OR] = 0.85; 0.67–1.08, I2 = 6.7%, n = 2074). Three RCTs reported null associations between supplementation in pregnancy/infancy and food allergy. From six cohort studies, increasing cord blood vitamin D levels were associated with reduced prevalence of eczema at/close to age one (OR per 10 nmol/L increase = 0.89; 0.84–0.94, I2 = 0%, 2025 participants). We found no evidence of an association between maternal antenatal or infant vitamin D level or dietary intake and the development of food allergy or eczema in offspring. Conclusions We found an association between higher vitamin D levels in cord blood and reduced risk of eczema in cohort studies. Further trials with maternal and infant supplementation are needed to confirm if vitamin D supplementation can effectively prevent eczema or food allergy in childhood. Systematic review registration PROSPERO, No. CRD42013005559.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Outcome Assessmentmentioning

confidence: 99%

See 2 more Smart Citations

Is antenatal or early‐life vitamin D associated with eczema or food allergy in childhood? A systematic review

Zeng

Shen

et al. 2023

Clin Experimental Allergy

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“…A prospective cohort study in Chinese infants, suggested that cord blood 25(OH)D3 at an insufficient level (20 ng/mL ≤ 25(OH)D3 < 30 ng/mL) is more closely associated with predisposition to FA in infants at 6 months than a deficient state (25(OH)D3 < 20 ng/mL) [ 83 ]. Cord blood 25(OH)D3 deficiency appears to have a protective effect on the incidence of FA at this age, while a sufficient 25(OH)D3 level in infant cord blood was an independent risk factor for FA [ 84 ]. The German LINA cohort study confirmed that higher maternal and cord blood levels of 25(OH)D3 are associated with a risk of FA or sensitization to food allergens in children in the first 2 years of life [ 85 ].…”

Section: Vitamin D Supplementation In Pregnancy; Nutritional Benefits...mentioning

confidence: 99%

Vitamin D and Omega-3 (Fatty Acid) Supplementation in Pregnancy for the Primary Prevention of Food Allergy in Children-Literature Review

et al. 2023

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During the last decades the prevalence of food allergy (FA), an adverse immune response to a specific food antigen, has risen, with negative effects on the quality of life (QoL) of many children and their families. The pathogenesis of FA is complex, involving both genetic and environmental factors. SPINK5, STAT6, HLA and FOXP3 are some of the genes that are reported to be implicated in FA development. Regarding environmental factors, particular interest has been focused on modification of the dietary habits of pregnant women for the primary prevention of FA. Specifically, Vitamin D and omega-3 (Ω-3) fatty acid supplementation during pregnancy may influence the development of FA in the offspring. Vitamin D is a hormone with various actions, including mediation of the immune system, reducing the production of inflammatory cytokines and promoting tolerance. Vitamin D deficiency in pregnancy suppresses T-regulatory cells in the fetus, and Vitamin D supplementation might protect against FA development. Dietary Ω-3 fatty acids are found mainly in fish and vegetable oils. They are beneficial for human health, playing a role in the immune system as anti-inflammatory agents, and providing cell membrane stabilization with inhibition of antigen presentation. It is documented that maternal supplementation with Ω-3 during pregnancy may protect from allergic sensitization in the children. The aim of this literature review was to explore the potential preventive role of maternal supplementation during pregnancy with Vitamin D and Ω-3 in the development of FA in the offspring. With the prevalence of FA rising, all the possible protective mechanisms and measures for FA prevention need to be explored, starting with those that can be modified.

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Understanding risk factors for developing food allergy: What do epidemiological data tell us?

Warren,

Liu,

Assaf

et al. 2024

Encyclopedia of Food Allergy

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Cord blood 25(OH)D3, cord blood total immunoglobulin E levels, and food allergies in infancy: A birth cohort study in Chongqing, China

Cited by 5 publications

References 45 publications

Is antenatal or early‐life vitamin D associated with eczema or food allergy in childhood? A systematic review

Is antenatal or early‐life vitamin D associated with eczema or food allergy in childhood? A systematic review

Vitamin D and Omega-3 (Fatty Acid) Supplementation in Pregnancy for the Primary Prevention of Food Allergy in Children-Literature Review

Understanding risk factors for developing food allergy: What do epidemiological data tell us?

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