Cord Blood IgE against Milk and Egg Antigens

Abstract

The aim of the present study was to reevaluate the prenatal production of specific IgE for eggs and milk and, in those cases, to determine whether there is a relation to the amount of maternal egg and milk intake. Total and specific IgEs from 160 cord blood samples were determined by immunoassays using a paramagnetic particle solid phase and an enzyme-mediated chemiluminescent reaction for signal detection. The levels of cord blood IgE for total, egg, and milk were 0.63 ± (SD) 1.10 IU/ml, 0.020 ± 0.055, and 0.036 ± 0.053 IU/ml, respectively. IgE levels specific to egg and milk over 0.03 IU/ ml were observed in 33 and 70 out of 160 cases, respectively. To address whether the maternal intake of eggs and milk affects the level of cord blood IgEs, all mothers except 9 were interviewed, and the amount of eggs and milk taken during pregnancy was recorded. No correlation was seen between egg and milk intakes and cord blood IgE levels. Our data demonstrate a high incidence of the prenatal production of specific IgE for eggs and milk which is independent of maternal egg and milk intakes.

Relationship between Cord Blood Level of IgE Specific for <i>Dermatophagoides pteronyssinus</i> and Allergic Manifestations in Infancy

“…However, chemiluminescence methods (including the Lumiward system) make it possible to detect very low levels of IgE and have revealed the existence of food allergen-specific IgE antibodies in cord blood [7,8,12]. In the present study, we were able to detect cord blood Dp-IgE by using the Lumiward system.…”

“…The intra-assay and interassay coefficients of variation of the Lumiward system were ! 8.0% [8]. Maternal atopy was defined on the basis of a total IgE level of 6230 IU/ml (2 SD for Japanese adults !…”

Fetal Programming: Early-life Modulations that Affect Adult Outcomes

“…& Presence of antigens in amniotic fluid and cord blood & Observation of proliferative responses to specific allergens by fetal and infant mononuclear cells & Detection in umbilical cord blood of IgE antibodies to specific allergens present in the maternal environment & Increase in cord blood cytokines preceding the development of asthma [22][23][24][25][26][27][28].…”

Prenatal latex sensitization in patients with spina bifida: a pilot study

“…6 Several reports have demonstrated the associationoftotalIgElevels,allergen-specificIgE,and allergen-specificT-cellmemoryincordbloodandthedevelopmentofatopicdiseaseinchildhood. 5,13 Intrauterine allergen exposure has been documented in cord blood andamnioticfluid,indicatingthepossibilityofintrauterinesensitization.…”