Cord blood telomere length, telomerase activity and inflammatory markers in pregnancies in women with diabetes or gestational diabetes

Cross, Jennifer; Temple, Rosemary; Hughes, Jackie C.; Dozio, Nicoletta; Brennan, Carmel; Stanley, Katherine; Murphy, H; Fowler, Duncan; Hughes, David A.; Sampson, Mike

doi:10.1111/j.1464-5491.2010.03099.x

Cited by 45 publications

(36 citation statements)

References 23 publications

(30 reference statements)

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“…Still, whether these or other factors might be the determining ones of the modifications of the telomere length in LGA babies remains to be explored. In agreement with the hypothesis of the in utero reprogramming toward senescence, previous evidence showed higher cord blood telomerase activity in Type 1 and gestational diabetes34.…”

Section: Discussionsupporting

confidence: 90%

Telomere length in the two extremes of abnormal fetal growth and the programming effect of maternal arterial hypertension

Tellechea

Gianotti

Alvariñas³

et al. 2015

Sci Rep

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We tested the hypothesis that leukocyte telomere length (LTL) is associated with birth weight in both extremes of abnormal fetal growth: small (SGA) and large for gestational age newborns (LGA). Clinical and laboratory variables of the mothers and the neonates were explored; 45 newborns with appropriate weight for gestational age (AGA), 12 SGA and 12 LGA were included. Whether the differences might be explained by variation in OBFC1 (rs9419958) and CTC1 (rs3027234) genes associated with LTL was determined. A significant association between birth weight and LTL was observed; LTL was significantly shorter in LGA newborns (1.01 ± 0.12) compared with SGA (1.73 ± 0.19) p < 0.005, mean ± SE. Maternal (Spearman R = −0.6, p = 0.03) and neonatal LTL (R = −0.25, p = 0.03) were significantly and inversely correlated with maternal history of arterial hypertension in previous gestations. Neonatal LTL was not significantly associated with either rs9419950 or rs3027234, suggesting that the association between neonatal LTL and birth weight is not influenced by genetic variation in genes that modify the interindividual LTL. In conclusion, telomere biology seems to be modulated by abnormal fetal growth; modifications in telomere length might be programmed by an adverse environment in utero.

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Section: Discussionsupporting

confidence: 90%

Telomere length in the two extremes of abnormal fetal growth and the programming effect of maternal arterial hypertension

Tellechea

Gianotti

Alvariñas³

et al. 2015

Sci Rep

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“…This result indicated that Sitagliptin might protect pancreatic β-cells from damage by elongating the length of its telomere (Ma et al, 2014). Moreover, a previous study performed on cord blood samples from pregnant women with pregestational T1DM, T2DM and gestational diabetes found significant differences between groups telomerase activity (it was high in cord blood from Type 1 and gestational diabetes pregnancies, but not in Type 2 diabetes) (Cross et al, 2010).…”

Section: Discussionmentioning

confidence: 94%

Association Of Telomerase Activity With The Prognosis Of Diabetes Mellitus In Saudi Population

Kumosani¹,

Iyer²,

Al‐Ghafari³

et al. 2017

JEBAS

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Telomeres are important for chromosome stability and they are replenished by telomerase enzyme. Impaired telomerase activity has a strong association with ageing and diabetes. Research data have shown that telomerase activity plays a vital role in pathogenesis of type I and type II diabetes by influencing pancreatic cell regeneration. This study was aimed to assess telomerase activity in three diabetic groups (type I, type II and gestational diabetes mellitus (GDM)) and compare it with a population with normal blood glucose levels to establish a correlation between reduced telomerase activity and prognosis of diabetes in the Saudi population. This study was conducted on 200 Saudi diabetic and non-diabetic participants (20-60 years). Peripheral mononuclear cells (PMNCs) were extracted from the blood samples and the activity of telomerase in the PMNCs was detected by the TRAP-ELISA assay. Results of study revealed that there was no telomerase activity in control healthy group, moderate activity in type I, some activity in GDM, and significantly high activity in type II group. This might indicate that telomerase activity has a strong correlation to the prognosis of type II diabetes. However, the molecular mechanism still needs to be investigated. .

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“…Little is known about DNA damage in pregnancy, especially in pregnancy complicated by pregestational (T1DM or T2DM) or gestational diabetes mellitus (GDM) [7, 37–39, 41, 49]. …”

Section: Hyperglycemia Dna Damage and Pregnancy: Results Of Expementioning

confidence: 99%

“…No difference was found in cord blood telomere length in pregnancies of women with diabetes compared with control subjects, but higher telomerase activity was observed in Type 1 and GDM groups. The upregulation of telomerase may be a compensatory response to in utero oxidatively generated DNA and telomere damage [41]. …”

Section: Hyperglycemia Dna Damage and Pregnancy: Results Of Expementioning

confidence: 99%

DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment

Moreli

Santos

Rocha

et al. 2014

BioMed Research International

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The increased production of reactive oxygen species (ROS) plays a key role in pathogenesis of diabetic complications. ROS are generated by exogenous and endogenous factors such as during hyperglycemia. When ROS production exceeds the detoxification and scavenging capacity of the cell, oxidative stress ensues. Oxidative stress induces DNA damage and when DNA damage exceeds the cellular capacity to repair it, the accumulation of errors can overwhelm the cell resulting in cell death or fixation of genome mutations that can be transmitted to future cell generations. These mutations can lead to and/or play a role in cancer development. This review aims at (i) understanding the types and consequences of DNA damage during hyperglycemic pregnancy; (ii) identifying the biological role of DNA repair during pregnancy, and (iii) proposing clinical interventions to maintain genome integrity. While hyperglycemia can damage the maternal genetic material, the impact of hyperglycemia on fetal cells is still unclear. DNA repair mechanisms may be important to prevent the deleterious effects of hyperglycemia both in mother and in fetus DNA and, as such, prevent the development of diseases in adulthood. Hence, in clinical practice, maternal glycemic control may represent an important point of intervention to prevent the deleterious effects of maternal hyperglycemia to DNA.

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Cord blood telomere length, telomerase activity and inflammatory markers in pregnancies in women with diabetes or gestational diabetes

Cited by 45 publications

References 23 publications

Telomere length in the two extremes of abnormal fetal growth and the programming effect of maternal arterial hypertension

Telomere length in the two extremes of abnormal fetal growth and the programming effect of maternal arterial hypertension

Association Of Telomerase Activity With The Prognosis Of Diabetes Mellitus In Saudi Population

DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment

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