Cord blood telomere length in Latino infants: relation with maternal education and infant sex

Wojcicki, Janet M.; Olveda, Rebecca; Heyman, Melvin B.; Elwan, Deena; Lin, Jue; Blackburn, Elizabeth H.; Epel, Elissa S.

doi:10.1038/jp.2015.178

Cited by 61 publications

(65 citation statements)

References 37 publications

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“…Researchers also have indicated that there were no difference between the RTL of preterm neonates and full-term newborns35. In addition, several studies observed that higher birth weight was associated with longer RTL3637, but which were inconsistent with our findings. Possible reason is that intra-uterine variables that affect newborn RTL are extremely complex, maternal psychosocial stress38, maternal estriol concentrations39, maternal Folate Concentrations40 and undetected factors might play an important role in affecting newborn RTL and disturbed the correlation between birth weight and RTL.…”

Section: Discussioncontrasting

confidence: 88%

The known genetic loci for telomere length may be involved in the modification of telomeres length after birth

Weng

et al. 2016

Sci Rep

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Telomere length varies considerably among individuals. It is highly heritable and decreases with ageing or ageing related diseases. Recently, genome-wide association studies (GWAS) have identified several genetic loci associated with telomere length in adults. However, it is unclear whether these loci represent the genetic basis of telomere length or determine the individual susceptibility to shortening during growth process. Using DNA extracted from peripheral and cord blood of 444 mother-newborn pairs from a Chinese population, we measured relative telomere length (RTL) and genotyped eight known telomere length related variants that were initially identified in populations of European descent. We observed the T allele of rs10936599 and the T allele of rs2736100 were norminally associated with shorter RTL (P = 0.041 and 0.046, respectively) in maternal samples. Furthermore, the Weighted genetic score (WGS) of eight variants was significantly associated with RTL in maternal samples (R2 = 0.012, P = 0.025). However, we didn’t detect any significant associations for any individual variant or the combined WGS with RTL in newborns. These findings didn’t support the hypothesis that telomere length related loci may affect telomere length at birth, and we suggested that these loci may play a role in telomere length modification during life course.

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Section: Discussioncontrasting

confidence: 88%

The known genetic loci for telomere length may be involved in the modification of telomeres length after birth

Weng

et al. 2016

Sci Rep

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“…Fourth, we did not examine maternal socio‐demographic factors such as educational level, residential area, and occupation. It was recently reported that maternal education levels (Wojcicki et al, ) and residential traffic exposure (Bijnens et al, ) were associated with telomere lengths at birth. These factors may have been significant confounding factors affecting the relationship between maternal vitamin D concentrations and newborn telomere lengths.…”

Section: Discussionmentioning

confidence: 99%

“…Fourth, we did not examine maternal socio-demographic factors such as educational level, residential area, and occupation. It was recently reported that maternal education levels (Wojcicki et al, 2016) and residential traffic exposure (Bijnens et al, 2015) were associated with telomere lengths at birth.…”

Section: Discussionmentioning

confidence: 99%

Higher maternal vitamin D concentrations are associated with longer leukocyte telomeres in newborns

Kim

Lee

et al. 2017

Maternal & Child Nutrition

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Gestational vitamin D insufficiency is related with increased risks of various diseases and poor health outcomes later in life. Telomere length at birth or early in life is known to be a predictor of individual health. Both vitamin D and telomere length are related with various health conditions, and vitamin D concentrations are associated with leukocyte telomere lengths in women.We investigated the association between maternal vitamin D concentrations and newborn leukocyte telomere lengths. This cross-sectional study included 106 healthy pregnant women without adverse obstetric outcomes and their offspring. We examined the maternal age, weight before pregnancy, health behaviours, and nutritional intakes, along with each newborn's sex and birthweight, and we measured maternal height, telomere length, total white blood cell count, and glycosylated haemoglobin as covariates. Pearson's correlation coefficients were calculated to evaluate the relationship between the baseline variables and newborn leukocyte telomere lengths. To confirm that there was an independent association between newborn leukocyte telomere lengths and maternal vitamin D concentrations, we performed a stepwise multiple linear regression analysis. Newborn leukocyte telomere lengths correlated positively with maternal leukocyte telomere lengths (r = .76, p < .01), maternal 25-hydroxyvitamin D concentrations (r = .72, p < .01), maternal energy intakes (r = .22, p = .03), and newborn body weights (r = .51, p < .01). In the multivariate model, newborn leukocyte telomere lengths were associated with maternal vitamin D concentrations (β = .33, p < .01). These findings suggest that the maternal vitamin D concentration during pregnancy may be a significant determinant of the offspring's telomere length.

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“…A recently published study involved analysis of cord blood telomere length of 54 infants. Female sex was associated with longer telomere length by ~350 bp leading to the conclusion that male infants have a shorter telomere length at birth, but whether this can predict any worse outcome in males than in females is not yet clear and more studies are required to figure out this association (47). Different body organs of male and female fetuses may display distinct antioxidant pathways.…”

Section: Methodsmentioning

confidence: 99%

Effect of Fetal Sex on Maternal and Obstetric Outcomes

2017

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Fetal sex plays an important role in modifying the course and complications related to pregnancy and may also have an impact on maternal health and well-being both during and after pregnancy. The goal of this article is to review and summarize the findings from published research on physiologic and pathologic changes that may be affected by fetal sex and the effect of these changes on the maternal and obstetrical outcomes. This will help create awareness that fetal sex is not just a random chance event but an interactive process between the mother, the placenta, and the fetus. The reported effects of male sex on the course of pregnancy and delivery include higher incidence of preterm labor in singletons and twins, failure of progression in labor, true umbilical cord knots, cord prolapse, nuchal cord, higher cesarean section rate, higher heart rate variability with increased frequency, and duration of decelerations without acidemia and increased risk of gestational diabetes mellitus through the poor beta cells function. Similarly, female fetal sex has been reported to modify pregnancy and delivery outcomes including altered fetal cardiac hemodynamics, increased hypertensive diseases of pregnancy, higher vulnerability of developing type 2 DM after pregnancy possibly because of influences on increased maternal insulin resistance. Placental function is also influenced by fetal sex. Vitamin D metabolism in the placenta varies by fetal sex; and the placenta of a female fetus is more responsive to the relaxing action of magnesium sulfate. Male and female feto-placental units also vary in their responses to environmental toxin exposure. The association of fetal sex with stillbirths is controversial with many studies reporting higher risk of stillbirth in male fetuses; although some smaller and limited studies have reported more stillbirths with female fetus pregnancies. Maternal status such as BMI may in turn also affect the fetus and the placenta in a sex-specific manner. There is probably a sex-specific maternal–placental–fetal interaction that has significant biological implications of which the mechanisms may be genetic, epigenetic, or hormonal. Determination of fetal sex may therefore be an important consideration in management of pregnancy and childbirth.

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Cord blood telomere length in Latino infants: relation with maternal education and infant sex

Cited by 61 publications

References 37 publications

The known genetic loci for telomere length may be involved in the modification of telomeres length after birth

The known genetic loci for telomere length may be involved in the modification of telomeres length after birth

Higher maternal vitamin D concentrations are associated with longer leukocyte telomeres in newborns

Effect of Fetal Sex on Maternal and Obstetric Outcomes

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