Cord blood fatty acid composition in infants and in their mothers during the third trimester

Friedman, Zvi; Danon, Abraham; Lamberth, Edwin L.; Mann, William J.

doi:10.1016/s0022-3476(78)80450-8

Cited by 85 publications

(46 citation statements)

References 24 publications

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“…The concept of a preferential and selective transfer of LC-PUFA emerged from observations that maternal plasma lipids at birth contained higher percentage levels of the precursors ALA and LA than cord blood lipids of their infants, but percentage values for LC-PUFA were clearly and significantly higher in infants than in their mothers (3,4). In contrast, some studies performed in human perfused placentas showed a higher rate of placental transfer for LA that for AA (10, 13).…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies have reported that, in contrast to essential fatty acids (EFA), LC-PUFA percentages in the lipids of cord plasma are higher than in maternal plasma at the time of birth (3,4). Since the ability of the fetus and the human placenta to desaturate and elongate fatty acids is limited (5), a preferential materno-fetal transfer of LCPUFA has been suggested.…”

mentioning

confidence: 99%

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In vivo investigation of the placental transfer of 13C-labeled fatty acids in humans

Larqué¹,

Demmelmair²,

Berger

et al. 2003

Journal of Lipid Research

114

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

In vivo investigation of the placental transfer of 13C-labeled fatty acids in humans

Larqué¹,

Demmelmair²,

Berger

et al. 2003

Journal of Lipid Research

114

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show abstract

“…Results from pre-and postnatal analysis of fetal plasma PL showed that 22:6n 7 3 levels increase during pregnancy (Friedman et al, 1978;Houwelingen et al, 1996). Gestational age at birth, therefore, largely determines the neonate's 22:6n 7 3 status.…”

Section: Discussionmentioning

confidence: 99%

Maternal and neonatal essential fatty acid status in phospholipids: an international comparative study

et al. 1997

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Objective: To investigate whether the steady decline in the maternal essential fatty acids (EFA) status during pregnancy observed in Dutch pregnant women is a local or general phenomenon. Design: The EFA status was measured during uncomplicated, singleton pregnancy of healthy women from the Netherlands, Hungary, Finland, England and Ecuador. In addition, the EFA status of their neonates were measured at birth. Fatty acid pro®les were analyzed in phospholipids isolated from maternal plasma and from umbilical plasma and cord vessel walls. Results: Considerable differences between these centers were observed in the maternal EFA levels and EFA status indexes. However, the change in the absolute as well as relative amounts of the EFAs followed a similar course in the ®ve populations during pregnancy. The neonatal EFA pro®les re¯ected the differences found in maternal plasma during pregnancy and shortly after delivery. Comparable correlations were found, particularly, between the neonatal and the maternal n 7 3 fatty acids in the participating groups. Conclusions: It seems that the reduction in maternal EFA status during pregnancy is a general phenomenon, and is largely independent of differences in dietary habits and ethnic origin. Since the lowest values for certain maternal EFAs in a given country were signi®cantly higher than the highest value of these EFAs throughout pregnancy in other countries, the functional implications of the pregnancy-associated reduction in the maternal EFA status for the fetal and neonatal development is not obvious and needs to be further elucidated.

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“…LC-PUFA occur in high concentrations in the central nervous system (Elliot & Knight, 1972), and the brain content of LC-PUFA-arachidonic acid (20:4 (n-6), AA) and docosahexaenoic acid (22:6(n-3), DHA)-increases progressively during brain organogenesis (Crawford et al, 1976). Although a maternal-fetal gradient in most polyunsaturated fatty acids (PUFA) has been reported (Friedman et al, 1978;Al et al, 1990Al et al, , 1995Otto et al, 1997;Min et al, 2001), the percentage of ALA is almost undetectable in fetal plasma and that of LA is nearly half of that in the mother. However, the proportions of AA and DHA are normally higher in the fetus (Cetin et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Relationship between plasma fatty acid profile and antioxidant vitamins during normal pregnancy

et al. 2004

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Objective: To study the changes of plasma fatty acids and lipophilic vitamins during normal pregnancy. Design: Plasma fatty acid profile and the concentration of carotenoids, tocopherols and retinol were measured in healthy women at the first and third trimesters of pregnancy, at delivery, and in cord blood plasma. Results: Maternal plasma cholesterol and triglycerides increased from the first to the third trimester of gestation, while free fatty acids progressively increased from the first trimester through the third trimester to delivery, suggesting an enhanced lipolytic activity. Plasma levels of a-and g-tocopherols, lycopene and b-carotene also progressively increased with gestation, but values in cord blood plasma were lower than in mothers at delivery. Retinol levels declined with gestational time and values in cord blood plasma were even lower. The proportion of total saturated fatty acids increased with gestation, and it further increased in cord blood plasma. Total n-9 fatty acids remained stable throughout pregnancy, and slightly declined in cord blood plasma, the change mainly corresponding to oleic acid. Total n-6 fatty acids declined with gestation and further decreased in cord blood plasma, and a similar trend was found for linoleic acid. However, arachidonic acid declined in women at the third trimester and at delivery as compared to the first trimester, but was enhanced in cord blood plasma. The proportion of total n-3 fatty acids remained stable throughout pregnancy at the expense of decreased a-linolenic acid at delivery but enhanced eicosapentaenoic acid, with small changes in docosahexaenoic acid. The proportion of these n-3 fatty acids was similar in cord blood plasma and maternal plasma at delivery. Conclusions: Owing to the different placental transfer mechanisms and fetal capability to metabolize some of the transferred fatty acids and lipophilic vitamins, the fetus preserves the essential compounds to assure their appropriate availability to sustain its normal development and to protect itself from the oxidative stress of extrauterine life.

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Cord blood fatty acid composition in infants and in their mothers during the third trimester

Cited by 85 publications

References 24 publications

In vivo investigation of the placental transfer of 13C-labeled fatty acids in humans

In vivo investigation of the placental transfer of 13C-labeled fatty acids in humans

Maternal and neonatal essential fatty acid status in phospholipids: an international comparative study

Relationship between plasma fatty acid profile and antioxidant vitamins during normal pregnancy

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