Cord Blood Metabolic Signatures of Birth Weight: A Population-Based Study

Robinson, Oliver; Keski‐Rahkonen, Pekka; Chatzi, Leda; Kogevinas, Manolis; Nawrot, Tim S.; Pizzi, Costanza; Plusquin, Michelle; Richiardi, Lorenzo; Robinot, Nivonirina; Sunyer, Jordi; Vermeulen, Roel; Vrijheid, Martine; Víneis, Paolo; Scalbert, Augustin; Chadeau‐Hyam, Marc

doi:10.1021/acs.jproteome.7b00846

Cited by 47 publications

(76 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, very recently Robinson et al . 50 observed in line with our results a negative association between birth weight, indolelactic acid and PCs in a population based study. The additional effect of PE could be controlled by comparing results with small for gestational age, non-PE newborns.…”

Section: Discussionsupporting

confidence: 93%

A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants

Jääskeläinen

Kärkkäinen

Jokkala

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Preeclampsia (PE) is a complex pregnancy disorder. It is not extensively known how the metabolic alterations of PE women contribute to the metabolism of newborn. We applied liquid chromatography-mass spectrometry (LC-MS) based non-targeted metabolomics to determine whether the metabolic profile of plasma from umbilical cord differs between infants born to PE and non-PE pregnancies in the FINNPEC study. Cord plasma was available from 42 newborns born from PE and 53 from non-PE pregnancies. 133 molecular features differed between PE and non-PE newborns after correction for multiple testing. Decreased levels of 4-pyridoxic acid were observed in the cord plasma samples of PE newborns when compared to non-PE newborns. Compounds representing following areas of metabolism were increased in the cord plasma of PE newborns: urea and creatine metabolism; carnitine biosynthesis and acylcarnitines; putrescine metabolites; tryptophan metabolism and phosphatidylcholines. To our knowledge, this study is the first one to apply LC-MS based metabolomics in cord plasma of PE newborns. We demonstrate that this strategy provides a global picture of the widespread metabolic alterations associated with PE and particularly the elevated levels of carnitine precursors and trimethylated compounds appear to be associated with PE at birth.

show abstract

Section: Discussionsupporting

confidence: 93%

A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants

Jääskeläinen

Kärkkäinen

Jokkala

et al. 2018

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Also, we identified two sphingolipids (SM C16:1 and SM C18:1) to be both higher in females and positively associated with BMI z-score, possibly reflecting differences in body fat composition and physical development between boys and girls. Also, two of the lysophosphatidylcholines (lysoPC a C16:1, lysoPC a C18:1) associated with BMI z-score in this study have recently been shown to be correlated to infant birth weight [ 89 ]. Moreover, out of the 41 serum metabolites found to be associated with BMI z-score in our HELIX children cohort, 14 metabolites (including kynurenine, glutamate, lysoPC a C18:1, lysoPC a C18:2) have also previously been reported in the EPIC study in an adult population, where the Absolute IDQ p180 kit was also used [ 90 ], demonstrating that many serum metabolic associations with BMI observed in adulthood can also be found in childhood.…”

Section: Discussionmentioning

confidence: 99%

Determinants of the urinary and serum metabolome in children from six European populations

Lau

Siskos

Maitre

et al. 2018

BMC Med

Self Cite

117

140

View full text Add to dashboard Cite

BackgroundEnvironment and diet in early life can affect development and health throughout the life course. Metabolic phenotyping of urine and serum represents a complementary systems-wide approach to elucidate environment–health interactions. However, large-scale metabolome studies in children combining analyses of these biological fluids are lacking. Here, we sought to characterise the major determinants of the child metabolome and to define metabolite associations with age, sex, BMI and dietary habits in European children, by exploiting a unique biobank established as part of the Human Early-Life Exposome project (http://www.projecthelix.eu).MethodsMetabolic phenotypes of matched urine and serum samples from 1192 children (aged 6–11) recruited from birth cohorts in six European countries were measured using high-throughput 1H nuclear magnetic resonance (NMR) spectroscopy and a targeted LC-MS/MS metabolomic assay (Biocrates AbsoluteIDQ p180 kit).ResultsWe identified both urinary and serum creatinine to be positively associated with age. Metabolic associations to BMI z-score included a novel association with urinary 4-deoxyerythreonic acid in addition to valine, serum carnitine, short-chain acylcarnitines (C3, C5), glutamate, BCAAs, lysophosphatidylcholines (lysoPC a C14:0, lysoPC a C16:1, lysoPC a C18:1, lysoPC a C18:2) and sphingolipids (SM C16:0, SM C16:1, SM C18:1). Dietary-metabolite associations included urinary creatine and serum phosphatidylcholines (4) with meat intake, serum phosphatidylcholines (12) with fish, urinary hippurate with vegetables, and urinary proline betaine and hippurate with fruit intake. Population-specific variance (age, sex, BMI, ethnicity, dietary and country of origin) was better captured in the serum than in the urine profile; these factors explained a median of 9.0% variance amongst serum metabolites versus a median of 5.1% amongst urinary metabolites. Metabolic pathway correlations were identified, and concentrations of corresponding metabolites were significantly correlated (r > 0.18) between urine and serum.ConclusionsWe have established a pan-European reference metabolome for urine and serum of healthy children and gathered critical resources not previously available for future investigations into the influence of the metabolome on child health. The six European cohort populations studied share common metabolic associations with age, sex, BMI z-score and main dietary habits. Furthermore, we have identified a novel metabolic association between threonine catabolism and BMI of children.Electronic supplementary materialThe online version of this article (10.1186/s12916-018-1190-8) contains supplementary material, which is available to authorized users.

show abstract

“…Sample extracts were analysed by LC-MS using a 1290 Binary LC system coupled with a 6550 quadrupole time-of-flight (QTOF) mass spectrometer equipped with a jet steam electrospray ionization source (Agilent Technologies, Santa Clara, CA, USA), as previously described [ 35 ]. In short, samples were ordered randomly in the batch.…”

Section: Methodsmentioning

confidence: 99%

Metabolic Signatures of 10 Processed and Non-processed Meat Products after In Vitro Digestion

et al. 2020

Self Cite

View full text Add to dashboard Cite

The intake of processed meat has been associated with several adverse health outcomes such as type II diabetes and cancer; however, the mechanisms are not fully understood. A better knowledge of the metabolite profiles of different processed and non-processed meat products from this heterogeneous food group could help in elucidating the mechanisms associated with these health effects. Thirty-three different commercial samples of ten processed and non-processed meat products were digested in triplicate with a standardized static in vitro digestion method in order to mimic profiles of small molecules formed in the gut upon digestion. A metabolomics approach based on high-resolution mass spectrometry was used to identify metabolite profiles specific to the various meat products. Processed meat products showed metabolite profiles clearly distinct from those of non-processed meat. Several discriminant features related to either specific ingredients or processing methods were identified. Those were, in particular, syringol compounds deposited in meat during smoking, biogenic amines formed during meat fermentation and piperine and related compounds characteristic of pepper used as an ingredient. These metabolites, characteristic of specific processed meat products, might be used as potential biomarkers of intake for these foods. They may also help in understanding the mechanisms linking processed meat intake and adverse health outcomes such as cancer.

show abstract

Cord Blood Metabolic Signatures of Birth Weight: A Population-Based Study

Cited by 47 publications

References 64 publications

A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants

A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants

Determinants of the urinary and serum metabolome in children from six European populations

Metabolic Signatures of 10 Processed and Non-processed Meat Products after In Vitro Digestion

Contact Info

Product

Resources

About